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Publikationen

Nachfolgend sind ausgewählte Publikationen seit 2008 aufgelistet, die in Zusammenarbeit mit verschiedenen Kliniken entstanden sind:

2018

Dames C, Winek K, Beckers Y, Engel O, Meisel A, Meisel C.: Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke. J Neuroimmunol. 2018 Aug 15;321:144-149. doi: 10.1016/j.jneuroim.2018.03.005. Epub 2018 Mar 9.

Hanitsch LG, Sotzny F, Volk HD, Scheibenbogen C, Wittke K.: Serum Free Light Chains in CVID-a Marker for Differential Diagnosis. J Clin Immunol. 2018 Feb;38(2):163-165. doi: 10.1007/s10875-018-0478-y. Epub 2018 Jan 20. No abstract available.

Krüger R, Hanitsch LG, Leistner R, Schneider-Burrus S, Hoppe PA, Steinberg S, Hauck F, von Bernuth H.: Scabies, Periorbital Cellulitis and Recurrent Skin Abscesses due to Panton-Valentine Leukocidin-Positive Staphylococcus aureus Mimic Hyper IgE Syndrome in an Infant. Pediatr Infect Dis J. 2017 Dec;36(12):e347-e348. doi: 10.1097/INF.0000000000001788.

2017

Rosenfeld L, Mas Marques A, Niendorf S, Hofmann J, Gratopp A, Kühl JS, Schulte JH, von Bernuth H, Voigt S.: Life-threatening systemic rotavirus infection after vaccination in severe combined immunodeficiency (SCID). Pediatr Allergy Immunol. 2017 Dec;28(8):841-843. doi: 10.1111/pai.12771. Epub 2017 Oct 9. No abstract available.

Wahn V, von Bernuth H.: IgG subclass deficiencies in children: Facts and fiction. Pediatr Allergy Immunol. 2017 Sep;28(6):521-524. doi: 10.1111/pai.12757. Epub 2017 Aug 7. Review.

Mieves JF, Wittke K, Freitag H, Volk HD, Scheibenbogen C, Hanitsch LG.: Influenza Vaccination in Patients with Common Variable Immunodeficiency (CVID). Curr Allergy Asthma Rep. 2017 Oct 5;17(11):78. doi: 10.1007/s11882-017-0749-3. Review.

Hoffmann S, Harms H, Ulm L, Nabavi DG, Mackert BM, Schmehl I, Jungehulsing GJ, Montaner J, Bustamante A, Hermans M, Hamilton F, Göhler J, Malzahn U, Malsch C, Heuschmann PU, Meisel C, Meisel A; PREDICT Investigators.: Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia - The PREDICT study. J Cereb Blood Flow Metab. 2017 Dec;37(12):3671-3682. doi: 10.1177/0271678X16671964. Epub 2016 Oct 14.

Ulm L, Hoffmann S, Nabavi D, Hermans M, Mackert BM, Hamilton F, Schmehl I, Jungehuelsing GJ, Montaner J, Bustamante A, Katan M, Hartmann A, Ebmeyer S, Dinter C, Wiemer JC, Hertel S, Meisel C, Anker SD, Meisel A.: The Randomized Controlled STRAWINSKI Trial: Procalcitonin-Guided Antibiotic Therapy after Stroke. Front Neurol. 2017 Apr 24;8:153. doi: 10.3389/fneur.2017.00153. eCollection 2017.

Pfortmueller CA, Meisel C, Schefold JC.: Interpreting Immune Mediator Dysbalance in Sepsis. Crit Care Med. 2017 Oct;45(10):e1094-e1095. doi: 10.1097/CCM.0000000000002547. No abstract available. 

Bauer M, Krüger R, Kölsch U, Unterwalder N, Meisel C, Wahn V, von Bernuth H.: Antibiotic Prophylaxis, Immunoglobulin Substitution and Supportive Measures Prevent Infections in MECP2 Duplication Syndrome. Pediatr Infect Dis J. 2018 May;37(5):466-468. doi: 10.1097/INF.0000000000001799.

Pfortmueller CA, Meisel C, Fux M, Schefold JC.: Assessment of immune organ dysfunction in critical illness: utility of innate immune response markers. Intensive Care Med Exp. 2017 Oct 23;5(1):49. doi: 10.1186/s40635-017-0163-0. Review.

2016

Erdur H, Scholz V, Streitz M, Hammer M, Meisel C, Schönemann C, Wandinger KP, Rosche B.: EBNA1 antigen-specific CD8+ T cells in cerebrospinal fluid of patients with multiple sclerosis. J Neuroimmunol. 2016 May 15;294:14-7. doi: 10.1016/j.jneuroim.2016.03.010. Epub 2016 Mar 19.

Klehmet J, Hoffmann S, Walter G, Meisel C, Meisel A.: Stroke induces specific alteration of T memory compartment controlling auto-reactive CNS antigen-specific T cell responses. J Neurol Sci. 2016 Sep 15;368:77-83. doi: 10.1016/j.jns.2016.06.039. Epub 2016 Jun 17.

Hagl B, Heinz V, Schlesinger A, Spielberger BD, Sawalle-Belohradsky J, Senn-Rauh M, Magg T, Boos AC, Hönig M, Schwarz K, Dückers G, von Bernuth H, Pache C, Karitnig-Weiss C, Belohradsky BH, Frank J, Niehues T, Wahn V, Albert MH, Wollenberg A, Jansson AF, Renner ED.: Key findings to expedite the diagnosis of hyper-IgE syndromes in infants and young children. Pediatr Allergy Immunol. 2016 Mar;27(2):177-84. doi: 10.1111/pai.12512. Epub 2016 Jan 26. 

Hanitsch LG, Löbel M, Mieves JF, Bauer S, Babel N, Schweiger B, Wittke K, Grabowski P, Volk HD, Scheibenbogen C.: Cellular and humoral influenza-specific immune response upon vaccination in patients with common variable immunodeficiency and unclassified antibody deficiency. Vaccine. 2016 May 5;34(21):2417-2423. doi: 10.1016/j.vaccine.2016.03.091. Epub 2016 Apr 5.

2015

Hanitsch LG1, Löbel M, Müller-Redetzky H, Schürmann M, Suttorp N, Unterwalder N, Mönnich U, Meisel C, Wittke K, Volk HD, Scheibenbogen C, Kölsch U. Late-Onset Disseminated Mycobacterium avium intracellulare Complex Infection (MAC), Cerebral Toxoplasmosis and Salmonella Sepsis in a German Caucasian Patient with Unusual Anti-Interferon-Gamma IgG1 Autoantibodies. J Clin Immunol. 2015 Apr 15. [Epub ahead of print] PMID: 25875701

Kallinich T, Kölsch U, Lieber M, Unterwalder N, Spors B, Lorenz M, Schwarz K, Meisel C, von Bernuth H. In patients with defects in Toll-like and Interleukin-1 receptor (TIR)-dependent signalling septic arthritis may present like Juvenile Idiopathic Arthritis. Pediatr Allergy Immunol. 2015 Apr 9. doi: 10.1111/pai.12373. [Epub ahead of print] PMID: 25865658

Bauer M, Kölsch U, Krüger R, Unterwalder N, Hameister K, Kaiser FM, Vignoli A, Rossi R, Botella MP, Budisteanu M, Rosello M, Orellana C, Tejada MI, Papuc SM, Patat O, Julia S, Touraine R, Gomes T, Wenner K, Xu X, Afenjar A, Toutain A, Philip N, Jezela-Stanek A, Gortner L, Martinez F, Echenne B, Wahn V, Meisel C, Wieczorek D, El-Chehadeh S, Van Esch H, von Bernuth H. Infectious and Immunologic Phenotype of MECP2 Duplication Syndrome.J Clin Immunol. 2015 Feb;35(2):168-81. doi: 10.1007/s10875-015-0129-5. Epub 2015 Feb 27. PMID: 25721700

2014

Schefold JC, Porz L, Uebe B, Poehlmann H, von Haehling S, Jung A, Unterwalder N, Meisel C: Diminished HLA-DR expression on monocyte and dendritic cell subsets indicating impairment of cellular immunity in pre-term neonates: a prospective observational analysis.J Perinat Med. 2014 Oct 25. pii: /j/jpme.ahead-of-print/jpm-2014-0226/jpm-2014-0226.xml. doi: 10.1515/jpm-2014-0226. PMID: 25418981

von Bernuth H, Ravindran E, Du H, Fröhler S, Strehl K, Krämer N, Issa-Jahns L, Amulic B, Ninnemann O, Xiao MS, Eirich K, Kölsch U, Hauptmann K, John R, Schindler D, Wahn V, Chen W, Kaindl AM: Combined immunodeficiency develops with age in Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2). Orphanet J Rare Dis. 2014 Oct 21;9(1):116. doi: 10.1186/s13023-014-0116-6 PMID: 25330735

Klehmet J, Goehler J, Ulm L, Kohler S, Meisel C, Meisel A, Harms H: Effective treatment with intravenous immunoglobulins reduces autoreactive T-cell response in patients with CIDP.J Neurol Neurosurg Psychiatry. 2014 Jul 29. pii: jnnp-2014-307708. doi: 10.1136/jnnp-2014-307708. Epub 2014 Jul 29 PMID: 25074566

Schöndorf D, von Bernuth H, Simon A, Schneider G, Kölsch U, Schwarz K, Meier CM, Groe-Onnebrink J, Gortner L, Rohrer TR: Liver abscess complicated by diaphragm perforation and pleural empyema leads to the discovery of interleukin-1 receptor-associated kinase 4 deficiency.Pediatr Infect Dis J. 2014 Jul;33(7):767-9. doi: 10.1097/INF.0000000000000277. PMID: 24717963

Loebel M, Strohschein K, Giannini C, Koelsch U, Bauer S, Doebis C, Thomas S, Unterwalder N, von Baehr V, Reinke P, Knops M, Hanitsch LG, Meisel C, Volk HD, Scheibenbogen C: Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome.PLoS One. 2014 Jan 15;9(1):e85387. doi: 10.1371/journal.pone.0085387. eCollection 2014. PMID: 24454857

Howard MF, Murakami Y, Pagnamenta AT, Daumer-Haas C, Fischer B, Hecht J, Keays DA, Knight SJ, Kölsch U, Krüger U, Leiz S, Maeda Y, Mitchell D, Mundlos S, Phillips JA 3rd, Robinson PN, Kini U, Taylor JC, Horn D, Kinoshita T, Krawitz PM.: Mutations in PGAP3 impair GPI-anchor maturation, causing a subtype of hyperphosphatasia with mental retardation. Am J Hum Genet. 2014 Feb 6;94(2):278-87.

Sassi A, Lazaroski S, Wu G, Haslam SM, Fliegauf M, Mellouli F, Patiroglu T, Unal E, Ozdemir MA, Jouhadi Z, Khadir K, Ben-Khemis L, Ben-Ali M, Ben-Mustapha I, Pfeifer D, Jakob T, Khemiri M, Asplund CA, Gustafsson MO, Lundin KE, Falk-Sörqvist E, Moens LN, Gungor HE, Engelhardt KR, Dziadzio M, Stauss H, Fleckenstein B, Meier R, Prayitno K, Maul-Pavicic A, Schaffer S, Rakhmanov M, Henneke P, Kraus H, Eibel H, Kölsch U, Nadifi S, Nilsson M, Bejaoui M, Schäffer AA, Edvard Smith CI, Dell A, Barbouche MR, Grimbacher B: Hypomorphic, homozygous mutations in Phosphoglucomutase 3 impair immunity and increase serum IgE levels. J All Clin Immunol - J Allergy Clin Immunol. 2014 May;133(5):1410-9.

2013

Bretschneider I, Clemente MJ, Meisel C, Guerreiro M, Streitz M, Hopfenmüller W, Maciejewski JP, Wlodarski MW, Volk HD: Discrimination of T-cell subsets and T-cell receptor repertoire distribution.Immunol Res. 2013 Nov 23. PMID: 24272857

Streitz M, Miloud T, Kapinsky M, Reed MR, Magari R, Geissler EK, Hutchinson JA, Vogt K, Schlickeiser S, Kverneland AH, Meisel C, Volk HD, Sawitzki B: Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study.Transplant Res. 2013 Oct 25;2(1):17. [Epub ahead of print] PMID:24160259

Nebe, Carl Thomas; Dorn-Beineke, Alexandra; Braun, Patrick; Daniel, Volker; Ilieva, Zhana; Kuling, Gudrun; Meisel, Christian; Oelschlägel, Uta; Sack, Ulrich: Messunsicherheit und Qualitätssicherung im Bereich der Immunphänotypisierung der Lymphozytensubpopulationen im peripheren Blut.
Follow LaboratoriumsMedizin, Volume 37 (5) de Gruyter – Sep 1, 2013

Gerlach UA, Vogt K, Schlickeiser S, Meisel C, Streitz M, Kunkel D, Appelt C, Ahrlich S, Lachmann N, Neuhaus P, Pascher A, Sawitzki B: Elevation of CD4+ differentiated memory T cells is associated with acute cellular and antibody-mediated rejection after liver transplantation. Transplantation. 2013 Aug 27;96(4):e33. PMID:23619734

Leisering J, Renner E.D, von Bernuth H, Wahn V, Rossi R: Konnatale Pneumonie und pustulöse Hautveränderungen bei einem männlichen Säugling. Monatsschrift Kinderheilkunde 8. 2013, Juni

Reinke S, Geissler S, Taylor WR, Schmidt-Bleek K, Juelke K, Schwachmeyer V, Dahne M, Hartwig T, Akyüz L, Meisel C, Unterwalder N, Singh NB, Reinke P, Haas NP, Volk HD, Duda GN:Terminally differentiated CD8⁺ T cells negatively affect bone regeneration in humans. Sci Transl Med. 2013 May 29;5(187):187er4. PMID:23515078

Schürmann M, Schürmann D, Schindler R, Meisel C, Liman P, Kruse J, Enghard P, König J, Schmidt D, Reinke P, Nickel P: Impaired thymic function and CD4+ T lymphopenia, but not mannose-binding lectin deficiency, are risk factors for Pneumocystis jirovecii pneumonia in kidney transplant recipients. Transpl Immunol. 2013 Jun;28(4):159-63. doi: 10.1016/j.trim.2013.05.003. Epub 2013 May 15. PMID:23684946

Andres O, Strehl K, Kölsch U, Kunzmann S, Lebrun AH, Stroh T, Schwarz K, Morbach H, von Bernuth H, Liese J: Even in Pneumococcal Sepsis CD62L Shedding on Granulocytes Proves to be a Reliable Functional Test for the Diagnosis of Interleukin-1 Receptor Associated Kinase 4 Deficiency. Pediatr Infect Dis J. 2013 Mar 27. [Epub ahead of print] PMID:23538514

2012

Bernuth von H, Picard C, Puel A, Casanova J-L: Expermental and natural infections in MyD88- and IRAK-4-deficient mice and humans. Eur. J. Immunol. 2012. 42: 3126-3135. http://onlinelibrary.wiley.com/doi/10.1002/eji.201242683/abstract

Yang CA, Raftery MJ, Hamann L, Guerreiro M, Grütz G, Haas D, Unterwalder N, Schönrich G, Schumann RR, Volk HD, Scheibenbogen C: Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis, Hum Immunol. 2012 Aug 73(8):844-51. doi: 10.1016/j.humimm.2012.04.008. Epub 2012 Apr 23. PMID:22537752

Von Haehling S, Schefold JC, Jankowska EA, Springer J, Vazir A, Kalra PR, Sandek A, Fauler G, Stojakovic T, Trauner M, Ponikowski P, Volk HD, Doehner W, Coats AJ, Poole-Wilson PA, Anker SD: Ursodeoxycholic acid in patients with chronic heart failure: a double-blind, randomized, placebo-controlled, crossover trial, J Am Coll Cardiol. 2012 Feb 7;59(6):585-92. PMID:22300693

Haeusler, K.G., W.U. Schmidt, F. Foehring, C. Meisel, C. Guenther, P. Brunecker, C. Kunze, T. Helms, U. Dirnagl, H.D. Volk, and A. Villringer: Immune responses after acute ischemic stroke or myocardial infarction, Int J Cardiol, 2012. 155(3): p. 372-7. PMID:21078527

2011

Streitz, M., S. Fuhrmann, F. Powell, A. Quassem, L. Nomura, H. Maecker, P. Martus, H.D. Volk, and F. Kern: Tuberculin-specific T cells are reduced in active pulmonary tuberculosis compared to LTBI or status post BCG vaccination, J Infect Dis, 2011. 203(3): p. 378-82. PMID:21186260

Sarrafzadeh, A., F. Schlenk, A. Meisel, J. Dreier, P. Vajkoczy, and C. Meisel: Immunodepression after aneurysmal subarachnoid hemorrhage, Stroke, 2011. 42(1): p. 53-8. PMID:21088239

Meisel, C. and A. Meisel, N Engl: Suppressing immunosuppression after stroke, J Med, 2011. 365(22): p. 2134-6. PMID:22129259

Kuhl, J.S., K. Schwarz, A. Munch, M. Schmugge, A. Pekrun, C. Meisel, V. Wahn, W. Ebell, and H. von Bernuth: Hyperbilirubinemia and rapid fatal hepatic failure in severe combined immunodeficiency caused by adenosine deaminase deficiency (ADA-SCID), Klin Padiatr, 2011. 223(2): p. 85-9. PMID:21271505 

Heine, G., G. Drozdenko, A. Lahl, N. Unterwalder, H. Mei, H.D. Volk, T. Dorner, A. Radbruch and M. Worm: Efficient tetanus toxoid immunization on vitamin D supplementation, Eur J Clin Nutr, 2011. 65(3): p. 329-34. PMID:21224870

Harms, H., P. Reimnitz, G. Bohner, T. Werich, R. Klingebiel, C. Meisel, and A. Meisel: Influence of stroke localization on autonomic activation, immunodepression, and post-stroke infection, Cerebrovasc Dis, 2011. 32(6): p. 552-60. PMID:22104620

Hall, M.W., N.L. Knatz, C. Vetterly, S. Tomarello, M.D. Wewers, H.D. Volk, and J.A. Carcillo: Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome, Intensive Care Med, 2011. 37(3): p. 525-32. PMID:21153402 

Farmand, S., U. Baumann, H. von Bernuth, M. Borte, E. Foerster-Waldl, K. Franke, P. Habermehl, P. Kapaun, G. Klock, J. Liese, R. Marks, R. Muller, T. Nebe, T. Niehues, V. Schuster, K. Warnatz, T. Witte, S. Ehl, and I. Schulze: Interdisciplinary AWMF guideline for the diagnostics of primary immunodeficiency, Klin Padiatr, 2011. 223(6): p. 378-85. PMID:22052638

2010

Unterwalder, N., C. Meisel, K. Savvatis, B. Hammoud, C. Fotopoulou, H.D. Volk, P. Reinke, and J.C. Schefold: High-mobility group box-1 protein serum levels do not reflect monocytic function in patients with sepsis-induced immunosuppression, Mediators Inflamm, 2010. 2010: p. 745724. PMID:20652004 

Picard, C., H. von Bernuth, et al.: Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency, Medicine (Baltimore), 2010. 89(6): p. 403-25. PMID:21057262 

Monneret, G., F. Venet, C. Meisel, and J.C. Schefold: Assessment of monocytic HLA-DR expression in ICU patients: analytical issues for multicentric flow cytometry studies, Crit Care, 2010. 14(4): p. 432. PMID:20670390

 Krawitz PM, Schweiger MR, Rödelsperger C, Marcelis C, Kölsch U, Meisel C, Stephani F, Kinoshita T, Murakami Y, Bauer S, Isau M, Fischer A, Dahl A, Kerick M, Hecht J, Köhler S, Jäger M, Grünhagen J, de Condor BJ, Doelken S, Brunner HG, Meinecke P, Passarge E, Thompson MD, Cole DE, Horn D, Roscioli T, Mundlos S, Robinson: Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrom. Nat Genet. 2010 Oct; 42(10):827-9.

2009

Rossberg, S., K. Schwarz, C. Meisel, S. Holzhauer, J. Kuhl, W. Ebell, V. Wahn, and H. von Bernuth: Delayed onset of (severe) combined immunodeficiency (S)CID (T-B+NK+): complete IL-7 receptor deficiency in a 22 months old girl, Klin Padiatr, 2009. 221(6): p. 339-43. PMID:19890784

Poehlmann, H., J.C. Schefold, H. Zuckermann-Becker, H.D. Volk, and C. Meisel: Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis, Crit Care, 2009. 13(4): p. R119. PMID:19604380

Meisel, C., J.C. Schefold, R. Pschowski, T. Baumann, K. Hetzger, J. Gregor, S. Weber-Carstens, D. Hasper, D. Keh, H. Zuckermann, P. Reinke, and H.D. Volk: Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial, Am J Respir Crit Care Med, 2009. 180(7): p. 640-8. PMID:19590022

Hoeflich, C., N. Unterwalder, S. Schuett, K. Schmolke, O. Boenisch, M. Hammer, R. Scheufele, D. Michael, H.D. Volk, C. Scheibenbogen, V. von Baehr, and C. Meisel: Clinical manifestation of mannose-binding lectin deficiency in adults independent of concomitant immunodeficiency, Hum Immunol, 2009. 70(10): p. 809-12. PMID:19580835 

2008

Von Bernuth, H., C. Picard, Z. Jin, et al.: Pyogenic bacterial infections in humans with MyD88 deficiency, Science, 2008. 321(5889): p. 691-6. PMID:18669862

Koelsch U, Schraven B, Simeoni L; SIT and TRIM determine T-cell fate in the thymus; J. Immunology; Journal of Immunology, 2008, 181: 5930–5939