{"id":16094,"date":"2024-06-13T14:57:24","date_gmt":"2024-06-13T12:57:24","guid":{"rendered":"https:\/\/www.laborberlin.com\/fachbereiche\/autoimmune-diagnostics\/"},"modified":"2025-11-05T09:44:17","modified_gmt":"2025-11-05T08:44:17","slug":"autoimmune-diagnostics","status":"publish","type":"departments","link":"https:\/\/www.laborberlin.com\/en\/departments\/autoimmune-diagnostics\/","title":{"rendered":"Autoimmune Diagnostics"},"content":{"rendered":"<div class=\"Module Banner Banner--small  Background Background--autoimmundiagnostikFullTone Color Color--white\" >\n    <div class=\"container\">\n        <div class=\"grid grid--size12 \">\n            <div class=\"Banner__content grid--size5Tp\">\n                                    <h1 class=\"Banner__title\">Autoimmune diagnostics<\/h1>\n                \n                                    <div class=\"Banner__logo\">\n                        \n    <picture\n        style=\"padding-top: 100%\"         class=\"Picture \"\n    >\n        <img decoding=\"async\"\n                src=\"\"\n                        data-src=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/04\/Autoimmundiagnostik.svg\"                class=\"lazyload Picture__image\"\n                alt=\"\"\n            title=\"Autoimmundiagnostik\"\/>\n\n        \n        <noscript>\n            <img decoding=\"async\" src=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/04\/Autoimmundiagnostik.svg\" alt=\"\" title=\"Autoimmundiagnostik\"\/>\n        <\/noscript>\n    <\/picture>\n\n                        <\/div>\n                \n                \n                \n\n            <\/div>\n            <div class=\"grid--size12 grid--size7Tp\">\n                                                    <div class=\"Banner__image\">\n                        \n    <picture\n                class=\"Picture Banner__picture Picture--hero\"\n    >\n        <img decoding=\"async\"\n                src=\"\"\n                        data-srcset=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280.png 2048w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-768x576.png 768w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-1536x1152.png 1536w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-1600x1200.png 1600w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-1024x768.png 1024w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-800x600.png 800w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-600x450.png 600w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-400x300.png 400w\"                class=\"lazyload Picture__image\"\n                alt=\"\"\n            title=\"ACA und n. Envelope 1280\"\/>\n\n        \n        <noscript>\n            <img decoding=\"async\" src=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-1024x768.png\" alt=\"\" title=\"ACA und n. Envelope 1280\"\/>\n        <\/noscript>\n    <\/picture>\n\n                        <\/div>\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n    <div class=\"container\">\n        <div class=\"Breadcrumb\">\n    <ul class=\"Breadcrumb__list\" itemscope itemtype=\"https:\/\/schema.org\/BreadcrumbList\">\n        \n                <li itemprop=\"itemListElement\" itemscope itemtype=\"http:\/\/schema.org\/ListItem\" class=\"Breadcrumb__item breadcrumb__item--home\">\n        <a itemprop=\"item\" href=\"https:\/\/www.laborberlin.com\/en\/\" class=\"Breadcrumb__link\">\n            <span itemprop=\"name\">Labor Berlin<\/span>\n        <\/a>\n        <meta itemprop=\"position\" content=\"1\" \/>\n    <\/li>\n    \n                <li itemprop=\"itemListElement\" itemscope itemtype=\"http:\/\/schema.org\/ListItem\" class=\"Breadcrumb__item breadcrumb__item--current\">\n        <a itemprop=\"item\" href=\"https:\/\/www.laborberlin.com\/en\/wp-json\/wp\/v2\/departments\/16094\/\" class=\"Breadcrumb__link\">\n            <span itemprop=\"name\">Department<\/span>\n        <\/a>\n        <meta itemprop=\"position\" content=\"2\" \/>\n    <\/li>\n        <\/ul>\n<\/div>\n    <\/div>\n\n\n<div class=\"Module Text Background Background--\" >\n    <div class=\"container\">\n        \n\n                                <div class=\"Text__content\">\n                <p>The Department of Autoimmune Diagnostics emerged from several individual laboratories at Charit\u00e9 and Vivantes.<\/p>\n<p>Autoimmune diagnostics services today include<\/p>\n<ul>\n<li>the entire laboratory diagnostics of patients with autoimmune diseases using state-of-the-art laboratory and immunodiagnostics,<\/li>\n<li>the support of publicly funded third-party projects and<\/li>\n<li>participation in industry-sponsored and investigator-initiated studies.<\/li>\n<\/ul>\n            <\/div>\n            <\/div>\n<\/div>\n\n\n\n\n<div class=\"Module AccordionModule Background Background--autoimmundiagnostik\" >\n    <div class=\"container\">\n        \n        <div class=\"Accordion\">\n                            <ul role=\"presentation\" class=\"Accordion__list\">\n                                                                    <li class=\"Accordion__item\" id=\"methods-and-equipment\">\n                            <button role=\"heading\" aria-expanded=\"false\" class=\"Accordion__title\" type=\"button\">\n                                Methods and equipment                            <\/button>\n\n                            <div class=\"Accordion__wrapper\">\n                                <div class=\"Accordion__content\">\n                                                                                                                                                                        <p>Autoimmune diagnostics currently determines around 140 parameters using the following methods:<\/p>\n<ul>\n<li>Immunofluorescence<\/li>\n<li>ELISA<\/li>\n<li>Immunoblot<\/li>\n<li>PCR<\/li>\n<li>Microarray<\/li>\n<\/ul>\n<p>The equipment includes all devices required for parameter determination, for example:<\/p>\n<ul>\n<li>Immunofluorescence microscopy (IF)<\/li>\n<li>Automatic preparation of slides for IF microscopy<\/li>\n<li>Aklides (for electronic evaluation of IF slides)<\/li>\n<li>Microplate reader<\/li>\n<li>Laboratory machines<\/li>\n<li>ELISA<\/li>\n<li>Blot-Master<\/li>\n<li>Blot-Scanner<\/li>\n<li>PCR-Cycler<\/li>\n<li>Microarray-Scanner<\/li>\n<\/ul>\n                                                                                                                                                                                \n                                                                                                    <ul class='grid grid--size6Tp'>\n                                                                                                                    <li class=\"mar--b3\">\n                                                                \n    <picture\n        style=\"padding-top: 75%\"         class=\"Picture \"\n    >\n        <img decoding=\"async\"\n                src=\"\"\n                        data-srcset=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280.png 2048w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-768x576.png 768w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-1536x1152.png 1536w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-1600x1200.png 1600w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-1024x768.png 1024w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ACA-und-n.-Envelope-1280-800x600.png 800w, 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Envelope 1280\"\/>\n        <\/noscript>\n    <\/picture>\n\n    \n                                                                                                                            <\/li>\n                                                                                                                    <li class=\"mar--b3\">\n                                                                \n    <picture\n        style=\"padding-top: 75%\"         class=\"Picture \"\n    >\n        <img decoding=\"async\"\n                src=\"\"\n                        data-srcset=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/feingr-Mitose2.png 2048w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/feingr-Mitose2-768x576.png 768w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/feingr-Mitose2-1536x1152.png 1536w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/feingr-Mitose2-1600x1200.png 1600w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/feingr-Mitose2-1024x768.png 1024w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/feingr-Mitose2-800x600.png 800w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/feingr-Mitose2-600x450.png 600w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/feingr-Mitose2-400x300.png 400w\"                class=\"lazyload Picture__image\"\n                alt=\"\"\n            title=\"feingr + Mitose2\"\/>\n\n        \n        <noscript>\n            <img decoding=\"async\" src=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/feingr-Mitose2-1024x768.png\" alt=\"\" title=\"feingr + Mitose2\"\/>\n        <\/noscript>\n    <\/picture>\n\n    \n                                                                                                                            <\/li>\n                                                                                                                    <li class=\"mar--b3\">\n                                                                \n    <picture\n        style=\"padding-top: 75%\"         class=\"Picture \"\n    >\n        <img decoding=\"async\"\n                src=\"\"\n                        data-srcset=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/homogen7.png 2048w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/homogen7-768x576.png 768w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/homogen7-1536x1152.png 1536w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/homogen7-1600x1200.png 1600w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/homogen7-1024x768.png 1024w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/homogen7-800x600.png 800w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/homogen7-600x450.png 600w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/homogen7-400x300.png 400w\"               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https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Jo-1-AKs-768x576.png 768w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Jo-1-AKs-1536x1152.png 1536w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Jo-1-AKs-1600x1200.png 1600w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Jo-1-AKs-1024x768.png 1024w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Jo-1-AKs-800x600.png 800w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Jo-1-AKs-600x450.png 600w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Jo-1-AKs-400x300.png 400w\"                class=\"lazyload Picture__image\"\n                alt=\"\"\n            title=\"Jo-1-AKs\"\/>\n\n        \n        <noscript>\n            <img decoding=\"async\" src=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Jo-1-AKs-1024x768.png\" alt=\"\" title=\"Jo-1-AKs\"\/>\n        <\/noscript>\n    <\/picture>\n\n    \n                                                                                                                            <\/li>\n                                                                                                            <\/ul>\n                                                                                                                                                                                                        <\/div>\n                            <\/div>\n                        <\/li>\n                                                                    <li class=\"Accordion__item\" id=\"interpretation-of-the-measurement-results\">\n                            <button role=\"heading\" aria-expanded=\"false\" class=\"Accordion__title\" type=\"button\">\n                                Interpretation of the measurement results                            <\/button>\n\n                            <div class=\"Accordion__wrapper\">\n                                <div class=\"Accordion__content\">\n                                                                                                                                                                        <h3><strong>Interpretation of the measurement results<\/strong><\/h3>\n<p>The principle of immunological detection techniques used in autoimmune diagnostics is the antigen-antibody reaction in which antigen (Ag) and antibody (Ak) form a specific, reversible bond. The methods currently used in autoimmune diagnostics include indirect immunofluorescence (IIFT), enzyme-linked immunoassay (EIA) and immunoblotting\/line immunoassay (LIA).<\/p>\n<h3><strong>Indirect immunofluorescence on HEp-2 cells (HEp-2 IFT)<\/strong><\/h3>\n<p>(Previously: antinuclear autoantibodies, ANA)<\/p>\n<p>The determination of autoantibodies using indirect immunofluorescence (IFT) is an essential part of the diagnosis and classification of a number of autoimmune diseases. Apart from the qualitative statement &#8220;negative&#8221; or &#8220;positive&#8221;, this study provides further valuable information. In addition to the intensity of the reaction, which is caused by the amount of antibodies present and represented as a titer, the autoantibodies can cause a variety of fluorescence patterns relating to the nucleus, the cytoplasm and the mitotic stages of the cells examined.<\/p>\n<p>HEp-2 cells are used as a substrate for screening for organ-nonspecific autoantibodies. The test results can sometimes vary, both between individual employees of a laboratory and between different laboratories. The causes of these deviations can be objective, e.g. different reagents, or subjective, due to different empirical values.<\/p>\n<p>The &#8220;ICAP&#8221; initiative (International Consensus on Antinuclear Antibody Patterns (ANA)) was founded with the aim of finding a uniform nomenclature for various fluorescence patterns that can be recognized and described using the indirect immunofluorescence technique on HEp-2 cells. As this classification system includes nuclear, mitotic and cytoplasmic antibodies, the term &#8220;HEp-2 cell IFT&#8221; is recommended for the screening test.<\/p>\n<p>Further detailed information on the classification and nomenclature is available under the following link:<\/p>\n<p><a href=\"https:\/\/anapatterns.org\/\">https:\/\/anapatterns.org\/<\/a><\/p>\n<p>The clinical relevance of the detected autoantibodies should always be assessed in the context of the suspected clinical diagnosis and usually confirmed or supplemented by another method.<\/p>\n<p>&nbsp;<\/p>\n<p>Literature:<\/p>\n<p>E.K.L. Chan, J. Damoiseaux, O.G. Carballo, K. Conrad, W. de Melo Cruvinel, P.L.C. Francescantonio, M.J. Fritzler, I. Garcia-De La Torre, M. Herold, T. Mimori, M. Satoh, C.A. von M\u00fchlen, and L.E.C. Andrade. Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns (ICAP) 2014-2015 (Front. Immunol. 2015, Aug 20;6:412).<\/p>\n<h3><strong>Enzyme-linked Immunoassay (EIA)<\/strong><\/h3>\n<p>Usually more sensitive than IIFT, which may be associated with a loss of specificity. Results may differ from those determined by another method. The significance of the different methods and their results must always be assessed with the clinical picture of the patient, as the structure or presentation of the antigen can vary individually depending on the method, as can the time course and level of antibodies, or their fall and rise.<\/p>\n<h3><strong>Immunoblotting, Line Immunoassay (LIA)<\/strong><\/h3>\n<p>This method can be helpful if several antibodies are to be detected simultaneously, e.g. onconeuronal antibodies. The results obtained with this method are quantitative or semi-quantitative:<br \/>\n&#8211; negative<\/p>\n<p>(+) questionable\/limited<\/p>\n<p>+ weakly positive<\/p>\n<p>++ positive<\/p>\n<p>+++ strongly positive<\/p>\n<p>In principle, a higher sensitivity of the laboratory tests also means a higher diagnostic sensitivity, but at the same time a lower specificity. The evaluation must take into account that there is currently no gold standard method in this area of diagnostics. The lack of standardization of methods can cause different results in different laboratories and large differences in the implementation of external quality controls (interlaboratory comparisons). Furthermore, the individual methods are not comparable in terms of their informative value.<\/p>\n<p>The critical difference, which depends on the precision of the method (standard deviation, SD), is of great importance for progression assessment. The difference between two determinations can be described as statistically significant if two measurement results differ by at least +3SD.<\/p>\n<p>In summary, the use of different methods, which can complement each other, is necessary for diagnosis. An effective and successful diagnosis can only be achieved with the help of a link between patient, doctor and laboratory, whereby the clinical manifestation of the disease plays an essential role in the interpretation of the laboratory results.<\/p>\n<p>&nbsp;<\/p>\n<p>Literature:<\/p>\n<p>K. D\u00f6rner: Klinische Chemie und H\u00e4matologie, 2009<br \/>\nA. Hall et al.: Clinical Immunology, Fundamental of Biomedical Science, 2016<br \/>\nB. Neumeister, B. O. B\u00f6hm: Klinikleitfaden: Labordiagnostik, 2015<br \/>\nK. M. Pollard: Autoantibodies and Autoimmunity, 2006<br \/>\nG. Spickett: Oxford Handbook of Clinical Immunology and allergy, 2020<\/p>\n<p><strong>contact: <a href=\"mailto:autoimmundiagnostik@laborberlin.com\">autoimmundiagnostik@laborberlin.com<\/a><\/strong><\/p>\n                                                                                                                                                        <\/div>\n                            <\/div>\n                        <\/li>\n                                                                    <li class=\"Accordion__item\" id=\"research\">\n                            <button role=\"heading\" aria-expanded=\"false\" class=\"Accordion__title\" type=\"button\">\n                                Research                            <\/button>\n\n                            <div class=\"Accordion__wrapper\">\n                                <div class=\"Accordion__content\">\n                                                                                                                                                                        <h2>Integrated in research<\/h2>\n<p>The Department of Autoimmune Diagnostics is involved in numerous research projects in the clinical and industrial sectors. New important assays for the determination of autoantibodies have been developed as part of these projects, for example:<\/p>\n<ul>\n<li>Anti-MCV-ELISA<\/li>\n<li>POCT-Assay RheumaChec<\/li>\n<li>Anti-dsDNA-ELISA<\/li>\n<li>Anti-PR3-hn-hr-ELISA<\/li>\n<li>Epitope mapping for therapy monitoring of biologicals in rheumatoid arthritis (RA)<\/li>\n<\/ul>\n<p>In the national multi-center study Hit-Hard, which was initiated by the Medical Clinic with a focus on rheumatology and clinical immunology, the reference laboratory. The laboratory is also part of two joint research projects and contributes to numerous therapy studies.<\/p>\n                                                                                                                                                        <\/div>\n                            <\/div>\n                        <\/li>\n                                    <\/ul>\n                    <\/div>\n    <\/div>\n<\/div>\n\n\n<div class=\"Module TeaserColumns Background Background--warmGrey\" >\n    <div class=\"container\">\n            <Header class=\"Module__header\">\n                    <h2>Team<\/h2>\n        \n        \n        \n\n    <\/Header>\n\n\n        \n                    <div class=\"TeaserColumns__list grid grid--size12  grid--size3T grid--size6Tp\">\n                                    <div class=\"TeaserColumns__item\">\n                                                    <span class=\"Topline TeaserColumns__topline\">Prof. Dr. Gerhard Kr\u00f6nke<\/span>\n                        \n                                                    <div class=\"TeaserColumns__image TeaserColumns__image--fourColumns\">\n                                \n    <picture\n                class=\"Picture  Picture--hero\"\n    >\n        <img decoding=\"async\"\n                src=\"\"\n                        data-srcset=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Portrait-Gerhard-Kroenke-Charite__ID_12835____Charite_l_Artur_Krutsch-scaled.jpg 2560w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Portrait-Gerhard-Kroenke-Charite__ID_12835____Charite_l_Artur_Krutsch-768x549.jpg 768w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Portrait-Gerhard-Kroenke-Charite__ID_12835____Charite_l_Artur_Krutsch-1536x1097.jpg 1536w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Portrait-Gerhard-Kroenke-Charite__ID_12835____Charite_l_Artur_Krutsch-2048x1463.jpg 2048w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Portrait-Gerhard-Kroenke-Charite__ID_12835____Charite_l_Artur_Krutsch-1600x1143.jpg 1600w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Portrait-Gerhard-Kroenke-Charite__ID_12835____Charite_l_Artur_Krutsch-1024x731.jpg 1024w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Portrait-Gerhard-Kroenke-Charite__ID_12835____Charite_l_Artur_Krutsch-800x571.jpg 800w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Portrait-Gerhard-Kroenke-Charite__ID_12835____Charite_l_Artur_Krutsch-600x429.jpg 600w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Portrait-Gerhard-Kroenke-Charite__ID_12835____Charite_l_Artur_Krutsch-400x286.jpg 400w\"                class=\"lazyload Picture__image\"\n                alt=\"\"\n            title=\"Portrait-Gerhard-Kr\u00f6nke-Charit\u00e9\"\/>\n\n                    <div class=\"Picture__tooltip\">\n                <div class=\"Picture__tooltipIcon\">\u00a9<\/div>\n                <div class=\"Picture__tooltipContent\">\n                    \u00a9 Charit\u00e9 | Artur Krutsch                 <\/div>\n            <\/div>\n        \n        <noscript>\n            <img decoding=\"async\" src=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/Portrait-Gerhard-Kroenke-Charite__ID_12835____Charite_l_Artur_Krutsch-3200x2286.jpg\" alt=\"\" title=\"Portrait-Gerhard-Kr\u00f6nke-Charit\u00e9\"\/>\n        <\/noscript>\n    <\/picture>\n\n                                <\/div>\n                        \n                                                    <p>Director Autoimmune Diagnostics<\/p>\n                        \n                                                    \n                            <a href=\"javascript:mailto('nbjmup;hfsibse\/lspfolfAdibsjuf\/ef');\" class=\"TeaserColumns__more More\">Send e-mail<\/a>\n                                            <\/div>\n                                    <div class=\"TeaserColumns__item\">\n                                                    <span class=\"Topline TeaserColumns__topline\">Dr. Ivana B\u00fcttnerova<\/span>\n                        \n                                                    <div class=\"TeaserColumns__image TeaserColumns__image--fourColumns\">\n                                \n    <picture\n                class=\"Picture  Picture--hero\"\n    >\n        <img decoding=\"async\"\n                src=\"\"\n                        data-srcset=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/04\/Team_w.jpg 753w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/04\/Team_w-600x452.jpg 600w, https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/04\/Team_w-400x301.jpg 400w\"                class=\"lazyload Picture__image\"\n                alt=\"\"\n            title=\"Team_w\"\/>\n\n        \n        <noscript>\n            <img decoding=\"async\" src=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/04\/Team_w.jpg\" alt=\"\" title=\"Team_w\"\/>\n        <\/noscript>\n    <\/picture>\n\n                                <\/div>\n                        \n                                                    <p>Head of Autoimmune Diagnostics<\/p>\n                        \n                                                    \n                            <a href=\"javascript:mailto('nbjmup;jwbob\/cvfuuofspwbAmbcpscfsmjo\/dpn');\" class=\"TeaserColumns__more More\">Send e-mail<\/a>\n                                            <\/div>\n                                    <div class=\"TeaserColumns__item\">\n                                                    <span class=\"Topline TeaserColumns__topline\">Diana Mielke<\/span>\n                        \n                                                    <div class=\"TeaserColumns__image TeaserColumns__image--fourColumns\">\n                                \n    <picture\n                class=\"Picture  Picture--hero\"\n    >\n        <img decoding=\"async\"\n                src=\"\"\n                        data-src=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ChaperonCHAPERON_0619_LAB_BERLIN_1540-3200x2133.jpg\"                class=\"lazyload Picture__image\"\n                alt=\"\"\n            title=\"Diana_Mielke\"\/>\n\n        \n        <noscript>\n            <img decoding=\"async\" src=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/2020\/01\/ChaperonCHAPERON_0619_LAB_BERLIN_1540-3200x2133.jpg\" alt=\"\" title=\"Diana_Mielke\"\/>\n        <\/noscript>\n    <\/picture>\n\n                                <\/div>\n                        \n                                                    <p>Leitende MTLA Autoimmundiagnostik<\/p>\n                        \n                                                    \n                            <a href=\"javascript:mailto('nbjmup;ejbob\/njfmlfAmbcpscfsmjo\/dpn');\" class=\"TeaserColumns__more More\">Send e-mail<\/a>\n                                            <\/div>\n                            <\/div>\n            <\/div>\n<\/div>\n\n\n\n<div class=\"Module TeaserColumns Background Background--autoimmundiagnostik\" >\n    <div class=\"container\">\n            <Header class=\"Module__header\">\n                    <h2>contact<\/h2>\n        \n        \n        \n\n    <\/Header>\n\n\n        \n                    <div class=\"TeaserColumns__list grid grid--size12  grid--size3T grid--size6Tp\">\n                                    <div class=\"TeaserColumns__item\">\n                                                    <span class=\"Topline TeaserColumns__topline\">Labor Berlin &#8211; Charit\u00e9 Vivantes GmbH<\/span>\n                        \n                        \n                                                    <p>Department of Autoimmune Diagnostics<br \/>\nSylter Stra\u00dfe 2<br \/>\n13353 Berlin<\/p>\n<p>phone: +49 (30) 40 50 26-800<br \/>\nfax: +49 (30) 40 50 26-615<\/p>\n                        \n                                            <\/div>\n                            <\/div>\n            <\/div>\n<\/div>\n\n\n\n<div class=\"Module DownloadsList\" >\n    <div class=\"container\">\n            <Header class=\"Module__header Module__header--wide\">\n                    <h2>Requisition slips<\/h2>\n        \n                    <p>Services for private patients, self-paying patients or elective laboratory services will be invoiced by LABOR BERLIN directly to the respective payer, unless otherwise agreed with the sender. For this purpose, the sender shall forward the necessary patient data to LABOR BERLIN and ensure that the patients are informed about the possible forwarding of laboratory orders to LABOR BERLIN and the associated organizational measures, including billing by a private medical clearing office, in the manner prescribed by law and consent to this. The legal requirements with regard to the free choice of doctor are taken into account. We would like to point out that, in accordance with the provisions of the German Hospital Remuneration Act (KHEntgG), external elective laboratory services must be ordered by the sender on a case-by-case basis and specifically by the elective physicians concerned.<\/p>\n        \n        \n\n    <\/Header>\n\n\n                            \n                \n                                                                                <ul class=\"DownloadsItem grid grid--size12 grid--size4Tp\">\n    \n        \n                                <li class=\"DownloadsItem__item\">\n                <h3>Requisition slip for autoimmune diagnostics<\/h3>\n                                <a class=\"More More--download DownloadsItem__itemLink\" target=\"_blank\" href=\"https:\/\/www.laborberlin.com\/wp-content\/uploads\/260220_AUT-Anforderungsschein_001-14.pdf\">pdf<\/a>\n            <\/li>\n        \n    <\/ul>\n\n                                    \n                                        <\/div>\n<\/div>\n","protected":false},"featured_media":0,"template":"","class_list":["post-16094","departments","type-departments","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.7 - 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