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Sysmex XN-Based Evaluation of the Diagnostic Performance of High-Fluorescent Cells From CSF as a Supportive Diagnostic Criterion in Neurological Diseases
10.04.25 | In a study with nearly 300 cerebrospinal fluid samples, employees of the Department of Laboratory Medicine were able to demonstrate the diagnostic value of the automatic analysis of highly fluorescent cells (HFC) using fluorescence flow cytometry. The automatic cell differentiation, which is carried out around the clock, shows a 95% agreement with manual microscopy and an 80% concordance for HFC. The determination of HFC alone allowed a correct clinical stratification with up to 70% of cases with hemorrhage, inflammation and neoplasia. These results emphasize the potential of HFC as a valuable parameter in neurological diagnostics.
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Labor Berlin relies on mass spectrometry by Roche
07.04.25 | Milestone in diagnostics
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Roche Diagnostics and Labor Berlin announce the installation of the world’s first fully automated system for mass spectrometry (cobas® i 601 Mass Spec solution). It will enable even faster diagnoses 24/7 and significantly improve the quality of patient care. -
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TGFβ links EBV to multisystem inflammatory syndrome in children
20.03.25 | Employees of Labor Berlin supported clinicians at Charité in discovering the cause of a severe inflammatory syndrome called MIS-C that can occur in some children and adolescents after a SARS-CoV-2 infection. The syndrome is characterized by impaired activation of memory T cells due to high TGFβ concentrations. This dysfunction leads to reactivation of the Epstein-Barr virus and an increased inflammatory reaction, which can be reversed by blocking TGFβ. Targeted treatment with TGFβ blockers is being considered as a possible therapeutic option to improve T-cell reactivity and prevent both EBV reactivation and the associated hyperinflammation. The findings were published in the renowned journal Nature.
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Advanced disease and CD8+ TEMRA cells predict severe infections in multiple myeloma
28.02.25 | In a prospective study, staff from the Departments of Immunology and Haematology & Oncology, in collaboration with clinicians from Charité, investigated risk factors for severe infections in patients with monoclonal gammopathy of undetermined significance (MGUS) and newly diagnosed multiple myeloma (NDMM). Almost half of these patients suffered infections within the first year after diagnosis. Particularly advanced disease stages and increased concentrations of CD8+ TEMRA cells (‘terminally differentiated effector memory T cells re-expressing CD45RA’) were significantly associated with an increased risk of infection. The developed risk assessment model PREDICT-SID, which integrates clinical, laboratory and immunological parameters, was able to identify patients with a sensitivity of 93% and a specificity of 80% (AUC 0.96) who are at high risk of early severe infections and may therefore require more intensive preventive and therapeutic measures.
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A candidate reference measurement procedure for the quantification of α-synuclein in cerebrospinal fluid using an SI traceable primary calibrator and multiple reaction monitoring
29.01.25 | Neurodegenerative diseases such as Parkinson’s disease and Lewy body dementia show α-synuclein aggregation in the brain as a common key feature. Due to considerable problems with the standardisation of previous α-synuclein measurement methods, caused by the insufficient specificity and measurement accuracy of the antibodies used in conventional immunoassays, members of the Department of Immunology have developed a new reference measurement method (RMP) in an international initiative. This method, which is based on an internationally standardised (SI) calibrator and the use of liquid chromatography-tandem mass spectrometry (LC-MS/MS), enables reliable and standardised quantification of α-synuclein in cerebrospinal fluid in order to ensure comparable measurement results for patient care worldwide.
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Sysmex XN-Based Evaluation of the Diagnostic Performance of High-Fluorescent Cells From CSF as a Supportive Diagnostic Criterion in Neurological Diseases
Benedict Schwarz, Christopher Hardt, Katharina Friedrich, Monika Prpic, Anja Osterloh, Frank L Heppner, Klemens Ruprecht, Kai Kappert, Amir Jahic International Journal of Laboratory Medicine, 2025 March 20 Doi: 10.1111/ijlh.14466 PMID: 40112826
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TGFβ links EBV to multisystem inflammatory syndrome in children
Carl Christoph Goetzke, Mona Massoud, Stefan Frischbutter, Gabriela Maria Guerra, Marta Ferreira-Gomes, Frederik Heinrich, Anne Sae Lim von Stuckrad, Sebastian Wisniewski, Jan Robin Licha, Marina Bondareva, Lisa Ehlers, Samira Khaldi-Plassart, Etienne Javouhey, Sylvie Pons, Sophie Trouillet-Assant, Yasemin Ozsurekci, Yu Zhang, Maria Cecilia Poli, Valentina Discepolo, Andrea Lo Vecchio, Bengü Sahin, Murielle Verboom, Michael Hallensleben, Anja Isabelle Heuhsen, Camila Astudillo, Yazmin Espinosa, Maria Cecilia Vial Cox, Kerry Dobbs, Ottavia M. Delmonte, Gina A. Montealegre Sanchez, Mary Magliocco, Karyl Barron, Jeffrey Danielson, Lev Petrov, Nadine Unterwalder, Birgit Sawitzki, Mareen Matz, Katrin Lehmann, Alexander Gratopp, Horst von Bernuth, Lisa-Marie Burkhardt, Niklas Wiese, Lena Peter, Michael Schmueck-Henneresse, Leila Amini, Marcus Maurer, Jobst Fridolin Roehmel, Benjamin E. Gewurz, Lael M. Yonker, Mario Witkowski, Andrey Kruglov, Marcus Alexander Mall, Helen C. Su, Seza Ozen, Andreas Radbruch, Alexandre Belot, Pawel Durek, Tilmann Kallinich, Mir-Farzin Mashreghi Nature 2025 March 12 Doi: 10.1038/s41586-025-08697-6 PMID: 40074901
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Advanced disease and CD8+ TEMRA cells predict severe infections in multiple myeloma
Eva Tranter, David Busch, Clarissa Heck, Igor Wolfgang Blau, Axel Nogai, Phillip Schiele, Christian Meisel, Lars Bullinger, Marco Frentsch, Il-Kang Na Frontiers in Immunology 2025 Feb 12:16:1532645 Doi: 10.3389/fimmu.2025.1532645 PMID: 40013147
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A candidate reference measurement procedure for the quantification of α-synuclein in cerebrospinal fluid using an SI traceable primary calibrator and multiple reaction monitoring
Leran Zhang, Eva Illes-Toth, Adam Cryar, Giles Drinkwater, Lucia Di Vagno, Marie-Laure Pons, Julia Mateyka, Bryan McCullough, Eli Achtar, Cailean Clarkson, Laura Göschel, Peter Körtvélyessy, Chris Mussell, Christopher J Hopley, Agnes Flöel, Christophe Hirtz, Sylvain Lehmann , Milena Quaglia Analyst, 2024 Sep 23;149(19):4842-4850 Doi: 10.1039/d4an00634h PMID: 39041602
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Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling
Jana Ihlow, Livius Penter, Lam Giang Vuong, Philip Bischoff, Benedikt Obermayer, Alexandra Trinks, Olga Blau, Anke Behnke, Thomas Conrad, Markus Morkel, Catherine J Wu, Jörg Westermann, Lars Bullinger, Ann-Christin von Brünneck, Nils Blüthgen, David Horst, Samantha D Praktiknjo Med, 6, 1–9, 2025 Doi: 10.1016/j.medj.2024.11.001 PMID: 39644889
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A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy
Davide Bindellini, Robin Michelet, Linda B S Aulin, Johanna Melin, Uta Neumann, Oliver Blankenstein, Wilhelm Huisinga, Martin J Whitaker, Richard Ross, Charlotte Kloft Journal of Pharmacokinetics and Pharmacodynamics, 2024 December; 51(6):809-824. Doi: 10.1007/s10928-024-09934-7 PMID: 38977635
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Endocarditis associated with contamination of cardiovascular bioprostheses with Mycobacterium chelonae: a collaborative microbiological study
Judith Kikhney, Inna Friesen, Solveigh Wiesener, Laura Kursawe, Christoph Loddenkemper, Josef Zündorf, Beate Häuser, Esther P Cónsul Tejero, Dinah V Schöning, Kurosh Sarbandi, Doris Hillemann, Martin Kuhns, Miriam S Stegemann, Frieder Pfäfflin, Frank-Rainer Klefisch, Volker Düsterhöft, Sebastian Haller, Anja V Laer, Tim Eckmanns, Emmanuelle Cambau, Sarah Tschudin-Sutter, Barbara Hasse, Anette Friedrichs, Bernd Panholzer, Walter Eichinger, Petra Gastmeier, Volkmar Falk, Annette Moter Lancet Microbe, 24 October 2024:100934 doi: 10.1016/j.lanmic.2024.06.001 PMID: 39491876
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Simplified preanalytical laboratory procedures for therapeutic drug monitoring (TDM) in patients treated with high-dose methotrexate (HD-MTX) and glucarpidase
Franz L. Knörnschild, Sven Liebig, Peggy Kießling, Monika Prpic, Tehyung Kim, Ulrich Keller, Kai Kappert, Stefan Schwartz, Amir Jahic Blood Cancer Journal, 16 September 2024 doi: 10.1515/cclm-2024-052 PMID: 38997789
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Therapy-related AML: long-term outcome in a large cohort of AML-patients with intensive and non-intensive therapy
Sophia Gross, Jana Ihlow, Leonie Busack, Kacper Adamiak, Jens Schrezenmeier, Julia Jesse, Michaela Schwarz, Anne Flörcken, Lam Giang Vuong, Kathrin Rieger, Jan Krönke, Philipp le Coutre, Vivien Boldt, Ann-Christin von Brünneck, David Horst, Thomas Burmeister, Igor-Wolfgang Blau, Ulrich Keller, Lars Bullinger, Jörg Westermann Blood Cancer Journal, 16 September 2024 doi: 10.1038/s41408-024-01140-5 PMID: 39284846
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Amplification of autoimmune organ damage by NKp46-activated ILC
Stylianos-Iason Biniaris-Georgallis, Tom Aschman, Katerina Stergioula, Frauke Schreiber, Vajiheh Jafari, Anna Taranko, Tejal Karmalkar, Ana Kasapi, Tihana Lenac Rovis, Vedrana Jelencic, David A. Bejarano, Lea Fabry, Michail Papacharalampous, Irene Mattiola, Martina Molgora, Jinchao Hou, Karolin W. Hublitz, Frederik Heinrich, Gabriela Maria Guerra, Pawel Durek, Giannino Patone, Eric Lars-Helge Lindberg, Henrike Maatz, Oliver Hölsken, Gerhard Krönke, Arthur Mortha, Reinhard E. Voll, Alexander J. Clarke, Anja E. Hauser, Marco Colonna, Kevin Thurley, Andreas Schlitzer, Christoph Schneider, Efstathios G. Stamatiades, Mir-Farzin Mashreghi, Stipan Jonjic, Norbert Hübner, Andreas Diefenbach, Masatoshi Kanda & Antigoni Triantafyllopoulou Nature 2024 Aug 13 doi: 10.1038/s41586-024-07907-x PMID: 39137897
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