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A candidate reference measurement procedure for the quantification of α-synuclein in cerebrospinal fluid using an SI traceable primary calibrator and multiple reaction monitoring
29.01.25 | Neurodegenerative diseases such as Parkinson’s disease and Lewy body dementia show α-synuclein aggregation in the brain as a common key feature. Due to considerable problems with the standardisation of previous α-synuclein measurement methods, caused by the insufficient specificity and measurement accuracy of the antibodies used in conventional immunoassays, members of the Department of Immunology have developed a new reference measurement method (RMP) in an international initiative. This method, which is based on an internationally standardised (SI) calibrator and the use of liquid chromatography-tandem mass spectrometry (LC-MS/MS), enables reliable and standardised quantification of α-synuclein in cerebrospinal fluid in order to ensure comparable measurement results for patient care worldwide.
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A candidate reference measurement procedure for the quantification of α-synuclein in cerebrospinal fluid using an SI traceable primary calibrator and multiple reaction monitoring
Leran Zhang, Eva Illes-Toth, Adam Cryar, Giles Drinkwater, Lucia Di Vagno, Marie-Laure Pons, Julia Mateyka, Bryan McCullough, Eli Achtar, Cailean Clarkson, Laura Göschel, Peter Körtvélyessy, Chris Mussell, Christopher J Hopley, Agnes Flöel, Christophe Hirtz, Sylvain Lehmann , Milena Quaglia Analyst, 2024 Sep 23;149(19):4842-4850 Doi: 10.1039/d4an00634h PMID: 39041602
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Diagnosing recipient- vs. donor-derived posttransplant myelodysplastic neoplasm via targeted single-cell mutational profiling
Jana Ihlow, Livius Penter, Lam Giang Vuong, Philip Bischoff, Benedikt Obermayer, Alexandra Trinks, Olga Blau, Anke Behnke, Thomas Conrad, Markus Morkel, Catherine J Wu, Jörg Westermann, Lars Bullinger, Ann-Christin von Brünneck, Nils Blüthgen, David Horst, Samantha D Praktiknjo Med, 6, 1–9, 2025 Doi: 10.1016/j.medj.2024.11.001 PMID: 39644889
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A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy
Davide Bindellini, Robin Michelet, Linda B S Aulin, Johanna Melin, Uta Neumann, Oliver Blankenstein, Wilhelm Huisinga, Martin J Whitaker, Richard Ross, Charlotte Kloft Journal of Pharmacokinetics and Pharmacodynamics, 2024 December; 51(6):809-824. Doi: 10.1007/s10928-024-09934-7 PMID: 38977635
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Endocarditis associated with contamination of cardiovascular bioprostheses with Mycobacterium chelonae: a collaborative microbiological study
Judith Kikhney, Inna Friesen, Solveigh Wiesener, Laura Kursawe, Christoph Loddenkemper, Josef Zündorf, Beate Häuser, Esther P Cónsul Tejero, Dinah V Schöning, Kurosh Sarbandi, Doris Hillemann, Martin Kuhns, Miriam S Stegemann, Frieder Pfäfflin, Frank-Rainer Klefisch, Volker Düsterhöft, Sebastian Haller, Anja V Laer, Tim Eckmanns, Emmanuelle Cambau, Sarah Tschudin-Sutter, Barbara Hasse, Anette Friedrichs, Bernd Panholzer, Walter Eichinger, Petra Gastmeier, Volkmar Falk, Annette Moter Lancet Microbe, 24 October 2024:100934 doi: 10.1016/j.lanmic.2024.06.001 PMID: 39491876
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Simplified preanalytical laboratory procedures for therapeutic drug monitoring (TDM) in patients treated with high-dose methotrexate (HD-MTX) and glucarpidase
Franz L. Knörnschild, Sven Liebig, Peggy Kießling, Monika Prpic, Tehyung Kim, Ulrich Keller, Kai Kappert, Stefan Schwartz, Amir Jahic Blood Cancer Journal, 16 September 2024 doi: 10.1515/cclm-2024-052 PMID: 38997789
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Therapy-related AML: long-term outcome in a large cohort of AML-patients with intensive and non-intensive therapy
Sophia Gross, Jana Ihlow, Leonie Busack, Kacper Adamiak, Jens Schrezenmeier, Julia Jesse, Michaela Schwarz, Anne Flörcken, Lam Giang Vuong, Kathrin Rieger, Jan Krönke, Philipp le Coutre, Vivien Boldt, Ann-Christin von Brünneck, David Horst, Thomas Burmeister, Igor-Wolfgang Blau, Ulrich Keller, Lars Bullinger, Jörg Westermann Blood Cancer Journal, 16 September 2024 doi: 10.1038/s41408-024-01140-5 PMID: 39284846
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Amplification of autoimmune organ damage by NKp46-activated ILC
Stylianos-Iason Biniaris-Georgallis, Tom Aschman, Katerina Stergioula, Frauke Schreiber, Vajiheh Jafari, Anna Taranko, Tejal Karmalkar, Ana Kasapi, Tihana Lenac Rovis, Vedrana Jelencic, David A. Bejarano, Lea Fabry, Michail Papacharalampous, Irene Mattiola, Martina Molgora, Jinchao Hou, Karolin W. Hublitz, Frederik Heinrich, Gabriela Maria Guerra, Pawel Durek, Giannino Patone, Eric Lars-Helge Lindberg, Henrike Maatz, Oliver Hölsken, Gerhard Krönke, Arthur Mortha, Reinhard E. Voll, Alexander J. Clarke, Anja E. Hauser, Marco Colonna, Kevin Thurley, Andreas Schlitzer, Christoph Schneider, Efstathios G. Stamatiades, Mir-Farzin Mashreghi, Stipan Jonjic, Norbert Hübner, Andreas Diefenbach, Masatoshi Kanda & Antigoni Triantafyllopoulou Nature 2024 Aug 13 doi: 10.1038/s41586-024-07907-x PMID: 39137897
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Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19
Morgan Essex, Belén Millet Pascual-Leone, Ulrike Löber, Mathias Kuhring, Bowen Zhang, Ulrike Brüning, Raphaela Fritsche-Guenther, Marta Krzanowski, Facundo Fiocca Vernengo, Sophia Brumhard, Ivo Röwekamp, Agata Anna Bielecka, Till Robin Lesker, Emanuel Wyler, Markus Landthaler, Andrej Mantei, Christian Meisel, Sandra Caesar, Charlotte Thibeault, Victor M Corman, Lajos Marko, Norbert Suttorp, Till Strowig, Florian Kurth, Leif E Sander, Yang Li, Jennifer A Kirwan, Sofia K Forslund, Bastian Opitz NPJ Biofilms Microbiomes Aug 1, 2024 doi: 10.1038/s41522-024-00538-0 PMID: 39085233
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Clinical presentation, diagnosis, and treatment of chronic granulomatous disease
Olga Staudacher, Horst von Bernuth Frontiers in Pediatrics, June 28, 2024 doi: 10.3389/fped.2024.1384550
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Measurement uncertainty and quality assurance in the field of immunophenotyping of lymphocyte subpopulations in peripheral blood.
Nebe, Carl Thomas; Dorn-Beineke, Alexandra; Braun, Patrick; Daniel, Volker; Ilieva, Zhana; Kuling, Gudrun; Meisel, Christian; Oelschlägel, Uta; Sack, Ulrich Follow LaboratoriumsMedizin, Volume 37 (5) de Gruyter – Sep 1, 2013
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