Endocrinology & Metabolism

Thanks to the laboratory’s expertise, the measurement methods are selected strictly according to criteria of clinical relevance and in accordance with the clinical question. If desired, the parameters offered can be tested and maintained across the entire age spectrum – from newborn to old age. This applies to all reference ranges and assessment criteria. The clinical specialists are closely involved. This ensures rapid and continuous exchange between the laboratory and clinical practice.

In the specialist department, all findings are medically examined by clinically active specialists and – if necessary – individually assessed. The end result is not just the laboratory value with its reference ranges. If necessary, a summary assessment of all the requested parameters is carried out with information on differential diagnoses and possible further diagnostics. For queries in special cases, the specialists can also be contacted by telephone.

In the field of metabolic diagnostics, various intermediate and end products of the metabolism are measured in order to draw conclusions about the function of metabolic processes in the body. A comprehensive range of tests on the metabolism of carbohydrates, proteins, nucleic acids, fats and other selected metabolic and neuro-metabolic processes is offered here.

The department emerged from the former metabolic laboratory of the Children’s Hospital, which is why the focus of the examination program is still on the diagnosis and monitoring of patients with very rare, congenital disorders of the intermediary metabolism.

Close cooperation with the clinical specialists at the Charité is a central component of the concept, particularly in the field of metabolic diagnostics. Together with Dr. Oliver Blankenstein (Head of Diagnostics and Newborn Screening), the metabolic team also ensures the connection, diagnosis and consultation of abnormal findings in newborn screening. This enables us to provide a comprehensive range of metabolic diagnostics services for our consignors. This includes:

1. Pre-analytical consultation
2. Special analysis in the laboratory
3. Medical diagnosis by the metabolic specialists, taking into account the available clinical information
4. Advice on further diagnostics and, if necessary, therapy suggestions
   Methodologically, metabolic diagnostics is characterized by a high proportion of manual and sometimes very complex examination procedures in order to reliably detect rare and unknown metabolites. In addition to chromatographic and photometric methods, HPLC is also used in combination with gas chromatographic (GC-MS) and mass spectrometric (LC-MS/MS) analysis methods.

Newborn screening is provided by Labor Berlin in cooperation with Charité – Universitätsmedizin Berlin.

Lesen Sie ausführliche Informationen dazu unter: http://screening.charite.de.