Lupe
Reagenzglas

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Leistungsverzeichnis

Publikationen

2014

G.Baldenhofer; S.Spethmann, M.Laule, B.Eilers, W.Sanad, H.Dreger, G.Baumann, K.Stangl, V.Stangl, F.Knebel. Core 6. Catheter-Based and Surgical Interventions. Session Title: Transcatheter Aortic Valve. Replacement: Biomarkers and Imaging; Abstract 12803: Galectin-3 is a Prognostic Biomarker for Patients After Transcatheter Aortic Valve Implantation. 2014; 130: A12803

Baldenhofer G, Zhang K, Spethmann S, Laule M, Eilers B, Leonhardt F, Sanad W, Dreger H, Sander M, Grubitzsch H, Baumann G, Stangl K, Stangl V, Knebel F.
Galectin-3 predicts short- and long-term outcome in patients undergoing
transcatheter aortic valve implantation (TAVI). Int J Cardiol. 2014 Oct
20;177(3):912-917. PMID: 25456698

Singer BB, Opp L, Heinrich A, Schreiber F, Binding-Liermann R, Berrocal-Almanza LC, Heyl KA, Müller MM, Weimann A, Zweigner J, Slevogt H. Soluble CEACAM8 Interacts with CEACAM1 Inhibiting TLR2-Triggered Immune Responses. PLoS One. 2014 Apr 17. PMID: 24743304

Otto C, Hofmann J, Finke C, Zimmermann M, Ruprecht K. The fraction of varicella zoster virus-specific antibodies among all intrathecally-produced antibodies discriminates between patients with varicella zoster virus reactivation and multiple sclerosis. Fluids Barriers CNS. 2014 Feb 12. PMID: 24517462

Weiss D, Neuner B, Gorzelniak K, Bremer A, Rudack C, Walter M. Platelet glycoproteins and fibrinogen in recovery from idiopathic sudden hearing loss. PLoS One. 2014 Jan 23. PMID: 24466284   

2013

Kannenberg F,  Gorzelniak K, Jäger K, Fobker M, Rust S, Repa J, Roth M, Björkhem I, Walter M.Characterization of cholesterol homeostasis in telomerase-immortalized Tangier disease fibroblasts reveals marked phenotype variability. J Biol Chem. 2013 Dec 27. PMID: 24196952

Nachtigall I, Tamarkin A, Tafelski S, Weimann A, Rothbart A, Heim S, Wernecke KD, Spies C: Polymorphisms of the toll-like receptor 2 and 4 genes are associated with faster progression and a more severe course of sepsis in critically ill patients. J Int Med Res. 2013 Dec 23. [Epub ahead of print] PMID: 24366499

T. Grobosch, N. Felgenhauer, T. Binscheck: Two non-fatal cases of concealed self-poisonings with aconitine. 51th Annual meeting of the International Association of Forensic Toxicologists (TIAFT), Funchal, Portugal, 02.-06.09.2013.

L. Mut, T. Grobosch, T. Binscheck, F. Eyer, W. Frenzel: Quantification of Irbesartan, Losartan and Olmesartan in Human Plasma  by HPLC-DAD using a Novel On-line Strong Anion Exchanger - A case report of acute self-poisoning with irbesartan. 51th Annual meeting of the International Association of Forensic Toxicologists (TIAFT), Funchal, Portugal, 02.-06.09.2013.

S.M. Fiebiger, H. Bros, T. Grobosch, A. Janssen, C. Chanvillard, F. Paul, J. Dörr, J.M. Millward, C. Infante-Duarte: The antioxidant idebenone fails to prevent or attenuate chronic experimental autoimmune encephalomyelitis in the mouse. J Neuroimmunol. 2013 Sep 15;262(1-2):66-71. doi: 10.1016/j.jneuroim.2013.07.002. Epub 2013 Jul 18. PMID: 23871488

2012

T. Grobosch, B. Schwarze, N. Felgenhauer, B. Riesselmann, S. Roscher, T. Binscheck. Eight cases of fatal and non-fatal poisoning with Taxus baccata. Forensic Sci Int. Volume 227, Issues 1–3, 10 April 2013, Pages 118–126.Forensic Sci Int. 2013 Apr 10;227(1-3):118-26. doi: 10.1016/j.forsciint.2012.11.014. Epub 2012 Dec 21. PMID: 23265441

M.S. Rubelt, S. Amasheh, T. Grobosch, C. Stein: Liquid Chromatography-Tandem Mass Spectrometry for Analysis of Intestinal Permeability of Loperamide in Physiological Buffer. PLoS One. 2012;7(11):e48502. doi: 10.1371/journal.pone.0048502. Epub 2012 Nov 8. PMID: 23144895

T. Grobosch. The poisoned patient. Modern methods in clinical and analytical toxicology. Biochemia Medica 2012; 22(3): A41.

T. Grobosch, T. Binscheck. Cannabinomimetics - A new challenge in routine clinical toxicology. A case report of an intoxication with JWH-018. Biochemia Medica 2012; 22(3): A191.

L. Mut, T. Grobosch, T. Binscheck, W. Frenzel. Identification of acidic compounds in acute Intoxications by on-line SPE-HPLC-DAD. Biochemia Medica 2012; 22(3): A192

T. Grobosch, T. Binscheck. Rapid identification of vitamin K antagonists in human plasma by XLC-QqTOF: A report of poisonings with brodifacoum, difenacoum, flocoumafen and phenprocoumon. 50th Annual meeting of the International Association of Forensic Toxicologists (TIAFT), Hamamatsu, Japan, 03.06-08.06.2012.
L. Mut, T. Grobosch, T. Binscheck, W. Frenzel. Application of an On-line Extraction Liquid Chromatography Photodiode-Array Detection Procedure for Screening and Quantification of Xenobiotics in Human Plasma as Part of Routine Systematic Toxicological Analysis. 50th Annual meeting of the International Association of Forensic Toxicologists (TIAFT), Hamamatsu, Japan, 03.06-08.06.2012.

T. Grobosch, B. Schwarze, D. Stoecklein  T. Binscheck: Fatal poisoning with Taxus baccata: Quantification of paclitaxel, 10-deacetyltaxol, baccatin III, 10-deacetylbaccatin III and cephalomannine (taxol B) and of 3,5-dimethoxyphenol in body fluids by LC-MS/MS. J Anal Toxicol. 2012 Jan;36(1):36-43. PMID: 22290751

2011

E. Frisch, M. Kaup, K. Egerer, A. Weimann, R. Tauber, M. Berger and V. Blanchard. Profiling of Endo H-released serum N-glycans using CE-LIF and MALDI-TOF-MS--application to rheumatoid arthritis. Electrophoresis 2011, Dec; 32 (24), 3510-3515. PMID: 22180205

M. Zimmermann, K. Ruprecht, F. Kainzinger, F. L. Heppner and A. Weimann (2011). Automated vs. manual cerebrospinal fluid cell counts: a work and cost analysis comparing the Sysmex XE-5000 and the Fuchs–Rosenthal manual counting chamber. Int Jnl Lab Hem; epub ahead of print. PMID: 21668655

T. Grobosch, L. Mut, T. Binscheck. Einfache Probenvorbereitung, automatische Analyse. Eine neue  Methode auf der Basis von LC und Diodenarraydetektion identifiziert im toxikologischen Labor automatisch Fremdstoffe in Blut- und Urinproben. Nachrichten aus der Chemie 59 (2011) 1171-1173.

T. Grobosch, B. Schwarze, D. Stoecklein, T. Binscheck. Fatal poisoning with Taxus baccata: Quantification of paclitaxel, 10-deacetyltaxol, baccatin III, 10-deacetylbaccatin III and cephalomannine (taxol B) and of 3,5-dimethoxyphenol in body fluids by LC-MS/MS. J. Anal. Toxicol. In press. BBGes (T. Grobosch), Spark Holland. PMID: 22290751

BBGes and Spark Holland develop Toxicological Screening system based on on-line SPE-LC with accurate-mass MS/MS detection.press release (in press) M. Heydt,  S. Amasheh, T. Grobosch,  C. Stein. Liquid Chromatography-Tandem Mass Spectrometry for Analysis of Intestinal Permeability of Opioids in Physiological Buffer. Eingereicht in Analytical and Bioanalytical Chemistry. PMID: 23144895

L. Mut, T. Grobosch, T. Binscheck. Automatische Quantifizierung von Doxylamin und Diphenhydramin im Plasma. Shimadzu News 1 (2011) 14-16.

L. Mut, T. Grobosch, T. Binscheck. Automated quantification of doxylamine und diphenhydramine in human plasma. Shimadzu News 1 (2011) 14-16.

M. Heydt, S. Amasheh, T. Grobosch, L.J. Lang, M. Fromm, C. Stein.
Paracellular transport of a hydrophilic opioid receptor agonist is increased by chitosan. 90th Annual Meeting of the German Physiological Society, March 26 to March 29, 2011, in Regensburg

W. Weinmann, M. Hutter, S. Dresen, C.Köhler, T.Grobosch, S. Lanz, S.König. Modified Multi Target Screening (MTS) with QTrap 3200 and methanol as eluent with Luna PFP column. Proceedings  XVII. Symposium der GTFCh (Mosbach 14.-16.04.2011).
 
C. Köhler, T. Grobosch, T. Binscheck, P. Surmann: Development of a systematic toxicological screening method using an automated on-line SPE-LC-QqTOF System (XLC-QqTOF). Proceedings XVII. Symposium der GTFCh (Mosbach 14.-16.04.2011).

L. Mut, T. Grobosch, T. Binscheck. Automated Quantification of Doxylamine and Diphenhydramine in Human Plasma using on-line extraction-HPLC-DAD (TOX.I.S.). Proceedings XVII. Symposium der GTFCh (Mosbach 14.-16.04.2011).
 
L. Mut, T. Grobosch, T. Binscheck. Automatische Quantifizierung von Doxylamin und Diphen-hydramin im Plasma mittels TOX.I.S. Eine neue Methode zur automatischen und quantitativen Bestimmung von Medikamenten in humanem Plasma. GIT 02/2011 116-119.

AB SCIEX, GENEBIO, BBGes (T. Grobosch).
Press release: AB SCIEX and GeneBio Team Up to Improve Interactive Library Searching for Mass Spectrometry - SmileMS to increase functionality for small molecule identification on LC/MS/MS systems. http://www.ionsource.com/press/gene_bio_9-29-10.htm

Pierre-Alain Binz, Christoph Köhler, Roman Mylonas, Alexandre Masselot, Nicolas Budin, Thomas Grobosch, Torsten Binscheck.
LC-MSMS library search approach for toxicological screening: Efficiently use of high mass precision.
ASMS Conference on Mass Spectrometry and Allied Topics June 5 - 9, 2011, Denver, USA.