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Leistungsverzeichnis

Publikationen

Nachfolgend sind ausgewählte Publikationen seit 2008 aufgelistet, die in Zusammenarbeit mit verschiedenen Kliniken entstanden sind:

2016

Krautkrämer E, Nusshag C, Baumann A, Schäfer J, Hofmann J, Schnitzler P, Klempa B, Witkowski PT, Krüger DH, Zeier M. Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi. BMC Infect Dis. 2016 Nov 14;16(1):675. PubMed PMID: 27842513.

Schulz M, Beha D, Plehm K, Zöllner C, Hofmann J, Schott E. High prevalence of anti-hepatitis E virus antibodies in outpatients with chronic liver disease in a university medical center in Germany. Eur J Gastroenterol Hepatol. 2016 Dec;28(12):1431-1436. PubMed PMID: 27552296.

Brakemeier S, Taxeidi SI, Dürr M, Hofmann J, Schmidt D, Bachmann F, Gaedeke J, Budde K. Clinical outcome of norovirus infection in renal transplant patients. Clin Transplant. 2016 Oct;30(10):1283-1293. PubMed PMID:27447127.

Hillebrandt KH, Arsenic R, Hofmann J, Eurich D, Gül S, Strücker B, Sauer IM, Pratschke J, Stockmann M, Raschzok N. Acute Graft Dysfunction 17 Years After Liver Transplant: A Challenging Clinical and Histologic Manifestation of Hepatitis E. Exp Clin Transplant. 2016 Jun 15.PubMed PMID: 27310664.

Feiterna-Sperling C, Königs C, Notheis G, Buchholz B, Krüger R, Weizsäcker K, Eberle J, Hanhoff N, Gärtner B, Heider H, Krüger DH, Hofmann J. High seroprevalence of antibodies against Kaposi's sarcoma-associated herpesvirus (KSHV) among HIV-1-infected children and adolescents in a non-endemic population. Med Microbiol Immunol. 2016 Oct;205(5):425-34. PubMed PMID: 27240652.

Johne R, Trojnar E, Filter M, Hofmann J. Thermal Stability of Hepatitis E Virus as Estimated by a Cell Culture Method. Appl Environ Microbiol. 2016 Jun 30;82(14):4225-31. PubMed PMID: 27208095.

Klein F, Neuhaus R, Eurich D, Hofmann J, Bayraktar S, Pratschke J, Bahra M. Two-Year Follow-Up Analysis of Telaprevir-Based Antiviral Triple Therapy for HCV Recurrence in Genotype 1 Infected Liver Graft Recipients as a First Step towards Modern HCV Therapy. Hepat Res Treat. 2016;2016:8325467. PubMed PMID: 27195149.

Otto C, Hofmann J, Ruprecht K. Antibody producing B lineage cells invade the central nervous system predominantly at the time of and triggered by acute Epstein-Barr virus infection: A hypothesis on the origin of intrathecal immunoglobulin synthesis in multiple sclerosis. Med Hypotheses. 2016 Jun;91:109-13. PubMed PMID: 27142157.

Fischer L, Imrich E, Sampaio KL, Hofmann J, Jahn G, Hamprecht K, Göhring K. Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance. Antiviral Res. 2016 Jul;131:1-8.PubMed PMID: 27058773.

Heinrich A, Haarmann H, Zahradnik S, Frenzel K, Schreiber F, Klassert TE, Heyl KA, Endres AS, Schmidtke M, Hofmann J, Slevogt H. Moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells. FASEB J. 2016 Jun;30(6):2426-34. PubMed PMID: 26979086.

Voigt S, Hofmann J, Edelmann A, Sauerbrei A, Kühl JS. Brincidofovir clearance of acyclovir-resistant herpes simplex virus-1 and adenovirus infection after stem cell transplantation. Transpl Infect Dis. 2016 Oct;18(5):791-794. PubMed PMID: 27482652.

Allers K, Puyskens A, Epple HJ, Schürmann D, Hofmann J, Moos V, Schneider T. The effect of timing of antiretroviral therapy on CD4+ T-cell reconstitution in the intestine of HIV-infected patients. Mucosal Immunol. 2016 Jan;9(1):265-74. PubMed PMID: 26129649.

2015

Haag LM, Hofmann J, Kredel LI, Holzem C, Kühl AA, Taube ET, Schubert S,
Siegmund B, Epple HJ. Herpes Simplex Virus Sepsis in a Young Woman with Crohn's Disease. J Crohns Colitis. 2015 Dec;9(12):1169-73.
PMID: 26351382.

Hofmann J, Grunert HP, Donoso-Mantke O, Zeichhardt H, Kruger DH. Does
proficiency testing improve the quality of hantavirus serodiagnostics?
Experiences with INSTAND EQA schemes. Int J Med Microbiol. 2015
Oct;305(7):607-11.
PMID: 26342877.

Pfuhl C, Oechtering J, Rasche L, Gieß RM, Behrens JR, Wakonig K, Freitag E, Pache FC, Otto C, Hofmann J, Eberspächer B, Bellmann-Strobl J, Paul F, Ruprecht K. Association of serum Epstein-Barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis. J Neuroimmunol. 2015 Aug 15;285:156-60. 
PMID: 26198934.

van Bömmel F, Bartens A, Mysickova A, Hofmann J, Krüger DH, Berg T, Edelmann A. Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors. Hepatology. 2015 Jan;61(1):66-76.
PMID: 25132147.

Sadeghi M, Lahdou I, Ettinger J, Navid MH, Daniel V, Zeier M, Hofmann J, Opelz G, Schnitzler P. Association of low serum TGF-β level in hantavirus infected patients with severe disease. BMC Immunol. 2015 Apr 14;16:19.
PMCID: 4399110.

Kobak L, Raftery MJ, Voigt S, Kühl AA, Kilic E, Kurth A, Witkowski P, Hofmann J, Nitsche A, Schaade L, Krüger DH, Schönrich G. Hantavirus-induced pathogenesis in mice with a humanized immune system. J Gen Virol. 2015 Jun;96(Pt 6):1258-63.
PMID: 25678530.

Klein F, Neuhaus R, Hofmann J, Rudolph B, Neuhaus P, Bahra M. Successful Treatment of Chronic Hepatitis E After an Orthotopic Liver Transplant With Ribavirin Monotherapy. Exp Clin Transplant. 2015 Jun;13(3):283-6.
PMID: 24779678.

2014

Krüger DH, Hofmann J, Krautkrämer E, Zeier M. [A zoonotic viral threat: news about hantavirus disease]. Dtsch Med Wochenschr. 2014 Aug;139(31-32):1576-8.
PMID: 25076309.

Raftery MJ, Lalwani P, Krautkrӓmer E, Peters T, Scharffetter-Kochanek K,
Krüger R, Hofmann J, Seeger K, Krüger DH, Schönrich G. β2 integrin mediates
hantavirus-induced release of neutrophil extracellular traps. J Exp Med. 2014 Jun 30;211(7):1485-97.
PMCID: 4076588.

Ruprecht K, Wunderlich B, Gieß R, Meyer P, Loebel M, Lenz K, Hofmann J, Rosche B, Wengert O, Paul F, Reimer U, Scheibenbogen C. Multiple sclerosis: the elevated antibody response to Epstein-Barr virus primarily targets, but is not confined to, the glycine-alanine repeat of Epstein-Barr nuclear antigen-1. J Neuroimmunol. 2014 Jul 15;272(1-2):56-61.
PMID: 24798244.

Eis-Hübinger AM, Reber U, Edelmann A, Kalus U, Hofmann J. Parvovirus B19 genotype 2 in blood donations. Transfusion. 2014 Jun;54(6):1682-4.
PMID: 24911910.

Johne R, Reetz J, Ulrich RG, Machnowska P, Sachsenröder J, Nickel P, Hofmann J. An ORF1-rearranged hepatitis E virus derived from a chronically infected patient efficiently replicates in cell culture. J Viral Hepat. 2014 Jun;21(6):447-56.
PMID: 24750215.

Hofmann J, Meier M, Enders M, Führer A, Ettinger J, Klempa B, Schmidt S, Ulrich RG, Kruger DH. Hantavirus disease in Germany due to infection with Dobrava-Belgrade virus genotype Kurkino. Clin Microbiol Infect. 2014
Oct;20(10):O648-55.
PMID: 24438436.

Frenzel K, Lehmann J, Krüger DH, Martin-Parras L, Uharek L, Hofmann J.
Combination of immunoglobulins and natural killer cells in the context of CMV and EBV infection. Med Microbiol Immunol. 2014 Apr;203(2):115-23.
PMID: 24337366.

Otto C, Hofmann J, Finke C, Zimmermann M, Ruprecht K. The fraction of varicella zoster virus-specific antibodies among all intrathecally-produced antibodies discriminates between patients with varicella zoster virus reactivation and multiple sclerosis. Fluids Barriers CNS. 2014 Feb 12. PMID: 24517462

2013

Frenzel K, Lehmann J, Krüger DH, Martin-Parras L, Uharek L, Hofmann J. Combination of immunoglobulins and natural killer cells in the context of CMV and EBV infection. Med Microbiol Immunol. 2013 Dec 15. [Epub ahead of print] PMID: 24337366

Wengert O, Rothenfusser-Korber E, Vollrath B, Bohner G, Scheibe F, Otto C, Hofmann J, Angstwurm K, Ruprecht K. Neurosarcoidosis: correlation of cerebrospinal fluid findings with diffuse leptomeningeal gadolinium enhancement on MRI and clinical disease activity. J Neurol Sci. 2013; 15;335(1-2):124-130  PMID: 24071064

Krüger, Detlev H.; Ulrich, Rainer G.; Hofmann, J: Hantaviren als zoonotische Krankheitserreger in Deutschland. Deutsches Ärzteblatt Int 2013

Krüger DH, Ulrich RG, Hofmann J. Organversagen und Hantavirus-Infektion: Ein in Deutschland noch unterschätzter Krankheitserreger. Deutsches Ärzteblatt 2013, Juli

Johne R, Reetz J, Ulrich RG, Machnowska P, Sachsenröder J, Nickel P, Hofmann J. A self-recombinant hepatitis E virus derived from a chronically infected patient efficiently replicates in cell culture. J viral Hepat. June 2013 accepted

Korup S, Rietscher J, Calvignac-Spencer S, Trusch F, Hofmann J, Moens U, Sauer I, Voigt S, Schmuck R, Ehlers B. Identification of a novel human polyomavirus in organs of the gastrointestinal tract. PLoS One. 2013; 8(3):e58021.  PMID: 23516426

Deuschle K, Hofmann J, Otto C, Bellmann-Strobl J, Scherner O, Klumbies K, Schneider E, Broddack J, Paul F, Ruprecht K. Are there Epstein-Barr virus seronegative patients with multiple sclerosis? Mult Scler. 2013 Jan 10. [Epub ahead of print] PMID: 23307904

Scuda N, Madinda NF, Akoua-Koffi C, Adjogoua EV, Wevers D, Hofmann J, Cameron KN, Leendert SAJ, Couacy-Hymann E, Robbins M, Boesch C, Jarvis MA, Moens U, Mugisha L,  Calvignac-Spencer S, Leendertz FH, Ehlers B: Novel Polyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for the Existence of Multiple. PLoS Path. 2013; 9(6):e 1003429. PMID: 23818846

Edelmann A, Eichenlaub U, Lepek S, Krüger DH, Hofmann J. Performance of the MagNA Pure 96 System for Cytomegalovirus Nucleic Acid Amplification Testing in Clinical Samples. J Clin Microbiol. 2013; 51(5):1600-1. PMID: 23467597

2012

Prüss H, Finke C, Höltje M, Hofmann J, Klingbeil C, Probst C, Borowski K, Ahnert-Hilger G, Harms L, Schwab JM, Ploner CJ, Komorowski L, Stoecker W, Dalmau J, Wandinger KP.  N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis. Ann Neurol. 2012; 72(6):902-11. PMID: 23280840

Führer A, Bolz M, Hofmann J. Hantavirusinfektion durch Dobrava-Belgrad-Virus bei einer schwangeren Patientin im 3. Trimenon.  Dtsch Med Wochenschr 2012, 137: 2369–2372 PMID: 23132155

Liman P, Babel N, Schachtner T, Unterwalder N, Konig J, Hofmann J, Reinke P, Nickel P: Mannose-binding lectin deficiency is not associated with increased risk for polyomavirus nephropathy. Transpl Immunol 2012; 26(2-3): 123-127

Hofmann J, Führer A, Bolz M, Waldschläger-Terpe J, Meier M, Lüdders D, Enders M, Oltmann A, Meisel H, Krüger DH. Hantavirus infections by Puumala or Dobrava-Belgrade virus in pregnant women. J Clin Virol. 2012; 55(3): 266-9

Sarıgüzel N*,  Hofmann J*, Canpolat AT, Türk A, Ettinger J, Atmaca D, Akyar I, Yücel S, Arıkan E, Uyar Y, Çağlayık DY, Kocagöz AS, Kaya A, Kruger DH. Dobrava hantavirus infection with panhypopituitarism, Istanbul-Turkey.  Emerg Infect Dis 2012; 18(7): 1180-3 (* equally contributed) PMID: 22709722

Ettinger J., Hofmann J., Enders M., Tewald F., Oehme R.M., Rosenfeld U.M., Ali H.S., Schlegel M., Essbauer S., Osterberg A., Jacob J., Reil D., Klempa B., Ulrich R.G., Kruger D.H. (2012): Multiple synchronous outbreaks of puumala virus, Germany, 2010. Emerg Infect Dis. 2012 Sep;18(9):1461-4. PMID: 22932394 

Eckerle I, Jakob E, Hofmann J, Schmidt-Bacher A, Ettinger J, Schnitzler P. Atypical severe Puumala hantavirus infection with virus sequence analysis from the patient and regional reservoir host. Zoonoses and Public Health  2012; 59(s2): 110–5 PMID: 22958255

Steiner T, Ettinger J, Peng Z, Hofmann J, Hartmann M, Burkhardt M,  Schnitzler P. Hyperintense lesion in the corpus callosum associated with Puumala hantavirus infection. J Neurol 2012; 259(8):  PMID: 22349863

Sauerbrei A, Schäfler A, Hofmann J, Schacke M, Gruhn P, Wutzler P. Evaluation of Three Commercial Varicella-Zoster Virus IgG Enzyme-Linked Immunosorbent Assays in Comparison to the Fluorescent-Antibody-to-Membrane-Antigen Test. Clin. Vaccine Immunol. 2012, 19(8):1261. PMID: 22718131

Dremsek P, Wenzel JJ, Johne R, Ziller M, Hofmann J, Groschup MH, Werdermann S, Mohn U, Dorn S, Motz M, Mertens M, Jilg W, Ulrich RG. Seroprevalence study in forestry workers from eastern Germany using novel genotype 3- and rat hepatitis E virus-specific immunoglobulin G ELISAs. Med Microbiol Immunol 2012; 201:189–200 PMID: 22179131

Frenzel K., Ganepola S., Michel D., Thiel E., Krüger DH., Uharek L. und Hofmann J. (2012): Antiviral function and efficacy of polyvalent immunoglobulin products against CMV isolates in different human cell lines; Med Microbiol Immunol 2012; Epub ahead. PMID: 22297735

Loyen M, Helmchen U, Hofmann J, Krüger DH, Clasen W. Von Mäusen auf Menschen – Erkenntnisse aus der Hantavirus-Epidemie 2010. Dtsch Med Wochenschr 2012, 1370: 309–313 PMID: 22318843

Rosche B, Laurent S, Conradi S, Hofmann J, Ruprecht K, Harms L. Measles IgG antibody index correlates with T2 lesion load on MRI in patients with early multiple sclerosis. PLoS One 2012, 7(1): e28094 PMID: 22276094 PMCID: PMC3261854

2011

Schlosser B., Stein A., Neuhaus R., Pahl S., Ramez B., Kruger DH., Berg T., Hofmann J. (2011): Liver transplant from a donor with occult HEV infection induced chronic hepatitis and cirrhosis in the recipient; J Hepatol 2011; epub ahead. PMID: 21798217

Trusch F., Klein M., Finsterbusch T., Kühn J., Hofmann J.*, Ehlers B.* (2011): Seroprevalence of the human polyomavirus 9 (1 HPyV9) and cross-reactivity to the African green monkey-derived lymphotropic polyomavirus (LPyV); J Gen Virol 2011 (* equally contributed). PMID: 22218677

Allers K., Hutter G., Hofmann J., Loddenkemper C., Rieger K., Thiel E., Schneider T. (2011): Evidence for the cure of HIV infection by CCR5{Delta}32/{Delta}32 stem cell transplantation; Blood 2011; 117: 2791-2799. PMID: 21148083

Engler JB., Undeutsch R., Kloke L., Rosenberger S., Backhaus M., Schneider U., Egerer K., Dragun D., Hofmann J., Huscher D., Burmester G-R., Humrich JY., Enghard P., Riemekasten G. (2011): Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic lupus erythematosus; Ann Rheum Dis 2011. 70(12):2176-83. PMID: 21926188

Kampmann SE., Schindele B., Apelt L., Bührer C., Garten L., Weizsaecker K., Krüger DH., Ehlers B., Hofmann J. (2011): Pyrosequencing allows the detection of emergent ganciclovir resistance-mutations after HCMV infection; Med Microbiol Immunol 2011; 200: 109-113. PMID: 21165648

Otto C., Oltmann A., Stein A., Frenzel K., Schroeter J., Habbel P., Gartner B., Hofmann J.*, Ruprecht K.* (2011): Intrathecal EBV antibodies are part of the polyspecific immune response in multiple sclerosis; Neurology 2011;76(15):1316-1321 (* equally contributed). PMID: 21482946