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Award-winning: Labor Berlin named one of “Berlin’s Best Employers & Training Companies 2025”
22.09.25 | Labor Berlin was awarded by Tagesspiegel as part of the study “Berlin’s Best Employers & Training Companies 2025.”
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We are officially one of the top employers in the capital and are allowed to bear the coveted seal of quality. This sends a strong signal to our employees and anyone who wants to join us. -
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Detection of autoantibodies against Interferon Type I in patients with autochthonous West Nile Virus encephalitis
19.09.25 | Employees at Labor Berlin, working together with clinicians at Charité, were able to detect neutralizing autoantibodies against type I interferons in severe autochthonous infections with West Nile virus encephalitis (WNV) in Berlin. These autoantibodies block the antiviral immune response, thereby promoting severe disease progression. In one case without these autoantibodies, the course of the disease was mild. Targeted screening for autoantibodies against type I interferons in cases of suspected WNV, especially in older patients, therefore appears to be recommended. The infections were caused by locally circulating virus strains and highlight the need for improved surveillance in Germany.
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Labor Berlin Diagnostics Compass
12.09.25 | Compact knowledge from our specialist departments
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With the Diagnostics Compass, Labor Berlin now offers a new information section for senders and those interested in medicine. The compact articles by our experts provide practical insights into current diagnostic issues—well-founded, precise, and presented in an understandable way.
Gain insights into laboratory medicine backgrounds, diagnostic developments, and complex interrelationships of current topics. Whether new biomarkers, innovative detection methods, or the clinical relevance of certain parameters. Gain insights into laboratory medicine, diagnostic developments, and complex interrelationships between current topics. Whether new biomarkers, innovative detection methods, or the clinical relevance of certain parameters—the Labor Berlin Diagnostics Compass can help medical professionals make informed decisions and provide evidence-based patient care. -
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Mein Labor Berlin opens second location in Berlin
09.09.25 | Mein Labor Berlin now with second location in Berlin Mitte
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We are constantly expanding our range of services for private individuals: since the beginning of September, our diagnostic services have also been available at the Eterno Health location in Berlin Mitte. In addition to comprehensive blood tests, 3D body analyses are now also available here – for a comprehensive assessment of individual health factors.
With Mein Labor Berlin, we offer people who want to actively monitor their health comprehensive medical analyses at the highest professional level – regardless of whether they have a referral from a doctor. -
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The expanding clinical utility of blood neurofilament light chain (bNfL): a multi-disciplinary diagnostic tool
09.09.25 | In a large-scale retrospective analysis of over 22,000 patients, employees of Labor Berlin, together with clinicians from Charité and the University of Gothenburg, were able to show that neurofilament light chain in blood (bNfL) is increasingly finding its way into clinical routine – not only in neurology, but also in cardiology, oncology, paediatrics, psychiatry and intensive care medicine. Starting from academic centres such as Charité, the marker is also becoming increasingly established in non-university clinics and practices. bNfL is proving particularly valuable as an indicator of neuroaxonal damage in diseases such as multiple sclerosis, amyotrophic lateral sclerosis, dementia, polyneuropathies and hypoxic brain damage following cardiac arrest in intensive care units. This significantly expands the range of applications for this biomarker beyond neurology and opens up new perspectives for diagnostics, prognosis and therapy monitoring in numerous medical disciplines.
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Labor Berlin among Germany’s innovation champions for the fourth time
26.8.25 | Labor Berlin was able to build on the innovative success of the top 100 German medium-sized companies in 2025 for the fourth time in a row. Since 2011, WirtschaftsWoche has been publishing the exclusive ranking, which analyzes the innovative strength of 4,000 medium-sized companies.
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Alzheimer-related biomarker p-Tau217
08.08.25 | Alzheimer-related biomarkers via blood sampling – Labor Berlin now offers minimally invasive, patient-centered care for Alzheimer’s diagnostics. Request p-Tau217 now as an individual health service (IGeL) or private medical service according to GOÄ. Further information can be found in our Diagnostics Kompass.
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Modern prostate cancer screening using dried blood
31.07.25 | Prostate cancer is by far the most common malignant tumor disease in men in Germany. For early detection, the recently updated S3 guideline no longer recommends a digital rectal exam. Labor Berlin now offers prostate cancer screening for private individuals using dried blood samples that can be taken at home.
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Soluble Urokinase Plasminogen Activator Receptor Predicts Survival and Hepatic Decompensation in Advanced Hepatocellular Carcinoma
01.08.25 | In collaboration with clinicians at Charité, employees at Labor Berlin were able to demonstrate in a multicenter retrospective study that elevated levels of soluble urokinase plasminogen activator receptor (suPAR) predict survival and the risk of liver decompensation in patients with advanced liver cancer undergoing immunotherapy. suPAR concentrations were closely linked to liver function, but not to tumor-related characteristics. This biomarker enables a more precise risk assessment within existing liver function classes (Child-Pugh) and could support individual treatment decisions in the future.
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Coordinated implementation of a conventional PCR assay to detect all Ebola and Marburg virus species in a European laboratory
03.07.25 | Together with scientists from Charité, employees from Labor Berlin have developed a PanFilo PCR test for the rapid detection of Ebola, Marburg and other filoviruses. In a second step, the test allows direct sequencing to identify both known and novel virus variants. In a Europe-wide validation study involving 15 laboratories, the method proved highly reliable and demonstrated its potential for use in the early phases of future outbreaks, even with previously unknown pathogens. At the same time, it became clear that greater standardization of diagnostics and sequencing between laboratories is necessary.
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New Chairman of the Supervisory Board
01.07.25 | Labor Berlin welcomes its new Chairman of the Supervisory Board Dr. Johannes Danckert, Chairman of the Management Board & Clinic Management of Vivantes Netzwerk für Gesundheit GmbH, as of July 1, 2025. We are very much looking forward to our continued cooperation and say “Welcome”. Dr. Danckert takes over from Astrid Lurati, Chief Financial and Infrastructure Officer of Charité, who has chaired our Supervisory Board since June 1, 2017. We would like to thank Ms. Lurati very much for the trusting cooperation over the past 8 years. She will remain with Labor Berlin as a member of the Supervisory Board.
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Serum neurofilament light chain and multimodal neuroprognostication after cardiac arrest – A retrospective cohort study
23.06.25 | Employees of Labor Berlin, together with clinicians from Charité, were able to show that the neurofilament light chain protein (NFL) in serum is a meaningful biomarker for the early neurological prognosis after a cardiac arrest. NFL values > 2000 pg/ml indicate an unfavourable neurological outcome with high specificity, while low values largely rule out severe brain damage. The addition of the biomarker NFL to established procedures such as EEG, NSE or CT significantly improves the overall predictive power.
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©Felix Petermann – Max Delbrück Center
Funding Cluster of Excellence ImmunoPreCept
10.06.25 | Preventing diseases instead of treating them
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Chronic diseases such as cancer or immune-mediated inflammation are on the rise worldwide – and therapies often take effect too late. This is precisely where ImmunoPreCept comes in: The new Cluster of Excellence headed by Charité – Universitätsmedizin Berlin is researching how the immune system maintains health – and what throws it out of balance. The aim is to identify causes before symptoms arise.
With Prof. Dr. Andreas Diefenbach, Director of our Department of Microbiology & Hygiene, as one of the spokespersons, ImmunoPreCept brings together cutting-edge research from immunology, systems biology and medicine – for the preventive medicine of tomorrow.
Start: January 2026, funded as part of the Excellence Strategy of the federal and state governments. -
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Inauguration of the world’s first fully automated mass spectrometry system
02.06.25 | Roche Diagnostics and Labor Berlin inaugurate the world’s first fully automated mass spectrometry system (cobas® i 601 Mass Spec solution) in a clinical laboratory. This innovative system at Labor Berlin marks a significant milestone in diagnostics by making clinical mass spectrometry testing accessible in routine laboratories. Franziska Giffey (Mayor & Senator for Economics, Energy and Public Enterprises of the State of Berlin) and Dr Thomas Schinecker (CEO, Roche Group) were among those invited to the inauguration ceremony.
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Comparative evaluation of multimarker algorithms for early-stage HCC detection in multicenter prospective studies
02.05.25 | As part of an international study involving over 1,000 patients for the early detection of hepatocellular carcinoma (HCC), employees at Labor Berlin were able to show that the new GAAD algorithm – based on gender, age, alpha-fetoprotein (AFP) and des-gamma-carboxyprothrombin (DCP or PIVKA II) – has the same high diagnostic accuracy as the established GALAD algorithm, which also includes the biomarker AFP-L3. Both algorithms reliably differentiate between early HCC and chronic liver disease (CLD), whereby the GAAD algorithm does not require the additional marker AFP-L3. GAAD thus represents a simplified, cheaper and yet effective method for HCC detection.
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Sysmex XN-Based Evaluation of the Diagnostic Performance of High-Fluorescent Cells From CSF as a Supportive Diagnostic Criterion in Neurological Diseases
10.04.25 | In a study with nearly 300 cerebrospinal fluid samples, employees of the Department of Laboratory Medicine were able to demonstrate the diagnostic value of the automatic analysis of highly fluorescent cells (HFC) using fluorescence flow cytometry. The automatic cell differentiation, which is carried out around the clock, shows a 95% agreement with manual microscopy and an 80% concordance for HFC. The determination of HFC alone allowed a correct clinical stratification with up to 70% of cases with hemorrhage, inflammation and neoplasia. These results emphasize the potential of HFC as a valuable parameter in neurological diagnostics.
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©Roche
Labor Berlin relies on mass spectrometry by Roche
07.04.25 | Milestone in diagnostics
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Roche Diagnostics and Labor Berlin announce the installation of the world’s first fully automated system for mass spectrometry (cobas® i 601 Mass Spec solution). It will enable even faster diagnoses 24/7 and significantly improve the quality of patient care. -
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TGFβ links EBV to multisystem inflammatory syndrome in children
20.03.25 | Employees of Labor Berlin supported clinicians at Charité in discovering the cause of a severe inflammatory syndrome called MIS-C that can occur in some children and adolescents after a SARS-CoV-2 infection. The syndrome is characterized by impaired activation of memory T cells due to high TGFβ concentrations. This dysfunction leads to reactivation of the Epstein-Barr virus and an increased inflammatory reaction, which can be reversed by blocking TGFβ. Targeted treatment with TGFβ blockers is being considered as a possible therapeutic option to improve T-cell reactivity and prevent both EBV reactivation and the associated hyperinflammation. The findings were published in the renowned journal Nature.
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Advanced disease and CD8+ TEMRA cells predict severe infections in multiple myeloma
28.02.25 | In a prospective study, staff from the Departments of Immunology and Haematology & Oncology, in collaboration with clinicians from Charité, investigated risk factors for severe infections in patients with monoclonal gammopathy of undetermined significance (MGUS) and newly diagnosed multiple myeloma (NDMM). Almost half of these patients suffered infections within the first year after diagnosis. Particularly advanced disease stages and increased concentrations of CD8+ TEMRA cells (‘terminally differentiated effector memory T cells re-expressing CD45RA’) were significantly associated with an increased risk of infection. The developed risk assessment model PREDICT-SID, which integrates clinical, laboratory and immunological parameters, was able to identify patients with a sensitivity of 93% and a specificity of 80% (AUC 0.96) who are at high risk of early severe infections and may therefore require more intensive preventive and therapeutic measures.
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A candidate reference measurement procedure for the quantification of α-synuclein in cerebrospinal fluid using an SI traceable primary calibrator and multiple reaction monitoring
29.01.25 | Neurodegenerative diseases such as Parkinson’s disease and Lewy body dementia show α-synuclein aggregation in the brain as a common key feature. Due to considerable problems with the standardisation of previous α-synuclein measurement methods, caused by the insufficient specificity and measurement accuracy of the antibodies used in conventional immunoassays, members of the Department of Immunology have developed a new reference measurement method (RMP) in an international initiative. This method, which is based on an internationally standardised (SI) calibrator and the use of liquid chromatography-tandem mass spectrometry (LC-MS/MS), enables reliable and standardised quantification of α-synuclein in cerebrospinal fluid in order to ensure comparable measurement results for patient care worldwide.
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Detection of autoantibodies against Interferon Type I in patients withautochthonous West Nile Virus encephalitis
Jan Braune, Lorenz Pechstein, Christian Meisel, Tim Meyer, Julia Melchert, Victor Max Corman, Christiana Franke, Thomas Schneider Brain, Behavior, & Immunity – Health 2025 Jul 30:48:101085 Doi: 10.1016/j.bbih.2025.101085 PMID: 40799617
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The expanding clinical utility of blood neurofilament light chain (bNfL): a multi-disciplinary diagnostic tool
Peter Körtvelyessy, Burak Arslan, Jonah Nietiet, Christoph Leithner, Petra Hühnchen, Wolfgang Böhmerle, Matthias Endres, Christoph J Ploner, Heiner Audebert, Katrin Hahn, Thomas Meyer, Andreas Lüschow, Claudia Weiss, Lisa-Valerie Biztan, Sebastian Spethmann, Adriaan J Graw, Nadine Unterwalder, Christian Meisel, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Laura Göschel Journal of the Neurological Sciences, Volume 478, 123669, November 15, 2025 Doi: 10.1016/j.jns.2025.123669 PMID: 40912227
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Soluble Urokinase Plasminogen Activator Receptor Predicts Survival and Hepatic Decompensation in Advanced Hepatocellular Carcinoma
Fabian Artusa, Sven Lamatsch, Minh Duc Phan, Burcin Özdirik, Hilmar Berger, Mara Egerer, Jana Knorr-Klocke, Janett Fischer, Rhea Veelken, Florian van Bömmel, Thomas Berg, Kai Kappert, Rudolf Tauber, Tobias Puengel, Cornelius Engelmann, Münevver Demir, Frank Tacke, Raphael Mohr Liver International 2025 Jun;45(6):e70121 Doi: 10.1111/liv.70121 PMID: 40317602
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Coordinated implementation of a conventional PCR assay to detect all Ebola and Marburg virus species in a European laboratory network
K C Heimsch, T Bleicker, T D Best, L D Presser, R Molenkamp, A J Jääskeläinen, A Milewska, J Šmahelová, C Baronti, S Pappa, I Tabain, R Cordeiro, G Marsili, K Huik, V Pinho Dos Reis, L Barzon, P Maes, C Drosten, V M Corman Journal of Clinical Virology 2025 Jun:178:105808 Doi: 10.1016/j.jcv.2025.105808 PMID: 40451100
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Serum neurofilament light chain and multimodal neuroprognostication after cardiac arrest – A retrospective cohort study
Constanze Czimmeck, Jens Nee, Carl Hinrichs, Christian Endisch, Péter Körtvélyessy, Christoph J Ploner, Christoph Leithner, Martin Kenda Resuscitation 2025 May 21:213:110650 Doi: 10.1016/j.resuscitation.2025.110650 PMID: 40409670
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Comparative evaluation of multimarker algorithms for early-stage HCC detection in multicenter prospective studies
Jinlin Hou, Thomas Berg, Arndt Vogel, Teerha Piratvisuth, Jörg Trojan, Enrico N De Toni, Masatoshi Kudo, Katarina Malinowsky, Peter Findeisen, Johannes Kolja Hegel, Wenzel Schöning, Kairat Madin, Konstantin Kroeniger, Henry Lik-Yuen Chan, Ashish Sharma; JHEP Reports 2024 Nov 8;7(2):101263, Doi: 10.1016/j.jhepr.2024.101263, PMID: 39897614
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Sysmex XN-Based Evaluation of the Diagnostic Performance of High-Fluorescent Cells From CSF as a Supportive Diagnostic Criterion in Neurological Diseases
Benedict Schwarz, Christopher Hardt, Katharina Friedrich, Monika Prpic, Anja Osterloh, Frank L Heppner, Klemens Ruprecht, Kai Kappert, Amir Jahic International Journal of Laboratory Medicine, 2025 March 20 Doi: 10.1111/ijlh.14466 PMID: 40112826
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TGFβ links EBV to multisystem inflammatory syndrome in children
Carl Christoph Goetzke, Mona Massoud, Stefan Frischbutter, Gabriela Maria Guerra, Marta Ferreira-Gomes, Frederik Heinrich, Anne Sae Lim von Stuckrad, Sebastian Wisniewski, Jan Robin Licha, Marina Bondareva, Lisa Ehlers, Samira Khaldi-Plassart, Etienne Javouhey, Sylvie Pons, Sophie Trouillet-Assant, Yasemin Ozsurekci, Yu Zhang, Maria Cecilia Poli, Valentina Discepolo, Andrea Lo Vecchio, Bengü Sahin, Murielle Verboom, Michael Hallensleben, Anja Isabelle Heuhsen, Camila Astudillo, Yazmin Espinosa, Maria Cecilia Vial Cox, Kerry Dobbs, Ottavia M. Delmonte, Gina A. Montealegre Sanchez, Mary Magliocco, Karyl Barron, Jeffrey Danielson, Lev Petrov, Nadine Unterwalder, Birgit Sawitzki, Mareen Matz, Katrin Lehmann, Alexander Gratopp, Horst von Bernuth, Lisa-Marie Burkhardt, Niklas Wiese, Lena Peter, Michael Schmueck-Henneresse, Leila Amini, Marcus Maurer, Jobst Fridolin Roehmel, Benjamin E. Gewurz, Lael M. Yonker, Mario Witkowski, Andrey Kruglov, Marcus Alexander Mall, Helen C. Su, Seza Ozen, Andreas Radbruch, Alexandre Belot, Pawel Durek, Tilmann Kallinich, Mir-Farzin Mashreghi Nature 2025 March 12 Doi: 10.1038/s41586-025-08697-6 PMID: 40074901
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Advanced disease and CD8+ TEMRA cells predict severe infections in multiple myeloma
Eva Tranter, David Busch, Clarissa Heck, Igor Wolfgang Blau, Axel Nogai, Phillip Schiele, Christian Meisel, Lars Bullinger, Marco Frentsch, Il-Kang Na Frontiers in Immunology 2025 Feb 12:16:1532645 Doi: 10.3389/fimmu.2025.1532645 PMID: 40013147
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A candidate reference measurement procedure for the quantification of α-synuclein in cerebrospinal fluid using an SI traceable primary calibrator and multiple reaction monitoring
Leran Zhang, Eva Illes-Toth, Adam Cryar, Giles Drinkwater, Lucia Di Vagno, Marie-Laure Pons, Julia Mateyka, Bryan McCullough, Eli Achtar, Cailean Clarkson, Laura Göschel, Peter Körtvélyessy, Chris Mussell, Christopher J Hopley, Agnes Flöel, Christophe Hirtz, Sylvain Lehmann , Milena Quaglia Analyst, 2024 Sep 23;149(19):4842-4850 Doi: 10.1039/d4an00634h PMID: 39041602
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