• Value of hemophagocytosis in the diagnosis of hemophagocytic lymphohistiocytosis in critically ill patients

    Peter Nyvlt, Friederike S Schuster, Jana Ihlow, Patrick Heeren, Claudia Spies, Josephine Hiesgen, Thomas Schenk, Ann-Christin von Brünneck, Jörg Westermann, Frank M Brunkhorst, Paul La Rosée, Gritta Janka, Cornelia Lachmann, Gunnar Lachmann European Journal of Haematology 2024 Feb 18 doi: 10.1111/ejh.14185 PMID: 38368850

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    Florian Loch, Carsten Kamphues, Peter Menzel, Rolf Schwarzer, Katharina Beyer, Christian Schineis Frontiers in Cellular and Infection Microbiology, 12. Januar 2024 doi: 10.3389/fcimb.2023.1324668 PMID: 38282618

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  • Fettstoffwechselstörungen und vaskuläres Risiko

    Prof. Dr. med. Michael Walter

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  • Correlation of SARS-CoV-2 RNA and nucleocapsid concentrations in samples used in INSTAND external quality assessment schemes

    Esmeralda Valiente, Samreen Falak, Andreas Kummrow, Martin Kammel, Victor M Corman, Rainer Macdonald, Heinz Zeichhardt BMC Res Notes. 2023 Sep 11;16(1):210 doi: 10.1186/s13104-023-06497-7 PMID: 37697348

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  • In vitro studies on the dependence of drug deposition in dentin on drug concentration, contact time, and the physicochemical properties of the drugs

    Miriam Klima, Volker Auwärter, Markus J. Altenburger und Merja A. Neukamm; Toxicokinetics and Metabolism, 2023 Aug 16;10:1194754; doi: 10.1007/s00204-023-03573-6; PMID: 37587384

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  • Fighting Post-COVID and ME/CFS – development of curative therapies

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  • Risk Factors for Hepatitis E Virus Infection and Eating Habits in Kidney Transplant Recipients

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  • Fatal congenital copper transport defect caused by a homozygous likely pathogenic variant of SLC31A1

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  • HE4 as a serum biomarker for the diagnosis of pelvic masses: a prospective, multicenter study in 965 patients

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  • ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery

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  • Neurofilament light-chain response during therapy with antisense oligonucleotide tofersen in SOD1-related ALS: Treatment experience in clinical practice

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  • Advanced sequencing approaches detected insertions of viral and human origin in the viral genome of chronic hepatitis E virus patients.

    Papp CP, Biedermann P, Harms D, Wang B, Kebelmann M, Choi M, Helmuth J, Corman VM, Thürmer A, Altmann B, Klink P, Hofmann J, Bock CT. Scientific Reports 2022 Feb 2;12(1):1720 DOI: 10.1038/s41598-022-05706-w PMC: PMC8811047

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  • Novel noncanonical splice site variant causes mild CHD7-related disorder with variable intrafamilial expressivity

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  • The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation.

    Reinhold D, Farztdinov V, Yan Y, Meisel C, Sadlowski H, Kühn J, Perschel FH, Endres M, Düzel E, Vielhaber S, Guttek K, Goihl A, Venø M, Teegen B, Stöcker W, Stubbemann P, Kurth F, Sander LE, Ralser M, Otto C, Streit S, Jarius S, Ruprecht K, Radbruch H, Kjems J, Mülleder M, Heppner F, Körtvelyessy P. Journal of Neuroinflammation 2023 Feb 9; 20(1):30 DOI: 10.1186/s12974-023-02711-2 PMID: 36759861

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  • Serum neurofilament light chain in myasthenia gravis subgroups: An exploratory cohort and case-Control study 

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  • Persistent but atypical germinal center reaction among 3rd SARS-CoV-2 vaccination after rituximab exposure 

    Ana-Luisa Stefanski, Hector Rincon-Arevalo, Eva Schrezenmeier, Kirsten Karberg, Franziska Szelinski, Jacob Ritter, Yidan Chen, Christian Meisel, Bernd Jahrsdörfer, Carolin Ludwig, Hubert Schrezenmeier, Andreia C Lino, Thomas Dörner Frontiers in Immunology, 2022 August, Vol 13 DOI: 10.3389/fimmu.2022.943476 PMID: 36032111

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  • IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NF-κB-Induced Inflammation

    Ilona Gottschalk, Uwe Kölsch, Dimitrios L Wagner, Jonas Kath, Stefania Martini, Renate Krüger, Anne Puel, Jean-Laurent Casanova, Aleksandra Jezela-Stanek, Rainer Rossi, Salima El Chehadeh, Hilde Van Esch, Horst von Bernuth Journal of Clinical Immunology, 2022 Nov 2 DOI: 10.1007/s10875-022-01390-7 PMID: 36319802

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  • Non-redundant functions of group 2 innate lymphoid cells

    Katja J. Jarick, Patrycja M. Topczewska, Manuel O. Jakob, Hiroshi Yano, Mohammad Arifuzzaman, Xuemei Gao, Sotiria Boulekou, Vladislava Stokic-Trtica, Pierre S. Leclère, Alexandra Preußer, Zoe A. Rompe, Anton Stamm, Amy M. Tsou, Coco Chu, Frederik R. Heinrich, Gabriela M. Guerra, Pawel Durek, Andranik Ivanov, Dieter Beule, Sofia Helfrich, Claudia U. Duerr, Anja A. Kühl, Christina Stehle, Chiara Romagnani, Mir-Farzin Mashreghi, Andreas Diefenbach, David Artis & Christoph S. N. Klose; Nature volume 611, pages 794–800 (2022) DOI: 10.1038/s41586-022-05395-5 PMID: 36323785

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  • Delta-He, Ret-He and a New Diagnostic Plot for Differential Diagnosis and Therapy Monitoring of Patients Suffering from Various Disease-Specific Types of Anemia

    Andreas Weimann, Malte Cremer, Pablo Hernáiz-Driever, Mathias Zimmermann; Clin. Lab. 2016;62(4):667-77 DOI: 10.7754/clin.lab.2015.150830 PMID: 27215087

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  • Real-life experiences with bulevirtide for the treatment of hepatitis delta-48 weeks data from a German centre

    Zöllner C, Hofmann J, Lutz K, Tacke F, Demir M. Real-life experiences with bulevirtide for the treatment of hepatitis delta-48 weeks data from a German centre. Liver Int. 2022 Nov;42(11):2403-2407. doi: 10.1111

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  • Identification of anti-microbial peptides and traces of microbial DNA in infrainfundibular compartments of human scalp terminal hair follicles

    Katarzyna Polak-Witka, Andria Constantinou, Rolf Schwarzer, Johannes Helmuth, Alexandra Wiessner, Sabrina Hadam, Varvara Kanti, Fiorenza Rancan, Annette Andruck, Claudia Richter, Annette Moter, Anke Edelmann, Lidia Rudnicka, Ulrike Blume-Peytavi & Annika Vogt; Eur J Dermatol 31, 22–31 (2021) DOI: 10.1684/ejd.2020.3948 PMID: 33586659

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  • Exploring Dried Blood Spot Cortisol Concentrations as an Alternative for Monitoring Pediatric Adrenal Insufficiency Patients: A Model-Based Analysis

    Viktoria Stachanow, Uta Neumann, Oliver Blankenstein, Davide Bindellini, Johanna Melin, Richard Ross, Martin J Whitaker, Wilhelm Huisinga, Robin Michelet, Charlotte Kloft; Frontiers in Pharmacology, 2022 Mar 17; DOI: 10.3389/fphar.2022.819590; PMCID: PMC8968419; PMID: 35370666

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  • Viral infections in hospitalized children in Germany during the COVID-19 pandemic: Association with non-pharmaceutical interventions

    Nicolas Terliesner, Nadine Unterwalder, Anke Edelmann, Victor Corman, Andreas Knaust, Leonard Rosenfeld, Alexander Gratopp, Hannelore Ringe, Luise Martin, Horst von Bernuth, Marcus A Mall, Tilmann Kallinich; Frontiers in Pediatrics, 2022; 10: 935483.; DOI: 10.3389/fped.2022.935483, PMCID: PMC9403271

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  • A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity

    C Kedor, H Freitag, L Meyer-Arndt, K Wittke, L G Hanitsch, T Zoller, F Steinbeis, M Haffke , G Rudolf, B Heidecker, T Bobbert, J Spranger, H D Volk, C Skurk, F Konietschke, F Paul, U Behrends, J Bellmann-Strobl, C Scheibenbogen; Nature Communications, 2022 Aug 30;13(1):5104. DOI: 10.1038/s41467-022-32507-6 PMCID: PMC9426365

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  • Peroxisomal very long-chain fatty acid transport is targeted by herpesviruses and the antiviral host response

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  • Role of Cell Adhesion Molecules for Prognosis of Disease Development of Patients With and Without COVID-19 in the Emergency Department

    Wolfgang Bauer, Jannis Ulke, Noa Galtung, Leonore Claudia Strasser-Marsik, Nick Neuwinger, Rudolf Tauber, Rajan Somasundaram, Kai Kappert, Role of Cell Adhesion Molecules for Prognosis of Disease Development of Patients With and Without COVID-19 in the Emergency Department, The Journal of Infectious Diseases, Volume 223, Issue 8, 15 April 2021, Pages 1497–1499; DOI: doi.org/10.1093/infdis/jiab042

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  • Snakemake Workflows for Long-read Bacterial Genome Assembly and Evaluation

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  • Sonication versus the conventional method for evaluation of the dental microbiome: a prospective pilot study

    Wagendorf O, Menzel P, Schwarzer R, Neckel N, Preissner S, Heiland M, Nahles S. Sonication versus the conventional method for evaluation of the dental microbiome: a prospective pilot study. BMC Oral Health. 2022 Aug 12;22(1):348. doi: 10.1186/s12903-022-02374-0.

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  • Frequent intrathecal production of antibodies to the viral capsid antigen of Epstein-Barr virus in patients with central nervous system post-transplant lymphoproliferative disorder

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  • HE4 as a serum biomarker for the diagnosis of pelvic masses: a prospective, multicenter study in 965 patients

    Braicu EI, Krause CL, Torsten U, Mecke H, Richter R, Hellmeyer L, Lanowska M, Müller B, Koch E, Boenneß-Zaloum J, Ames K, Chekerov R, Hasenbein K, Zimmermann M, Mangler M, Chen F, Tauber R, Sehouli J. BMC Cancer. 2022 Jul 30;22(1):831. doi: 10.1186/s12885-022-09887-5.

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  • The Burden of Hepatitis B, Hepatitis C, and Human Immunodeficiency Viruses in Ovarian Cancer Patients in Nairobi, Kenya

    Wanyama FM, Tauber R, Mokomba A, Nyongesa C, Blanchard V. Infect Dis Rep. 2022 Jun 7;14(3):433-445. doi: 10.3390/idr14030047. PMID: 35735757; PMCID: PMC9222280.

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  • Acidic skin care promotes cutaneous microbiome recovery and skin physiology in an acute stratum corneum stress model

    Fluhr J.W., Menzel P., Schwarzer R., Kaestle B., Arens-Corell M., Praefke L., Tsankov N.K., Nikolaeva D.G., Misery L., Darlenski R., 2022 July 01. DOI: 10.1159/issn.1660-5527

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  • Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy

    Jana Ihlow, Sophia Gross, Leonie Busack, Anne Flörcken, Julia Jesse, Michaela Schwarz, Nina Rosa Neuendorff , Ann-Christin von Brünneck, Ioannis Anagnostopoulos, Seval Türkmen, Igor Wolfgang Blau, Thomas Burmeister, David Horst, Lars Bullinger, Jörg Westermann. Haematologica Early view Nov 11, 2021. DOI: 10.3324/haematol.2021.279134.

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  • Predictors of Serological Response to SARS-CoV-2 Vaccination in Kidney Transplant Patients: Baseline Characteristics, Immunosuppression, and the Role of IMPDH Monitoring.

    Liefeldt, L., Glander, P., Klotsche, J., Straub-Hohenbleicher, H., Budde, K., Eberspächer, B., Friedersdorff, F., Halleck, F., Hambach, P., Hofmann, J., Koch, N., Schmidt, D., Schrezenmeier, E., Seelow, E., Weber, U., Zukunft, B., Eckardt, K.U., Choi, M., Bachmann, F., Waiser, J., J Clin Med. 2022;11(6)., PMC: PMC8953201, doi: 10.3390/jcm11061697

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  • Simultaneous newborn screening for sickle cell disease, biotinidase deficiency, and hereditary tyrosinemia type 1 with an optimized tandem mass spectrometry protocol

    Stephan Lobitz 1, Claudia Frömmel 2, Annemarie Brose 3, Oliver Blankenstein 3, Charles Turner 4, R Neil Dalton 4, Yvonne Daniel 4, Jeannette Klein 3 Ann Hematol. 2022 Mar 16, PMID: 35293609 doi: 10.1007/s00277-022-04811-0

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  • Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation

    Baumann U, Schulte JH, Groß JP, Beier R, Ludwig M, Wahn V, Hofmann J, Maecker-Kolhoff B, Sauer M, Kaiser-Labusch P, Karimian N, Blume-Peytavi U, Ghoreschi F, Ott H, Perelygina L, Klemann C, Blankenstein O, von Bernuth H, Krüger R. Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation. Front Immunol. 2022 Jun 2;13:886540. doi: 10.3389

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  • Declining Course of Humoral Immune Response in Initially Responding Kidney Transplant Recipients after Repeated SARS-CoV-2 Vaccination

    Ronicke S, Osmanodja B, Budde K, Jens A, Hammett C, Koch N, Zukunft B, Bachmann F, Choi M, Weber U, Eberspächer B, Hofmann J, Grunow F, Mikhailov M, Halleck F, Schrezenmeier E. Declining Course of Humoral Immune Response in Initially Responding Kidney Transplant Recipients after Repeated SARS-CoV-2 Vaccination. J Clin Med. 2022 Jun 8;11(12):3291. doi: 10.3390

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  • Mycobacterium tuberculosis-specific CD4 T-cell scoring discriminates tuberculosis infection from disease

    Andrej Mantei, Tim Meyer, Mariana Schürmann, Christiane Beßler, Harald Bias, David Krieger, Torsten Bauer, Petra Bacher, Johannes Helmuth, Hans-Dieter Volk, Dirk Schürmann, Alexander Scheffold, Christian Meisel. Eur Respir J. 2022 May 26. PMID: 35618277. DOI: 10.1183/13993003.01780-2021.

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  • Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies

    Bengisu Akbil,Tim Meyer, Paula Stubbemann, Charlotte Thibeault, Olga Staudacher, Daniela Niemeyer, Jenny Jansen, Barbara Mühlemann, Jan Doehn, Christoph Tabeling, Christian Nusshag, Cédric Hirzel, David Sökler Sanchez, Alexandra Nieters, Achim Lother, Daniel Duerschmied, Nils Schallner, Jan Nikolaus Lieberum, Dietrich August, Siegbert Rieg, Valeria Falcone, Hartmut Hengel, Uwe Kölsch, Nadine Unterwalder, Ralf Harto Hübner, Terry C. Jones, Norbert Suttorp, Christian Drosten, Klaus Warnatz, Thibaud Spinetti, Joerg C. Schefold, Thomas Dörner, Leif Erik Sander, Victor M. Corman, Uta Merle, Pa COVID study Group, Florian Kurth, Horst von Bernuth, Christian Meisel, Christine Goffinet. J Clin Immunol. 2022 May 5;1-19. PMID: 35511314. DOI: 10.1007/s10875-022-01252-2.

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  • Serological Response to Three, Four and Five Doses of SARS-CoV-2 Vaccine in Kidney Transplant Recipients

    Osmanodja B, Ronicke S, Budde K, Jens A, Hammett C, Koch N, Seelow E, Waiser J, Zukunft B, Bachmann F, Choi M, Weber U, Eberspächer B, Hofmann J, Grunow F, Mikhailov M, Liefeldt L, Eckardt KU, Halleck F, Schrezenmeier E. Serological Response to Three, Four and Five Doses of SARS-CoV-2 Vaccine in Kidney Transplant Recipients J. Clin. Med. 2022, 11(9), 2565; https://doi.org/10.3390/jcm11092565

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  • SIGLEC1 enables straightforward assessment of type I interferon activity in idiopathic inflammatory myopathies

    Manuel Graf, Sae Lim von Stuckrad, Akinori Uruha, Jens Klotsche, Lydia Zorn-Pauly, Nadine Unterwalder, Thomas Buttgereit, Martin Krusche, Christian Meisel, Gerd R Burmester, Falk Hiepe, Robert Biesen, Tilmann Kallinich, Werner Stenzel, Udo Schneider, Thomas Rose. RMD Open. 2022 Feb;8(1):e001934. PMID: 35177553. DOI: 10.1136/rmdopen-2021-001934.

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  • Knowledge transfer to enhance the performance of deep learning models for automated classification of B cell neoplasms

    Mallesh N, Zhao M, Meintker L, Höllein A, Elsner F, Lüling H, Haferlach T, Kern W, Westermann J, Brossart P, Krause SW, Krawitz PM. Patterns (N Y). 2021 Sep 17;2(10):100351Epub. doi: 10.1016/j.patter.2021.100351. eCollection 2021 Oct 8

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  • External Validation of Five Scores to Predict Stroke-Associated Pneumonia and the Role of Selected Blood Biomarkers

    Hotter B, Hoffmann S, Ulm L, Meisel C, Bustamante A, Montaner J, Katan M, Smith CJ, Meisel A. Stroke. 2021Jan;52(1):325-330. Epub 2020 Dec 7. PMID:33280547. doi: 10.1161/STROKEAHA.120.031884. Epub 2020 Dec 7. PMID:33280547.

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  • SARS-CoV-2 infection and transmission in school settings during the second COVID-19 wave: a cross-sectional study, Berlin, Germany, November 2020

    Theuring S, Thielecke M, van Loon W, Hommes F, Hülso C, von der Haar A, Körner J, Schmidt M, Böhringer F, Mall MA, Rosen A, von Kalle C, Kirchberger V, Kurth T, Seybold J, Mockenhaupt FP; BECOSS Study Group. Euro Surveill. 2021 Aug;26(34):2100184.

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  • Hantavirus Disease: An Update

    Hofmann J, Loyen M, Faber M, Krüger DH. Hantavirus Disease: An Update. Dtsch Med Wochenschr. 2022 Mar;147(6):312-318. doi: 10.1055/a-1664-7259.

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  • Autochthonous West Nile virus infection in Germany: Increasing numbers and a rare encephalitis case in a kidney transplant recipient

    Schneider J, Bachmann F, Choi M, Kurvits L, Schmidt ML, Bergfeld L, Meier I, Zuchowski M, Werber D, Hofmann J, Ruprecht K, Eckardt KU, Jones TC, Drosten C, Corman VM. Autochthonous West Nile virus infection in Germany: Increasing numbers and a rare encephalitis case in a kidney transplant recipient. Transbound Emerg Dis. 2022 Mar;69(2):221-226. doi: 10.1111/tbed.

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  • Cluster of human Puumala orthohantavirus infections due to indoor exposure?-An interdisciplinary outbreak investigation

    Princk C, Drewes S, Meyer-Schlinkmann KM, Saathoff M, Binder F, Freise J, Tenner B, Weiss S, Hofmann J, Esser J, Runge M, Jacob J, Ulrich RG, Dreesman J.Cluster of human Puumala orthohantavirus infections due to indoor exposure?-An interdisciplinary outbreak investigation. Zoonoses Public Health. 2022 Mar 21. doi: 10.1111/zph.12940

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  • Safety of Uncrossmatched ABO-Compatible RBCs in Alloimmunized Patients with Bleeding: Data from Two Decades: Results of a Systematic Analysis in 6,109 Patients

    Frauke Ringel, Helge Schoenfeld, Said El Bali, Jalid Sehouli, Claudia Spies, Abdulgabar Salama. Transfusion Medicine Hemotherapy (08.12.2021). Doi: 10.1159/000520649

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  • Single oral doses of MK-8507, a novel non-nucleoside reverse transcriptase inhibitor, suppress HIV-1 RNA for a week

    Schürmann D, Rudd DJ, Schaeffer A, de Lepeleire I, Friedman EJ, Robberechts M, Zhang S, Liu Y, Kandala B, Keicher C, Däumer M, Hofmann J, Grobler JA, Stoch SA, Iwamoto M, Ankrom W. Single oral doses of MK-8507, a novel non-nucleoside reverse transcriptase inhibitor, suppress HIV-1 RNA for a week. J Acquir Immune Defic Syndr. 2022,89,191-198

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  • Advanced sequencing approaches detected insertions of viral and human origin in the viral genome of chronic hepatitis E virus patients

    C.-Patrick Papp, Paula Biedermann, Dominik Harms, Bo Wang, Marianne Kebelmann, Mira Choi, Johannes Helmuth, Victor M. Corman, Andrea Thürmer, Britta Altmann, Patrycja Klink, Jörg Hofmann & C.-Thomas Bock. Scientific Reports 12, 1720 (2022). DOI:10.1038/s41598-022-05706-w

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  • Comprehensive analysis and mathematical modelling of hemolysis impacting on potassium levels in patients with and without renal impairment.

    Jahic A, Prpic M, Neuwinger N, Kappert K., Clin Biochem. 2022 Jan 10:S0009-9120(22)00002-9. DOI: 10.1016/j.clinbiochem.2022.01.002

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  • SARS-CoV-2 screening in patients in need of urgent inpatient treatment in the Emergency Department (ED) by digitally integrated point-of-care PCR: a clinical cohort study

    Möckel M, Bolanaki M, Hofmann J, Stein A, Hitzek J, Holert F, Fischer-Rosinský A, Slagman A. SARS-CoV-2 screening in patients in need of urgent inpatient treatment in the Emergency Department (ED) by digitally integrated point-of-care PCR: a clinical cohort study. Diagn Microbiol Infect Dis. 2022 Jan 16;102(4):115637

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  • Complement activation induces excessive T cell cytotoxicity in severe COVID-19

    Philipp Georg, Rosario Astaburuaga-García, Lorenzo Bonaguro, Sophia Brumhard, Laura Michalick, Lena J. Lippert, Tomislav Kostevc, Christiane Gäbel, Maria Schneider, Mathias Streitz, Vadim Demichev, Ioanna Gemünd, Matthias Barone, Pinkus Tober-Lau, Elisa T. Helbig, David Hillus, Lev Petrov, Julia Stein, Hannah-Philine Dey, Daniela Paclik, Christina Iwert, Michael Mülleder, Simran Kaur Aulakh, Sonja Djudjaj, Roman D. Bülow, Henrik E. Mei, Axel R. Schulz, Andreas Thiel, Stefan Hippenstiel, Antoine-Emmanuel Saliba, Roland Eils, Irina Lehmann, Marcus A. Mall, Sebastian Stricker, Jobst Röhmel, Victor M. Corman, Dieter Beule, Emanuel Wyler, Markus Landthaler, Benedikt Obermayer, Saskiavon Stillfried, Peter Boor, Münevver Demir, Hans Wesselmann, Norbert Suttorp, Alexander Uhrig, Holger Müller-Redetzky, Jacob Nattermann, Wolfgang M. Kuebler, Christian Meisel, Markus Ralser, Joachim L. Schultze, Anna C. Aschenbrenner, Charlotte Thibeault, Florian Kurth, PA-COVID-19 Study group, Leif E. Sander, Nils Blüthgen, Birgit Sawitzki. DOI: https://doi.org/10.1016/j.cell.2021.12.040. Cell, in Press

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  • Evaluation of SIGLEC1 in the diagnosis of suspected systemic lupus erythematosus

    Lydia Zorn-Pauly , Anne Sae Lim von Stuckrad, Jens Klotsche, Thomas Rose, Tilmann Kallinich, Philipp Enghard, Lennard Ostendorf, Marie Burns, Thomas Doerner, Christian Meisel, Udo Schneider, Nadine Unterwalder, Gerd Burmester, Falk Hiepe, Tobias Alexander, Robert Biesen. Rheumatology (Oxford). 2021 Nov 27. PMID: 34849605 . DOI: 10.1093/rheumatology/keab875

  • Precision medicine in myeloid malignancies

    Jörg Westermann, Lars Bullinger . Seminars in Cancer Biology 2021 Apr 22; S1044-579X(21)00084-5. PMID: 33895273 DOI: 10.1016/j.semcancer.2021.03.034

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  • Consequences of the SARS-CoV-2 Pandemia on the Early Childhood Examinations

    Blankenstein O, Rintisch W, Buchholz T, Lüder S, Bartezky R, Kolbow D, Dame C. Klin Padiatr. 2020 Sep 1. German. doi: 10.1055/a-1247-5119. PMID: 32871606.

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  • Aktivierung und Regulierung des platelet-derived growth factor (PDGF) Rezeptor β bei der Myelofibrose

    Frederike Kramer, Jens Dernedde, Artur Mezheyeuski, Rudolf Tauber, Patrick Micke and Kai Kappert. Haematologica 2020 Volume 105(8):2083-2094. doi: 10.3324/haematol.2019.226332

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  • Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

    Mario Witkowski, Caroline Tizian, Marta Ferreira-Gomes, Uwe Kölsch, Christian Meisel, Victor M.Corman, Christian Drosten […] Andreas Diefenbach

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  • Long-term immunogenicity of BNT162b2 vaccination in older people and younger health-care workers

    Tober-Lau P, Schwarz T, Vanshylla K, Hillus D, Gruell H, the EICOV/COVIM Study Group, Suttorp N, Landgraf I, Kappert K, Seybold J, Drosten C, Klein F, Kurth F, Sander LE, Corman VM. Lancet Respir Med

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  • CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells

    Bunse M, Pfeilschifter J, Bluhm J, Zschummel M, Joedicke JJ, Wirges A, Stark H, Kretschmer V, Chmielewski M, Uckert W, Abken H, Westermann J, Rehm A, Höpken UE. Nature Communications. doi: 10.1038/s41467-020-20488-3. PMID: 33431832

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  • Assessment of serum ferritin as a biomarker in COVID-19: bystander or participant? Insights by comparison with other infectious and non-infectious diseases

    Kappert K, Jahić A, Tauber R. Biomarkers. 2020 Dec;25(8):616-625. PMID: 32700561 DOI: 10.1080/1354750X.2020.1797880

  • Performance evaluation of the Roche Elecsys Anti-SARS-CoV-2 S immunoassay

    Riester E, Findeisen P, Hegel JK, Kabesch M, Ambrosch A, Rank CM, Pessl F, Laengin T, Niederhauser C.J Virol Methods. 2021 Aug 27:114271. Link: doi: 10.1016/j.jviromet.2021.114271.

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  • A Single dose of the Biontech/Pfizer BNT162b2 vaccine protected elderly residents from severe COVID-19 during a SARS-Coronavirus-2 outbreak in a senior citizen home in Germany.

    R. Schwarzer, S. D. Freys, N. Neuwinger, N. Beikert, B. Eberspaecher, A. Edelmann, M. Zuchowski, I. Slothouwer, A. Stein, K. Theil, P. Menzel, and J. Hofmann. Journal: Immunity, Inflammation and Disease, EPub ahead of Print

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  • Clinical outcome of older adults with acute myeloid Leukemia: An analysis of a large tertiary referral Center over two decades.

    Ihlow J, Gross S, Neuendorff NR, Busack L, Herneth A, Singh A, Schwarz M, Flörcken A, Anagnostopoulos I, Türkmen S, Burmeister T, Blau IW, Bullinger L, Westermann J. J Geriatr Oncol. 2021 May;12(4):540-549. doi: 10.1016/j.jgo.2020.11.001. Epub 2020 Nov 19. PMID: 33223482

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  • Outcome prediction by serum calprotectin in patients with COVID-19 in the emergency department

    Wolfgang Bauer 1, Eva Diehl-Wiesenecker 2, Jannis Ulke 3, Noa Galtung 2, Aleksandra Havelka 4, J Kolja Hegel 5, Rudolf Tauber 6, Rajan Somasundaram 2, Kai Kappert 6 J Infect. 2021 Apr;82(4):84-123. doi: 10.1016/j.jinf.2020.11.016 PMID: 33217473 PMCID: PMC7670934 DOI: 10.1016/j.jinf.2020.11.016

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  • Dysbiosis and Enhanced Beta-Defensin Production in Hair Follicles of Patients with Lichen Planopilaris and Frontal Fibrosing Alopecia

    Andria Constantinou, Katarzyna Polak-Witka, Marios Tomazou, Anastasis Oulas, Varvara Kanti, Rolf Schwarzer, Johannes Helmuth, Anke Edelmann, Ulrike Blume-Peytavi, George M. Spyrou, Annika Vogt. Biomedicines 2021, 9(3), 266

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  • Immature Platelet Counts and Thrombopoietin Plasma Concentrations in Thrombocytopenic and Non-thrombocytopenic Preterm Infants

    Hannes Sallmon, Andreas Weimann, Christoph Bührer, Boris Metze, Christof Dame, Malte Cremer Front. Pediatr., 25 June 2021

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  • Precision medicine in myeloid malignancies

    Westermann J, Bullinger L. Seminars in Cancer Biology, 22 Apr 2021, DOI: 10.1016/j.semcancer.2021.03.034 PMID: 33895273

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  • Immunogenicity of COVID-19 Tozinameran Vaccination in Patients on Chronic Dialysis

    Schrezenmeier E, Bergfeld L, Hillus D, Lippert JD, Weber U, Tober-Lau P, Landgraf I, Schwarz T, Kappert K, Stefanski AL, Sattler A, Kotsch K, Dörner T, Sander LE, Budde K, Halleck F, Kurth F, Corman VM, Choi M. Front Immunol. 2021 Jun 30;12:690698.

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  • Glycosylation is a key in SARS-CoV-2 infection

    Reis CA, Tauber R, Blanchard V. J Mol Med (Berl). 2021 May 22:1–9. doi: 10.1007/s00109-021-02092-0. Epub ahead of print.

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  • Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany

    Tatjana Schwarz, Pinkus Tober-Lau, David Hillus, Elisa T Helbig, Lena J Lippert, Charlotte Thibeault, Willi Koch, Irmgard Landgraf, Janine Michel, Leon Bergfeld, Daniela Niemeyer, Barbara Mühlemann, Claudia Conrad, Chantip Dang-Heine, Stefanie Kasper, Friederike Münn, Kai Kappert, Andreas Nitsche, Rudolf Tauber, Sein Schmidt, Piotr Kopankiewicz, Harald Bias, Joachim Seybold, Christof von Kalle, Terry C Jones, Norbert Suttorp, Christian Drosten, Leif Erik Sander, Victor M Corman, Florian Kurth Emerging Infectious Diseases 2021 Jun 8;27(8). doi: 10.3201/eid2708.211145

  • Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis.

    Yamaguchi Y, Saito A, Horie M, Aoki A, Micke P, Ohshima M, Kappert K. Odontology. 2021 Jun 14. doi: 10.1007/s10266-021-00625-0. Online ahead of print.

  • Mild COVID-19 despite autoantibodies to type I IFNs in Autoimmune-Polyendocrine-Syndrome Type 1 (APS-1)

    Christian Meisel*, Bengisu Akbil*, Tim Meyer, Erwin Lankes, Victor M. Corman, Olga Staudacher, Nadine Unterwalder, Uwe Kölsch, Christian Drosten, Marcus A. Mall, Tilmann Kallinich, Dirk Schnabel, Christine Goffinet and Horst von Bernuth. Journal of Clinical Investigation, 2021.

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  • Draft Genome Sequence of Mycobacteroides sp. Strain LB1, Isolated from the Sputum of a Cystic Fibrosis Patient

    Peter Menzel, Rolf Schwarzer, Johannes Helmuth and Inna Friesen, DOI: https://doi.org/10.1128/MRA.00797-20

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  • Estimating infectiousness throughout SARS-CoV-2 infection course

    View ORCID ProfileTerry C. Jones1,2,3,†, View ORCID ProfileGuido Biele4,5,†, View ORCID ProfileBarbara Mühlemann1,2, View ORCID ProfileTalitha Veith1,2, View ORCID ProfileJulia Schneider1,2, Jörn Beheim-Schwarzbach1, Tobias Bleicker1, Julia Tesch1, Marie Luisa Schmidt1, View ORCID ProfileLeif Erik Sander6, View ORCID ProfileFlorian Kurth6,7, View ORCID ProfilePeter Menzel8, View ORCID ProfileRolf Schwarzer8, View ORCID ProfileMarta Zuchowski8, Jörg Hofmann8, Andi Krumbholz9,10, Angela Stein8, View ORCID ProfileAnke Edelmann8, View ORCID ProfileVictor Max Corman1,2, View ORCID ProfileChristian Drosten1,2,* DOI: 10.1126/science.abi5273

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  • Mutation spectrum and polygenic score in German patients with familial hypercholesterolemia

    Lorenz Rieck 1, Frieda Bardey 1, Thomas Grenkowitz 2, Lars Bertram 3 4, Johannes Helmuth 5, Claudia Mischung 5, Joachim Spranger 1, Elisabeth Steinhagen-Thiessen 1, Thomas Bobbert 1, Ursula Kassner 1, Ilja Demuth 1 6; PMID: 32770674, DOI: 10.1111/cge.13826

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  • Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

    Aschenbrenner AC, Mouktaroudi M, Krämer B, Oestreich M, Antonakos N, Nuesch-Germano M, Gkizeli K, Bonaguro L, Reusch N, Baßler K, Saridaki M, Knoll R, Pecht T, Kapellos TS, Doulou S, Kröger C, Herbert M, Holsten L, Horne A, Gemünd ID, Rovina N, Agrawal S, Dahm K, van Uelft M, Drews A, Lenkeit L, Bruse N, Gerretsen J, Gierlich J, Becker M, Händler K, Kraut M, Theis H, Mengiste S, De Domenico E, Schulte-Schrepping J, Seep L, Raabe J, Hoffmeister C, ToVinh M, Keitel V, Rieke G, Talevi V, Skowasch D, Aziz NA, Pickkers P, van de Veerdonk FL, Netea MG, Schultze JL, Kox M, Breteler MMB, Nattermann J, Koutsoukou A, Giamarellos-Bourboulis EJ, Ulas T; German COVID-19 OMICSInitiative (DeCOI). 2021. Genome Med. 13:7.

  • SARS-CoV-2 in severe COVID-19 induces a TGF-b-dominated chronic immune response that does not target itself

    Ferreira-Gomes, M., A.Kruglov, P.Durek, F.Heinrich, C.Tizian, G.Heinz, A.Pascual-Reguant, Weijie Du, R.Mothes, C.Fan, S.Frischbutter, K.Habenicht, L.Budzinski, J.Ninnemann, P.Jani, G.Guerra, K.Lehmann, M.Matz, L.Ostendorf, L.Heiberger, H-D.Chang, S.Bauherr, M.Maurer, G.Schönrich, M.Raftery, T.Kallinich, M.Mall, S.Angermair, S.Treskatsch, T.Dörner, V.Corman, A.Diefenbach, H-D.Volk, S.Elezkurtaj, T.Winkler, J.Dong, A.Hauser, H.Radbruch, M.Witkowski, F.Melchers, A.Radbruch, and M-F.Mashreghi. 2021. Nature Communications. in press

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  • CD4+ T cells promote delayed B cell responses in theischemic brain after experimental stroke

    Weitbrecht L, Berchtold D, Zhang T, Jagdmann S, Dames C, Winek K, Meisel C,Meisel A. Brain Behav Immun. 2021Jan;91:601-614. doi: 10.1016/j.bbi.2020.09.029. Epub 2020 Sep 28. PMID:33002634.

  • External Validation of Five Scores to Predict Stroke-Associated Pneumonia and the Role of Selected Blood Biomarkers

    Hotter B, Hoffmann S, Ulm L, Meisel C, Bustamante A, Montaner J, Katan M, Smith CJ, Meisel A. Stroke. 2021Jan;52(1):325-330. doi: 10.1161/STROKEAHA.120.031884. Epub 2020 Dec 7. PMID:33280547.

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  • Head-to-head comparison of SARS-CoV-2 antigen-detecting rapid test with self-collected anterior nasal swab vs professional-collected nasopharyngeal swab.

    Lindner AK, Nikolai O, Kausch F, Wintel M, Hommes F, Gertler M, Krüger LJ, Gaeddert M, Tobian F, Lainati F, Köppel L, Seybold J, Corman VM, Drosten C, Hofmann J, Sacks JA, Mockenhaupt FP, Denkinger CM. Eur Respir J. 2020 Dec 10:2003961.

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  • Role of cell adhesion molecules for disease development of patients with and without COVID-19 in the emergency department.

    Bauer W, Ulke J, Galtung N, Strasser-Marsik LC, Neuwinger N, Tauber R, Somasundaram R, Kappert K. J Infect Dis. 2021 Apr 23;223(8):1497-1499. doi: 10.1093/infdis/jiab042.

  • Matter of Caution: Coagulation Parameters in COVID-19 Do Not Differ from Patients with Ruled-Out SARS-CoV-2 Infection in the Emergency Department.

    Bauer W, Galtung N, Neuwinger N, Kaufner L, Langer E, Somasundaram R, Tauber R, Kappert K. A TH Open. 2021 Feb 6;5(1):e43-e55. doi: 10.1055/s-0040-1722612.

  • Nuclear antigen-reactive CD4+ T cells expand in active systemic lupus erythematosus,produce effector cytokines, and invade the kidneys.

    Abdirama D, Tesch S, Grießbach AS, von Spee-Mayer C, Humrich JY, Stervbo U,Babel N, Meisel C, Alexander T, Biesen R, Bacher P, Scheffold A, Eckardt KU,Hiepe F, Radbruch A, Burmester GR, Riemekasten G, Enghard P. Kidney Int.2021Jan;99(1):238-246. doi: 10.1016/j.kint.2020.05.051. PMID:32592813.

  • Novichok nerve agent poisoning

    CASE REPORT| VOLUME 397, ISSUE 10270, P249-252, JANUARY 16, 2021 David Steindl, MD Wolfgang Boehmerle, MD Roland Körner, MD Damaris Praeger, MD Marcel Haug, MD Jens Nee, MD et al. Show all authors Published:December 22, 2020DOI:https://doi.org/10.1016/S0140-6736(20)32644-1

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  • Enhancing the differentiation of pulmonary lymphoma and fungal pneumonia in hematological patients using texture analysis in 3-T MRI.

    Kim D, Elgeti T, Penzkofer T, Steffen IG, Jensen LJ, Schwartz S, Hamm B, Nagel SN. Eur Radiol. 2021 Feb;31(2):695-705. doi: 10.1007/s00330-020-07137-5. Epub 2020 Aug 21. PMID: 32822054 Free PMC article.

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  • Long-term outcomes with frontline nilotinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: ENESTnd 10-year analysis.

    Kantarjian HM, Hughes TP, Larson RA, Kim DW, Issaragrisil S, le Coutre P, Etienne G, Boquimpani C, Pasquini R, Clark RE, Dubruille V, Flinn IW, Kyrcz-Krzemien S, Medras E, Zanichelli M, Bendit I, Cacciatore S, Titorenko K, Aimone P, Saglio G, Hochhaus A. Leukemia. 2021 Feb;35(2):440-453. doi: 10.1038/s41375-020-01111-2. Epub 2021 Jan 7. PMID: 33414482 Free PMC article.

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  • Predicting sinusoidal obstruction syndrome after allogeneic stem cell transplantation with the EASIX biomarker panel.

    Jiang S, Penack O, Terzer T, Schult D, Majer-Lauterbach J, Radujkovic A, Blau IW, Bullinger L, Müller-Tidow C, Dreger P, Luft T. Haematologica. 2021 Feb 1;106(2):446-453. doi: 10.3324/haematol.2019.238790. PMID: 31974195 Free PMC article.

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  • B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased.

    Ihlow J, Michaelis E, Greuel S, Heynol V, Lehmann A, Radbruch H, Meinhardt J, Miller F, Herbst H, Corman VM, Westermann J, Bullinger L, Horst D, von Brünneck AC, Elezkurtaj S. Int J Infect Dis. 2021 Feb;103:628-635. doi: 10.1016/j.ijid.2020.12.078. Epub 2021 Jan 2. PMID: 33401036 Free PMC article.

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  • Impact of a specialised palliative care intervention in patients with advanced soft tissue sarcoma – a single-centre retrospective analysis.

    Brandes F, Striefler JK, Dörr A, Schmiester M, Märdian S, Koulaxouzidis G, Kaul D, Behzadi A, Thuss-Patience P, Ahn J, Pelzer U, Bullinger L, Flörcken A. BMC Palliat Care. 2021 Jan 14;20(1):16. doi: 10.1186/s12904-020-00702-1. PMID: 33446180 Free PMC article.

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  • Early bilirubinemia after allogeneic stem cell transplantation-an endothelial complication.

    Dai H, Penack O, Radujkovic A, Schult D, Majer-Lauterbach J, Blau IW, Bullinger L, Jiang S, Müller-Tidow C, Dreger P, Luft T. Bone Marrow Transplant. 2021 Jan 30. doi: 10.1038/s41409-020-01186-6. Online ahead of print. PMID: 33517355

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  • B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased.

    Ihlow J, Michaelis E, Greuel S, Heynol V, Lehmann A, Radbruch H, Meinhardt J, Miller F, Herbst H, Corman VM, Westermann J, Bullinger L, Horst D, von Brünneck AC, Elezkurtaj S. Int J Infect Dis. 2021 Feb;103:628-635. doi: 10.1016/j.ijid.2020.12.078. Epub 2021 Jan 2. PMID: 33401036 Free PMC article.

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  • CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells.

    Bunse M, Pfeilschifter J, Bluhm J, Zschummel M, Joedicke JJ, Wirges A, Stark H, Kretschmer V, Chmielewski M, Uckert W, Abken H, Westermann J, Rehm A, Höpken UE. Nat Commun. 2021 Jan 11;12(1):240. doi: 10.1038/s41467-020-20488-3. PMID: 33431832 Free PMC article.

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  • Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia.

    Rapaport F, Neelamraju Y, Baslan T, Hassane D, Gruszczynska A, Robert de Massy M, Farnoud N, Haddox S, Lee T, Medina-Martinez J, Sheridan C, Thurmond A, Becker M, Bekiranov S, Carroll M, Moses Murdock H, Valk PJM, Bullinger L, D’Andrea R, Lowe SW, Neuberg D, Levine RL, Melnick A, Garrett-Bakelman FE. Leukemia. 2021 Feb 12. doi: 10.1038/s41375-021-01153-0. Online ahead of print. PMID: 33580203 No abstract available.

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  • Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin.

    Schmalbrock LK, Dolnik A, Cocciardi S, Sträng E, Theis F, Jahn N, Panina E, Blätte TJ, Herzig JK, Skambraks S, Rücker FG, Gaidzik VI, Paschka P, Fiedler W, Salih HR, Wulf GG, Schroeder T, Lübbert M, Schlenk RF, Thol F, Heuser M, Larson RA, Ganser A, Stunnenberg HG, Minucci S, Stone RM, Bloomfield CD, Döhner H, Döhner K, Bullinger L. Blood. 2021 Feb 17:blood.2020007626. doi: 10.1182/blood.2020007626. Online ahead of print. PMID: 33598693

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  • Long-term in vitro expansion ensures increased yield of central memory T cells as perspective for manufacturing challenges.

    Herda S, Heimann A, Obermayer B, Ciraolo E, Althoff S, Ruß J, Grunert C, Busse A, Bullinger L, Pezzutto A, Blankenstein T, Beule D, Na IK. Int J Cancer. 2021 Feb 18. doi: 10.1002/ijc.33523. Online ahead of print. PMID: 33600609

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  • Serum cytokines and theirpredictive value in pulmonary involvement of systemic sclerosis

    Becker MO, Radic M, Schmidt K, Huscher D, Riedlinger A, Michelfelder M,Meisel C, Ewert R, Burmester GR, Riemekasten G. SarcoidosisVasc Diffuse Lung Dis. 2019;36(4):274-284. doi: 10.36141/svdld.v36i4.7612. Epub2019 May 1. PMID: 32476963; PMCID: PMC7247092.

  • IL-6 PlasmaLevels Correlate With Cerebral Perfusion Deficits and Infarct Sizes in StrokePatients Without Associated Infections.

    Hotter B, Hoffmann S, Ulm L, Meisel C, Fiebach JB, Meisel A. Front Neurol. 2019 Feb 15;10:83. doi:10.3389/fneur.2019.00083. PMID: 30828313; PMCID: PMC6384225.

  • Screening and treatment for tuberculosis in a cohort ofunaccompanied minor refugees in Berlin, Germany

    Thee S, Krüger R, von Bernuth H, Meisel C, Kölsch U, Kirchberger V,Feiterna-Sperling C. PLoS One. 2019 May21;14(5):e0216234. doi: 10.1371/journal.pone.0216234. PMID: 31112542; PMCID:PMC6528979.

  • Killer-like receptors and GPR56progressive expression defines cytokine production of human CD4+memory T cells.

    Truong KL, Schlickeiser S, Vogt K, Boës D, Stanko K, Appelt C, Streitz M,Grütz G, Stobutzki N, Meisel C, et al. Nat Commun. 2019 May 22;10(1):2263. doi:10.1038/s41467-019-10018-1. PMID: 31118448; PMCID: PMC6531457.

  • Biomarkers of immune capacity, infection andinflammation are associated with poor outcome and mortality after stroke – thePREDICT study

    Mengel A, Ulm L, Hotter B, Harms H, Piper SK, Grittner U, Montaner J, MeiselC, Meisel A, Hoffmann S. BMC Neurol. 2019 Jul 3;19(1):148. doi: 10.1186/s12883-019-1375-6.PMID: 31269910; PMCID: PMC6607590.

  • Clinical research assessment by flowcytometry of biomarkers for infectious stratification in an EmergencyDepartment

    Bourgoin P, Soliveres T, Ahriz D, Arnoux I, Meisel C, Unterwalder N, MorangePE, Michelet P, Malergue F, Markarian T. Biomark Med. 2019 Nov;13(16):1373-1386. doi: 10.2217/bmm-2019-0214.Epub 2019 Oct 16. PMID: 31617736.

  • Diagnostic biomarkers for adult haemophagocytic lymphohistiocytosis incritically ill patients (HEMICU): a prospective observational study protocol.

    Lachmann G, Knaak C, von Haefen C, Paeschke N, Meisel C, et al. BMJ Open. 2019 Oct 30;9(10):e032695. doi: 10.1136/bmjopen-2019-032695. PMID:31666276; PMCID: PMC6830715.

  • Current gaps in sepsis immunology: new opportunities for translational research

    Rubio I, Osuchowski MF, Shankar-Hari M, Skirecki T, Winkler MS, Lachmann G,La Rosée P, Monneret G, Venet F, Bauer M, Brunkhorst FM, Kox M, Cavaillon JM,Uhle F, Weigand MA, Flohé SB, Wiersinga WJ, Martin-Fernandez M, Almansa R,Martin-Loeches I, Torres A, Giamarellos-Bourboulis EJ, Girardis M, Cossarizza A,Netea MG, van der Poll T, Scherag A, Meisel C, Schefold JC, Bermejo-Martín JF. Lancet Infect Dis. 2019 Dec;19(12):e422-e436. doi:10.1016/S1473-3099(19)30567-5. Epub 2019 Oct 17. PMID: 31630991.

  • Daratumumab treatment for therapy-refractoryanti-CASPR2 encephalitis.

    Scheibe F, Ostendorf L, Reincke SM, Prüss H, von Brünneck AC, Köhnlein M,Alexander T, Meisel C, Meisel A. J Neurol. 2020 Feb;267(2):317-323. doi:10.1007/s00415-019-09585-6. Epub 2019 Oct 19. PMID: 31630242.

  • T Cell Impairment Is Predictive for a Severe Clinical Course in NEMODeficiency.

    Heller S, Kölsch U, Magg T, Krüger R, Scheuern A, Schneider H, Eichinger A,Wahn V, Unterwalder N, Lorenz M, Schwarz K, Meisel C, Schulz A, Hauck F, vonBernuth H. J Clin Immunol. 2020 Apr;40(3):421-434. doi:10.1007/s10875-019-00728-y. Epub 2020 Jan 21. PMID: 31965418.

  • Immune biomarker-basedenrichment in sepsis trials. Crit Care.

    Spinetti T, Meisel C, von Gunten S, Schefold JC. 2020 Feb 19;24(1):58. doi:10.1186/s13054-020-2774-1. PMID: 32075672; PMCID: PMC7029545.

  • Inflammatory and stress markers predicting pneumonia, outcome, and etiology inpatients with stroke: Biomarkers for predicting pneumonia, functional outcome,and death after stroke

    Hotter B, Hoffmann S, Ulm L, Montaner J, Bustamante A, Meisel C, Meisel A. Neurol Neuroimmunol Neuroinflamm. 2020 Feb 25;7(3):e692.doi: 10.1212/NXI.0000000000000692. PMID: 32098866; PMCID: PMC7051196.

  • Acute nicotine administration stimulatesciliary activity via α3β4 nAChR in the mouse trachea.

    Perniss A, Latz A, Boseva I, Papadakis T, Dames C, Meisel C, Meisel A,Scholze P, Kummer W, Krasteva-Christ G. Int Immunopharmacol. 2020 Jul;84:106496. doi: 10.1016/j.intimp.2020.106496. Epub 2020 Apr 15. PMID:32304995.

  • Analysis of solubleinterleukin-2 receptor as CSF biomarker for neurosarcoidosis

    Otto C, Wengert O, Unterwalder N, Meisel C, Ruprecht K. NeurolNeuroimmunol Neuroinflamm. 2020 May 11;7(4):e725. doi:10.1212/NXI.0000000000000725. PMID: 32393650; PMCID: PMC7238895.

  • Impact of Key Nicotinic AChR Subunits on Post-Stroke Pneumococcal Pneumonia.

    Jagdmann S, Dames C, Berchtold D, Winek K, Weitbrecht L, Meisel A, Meisel C. Vaccines (Basel). 2020 May 28;8(2):253. doi: 10.3390/vaccines8020253. PMID:32481512; PMCID: PMC7349987.

  • Interaction of microglia withinfiltrating immune cells in the different phases of stroke.

    Berchtold D, Priller J, Meisel C, Meisel A. Brain Pathol. 2020Nov;30(6):1208-1218. doi: 10.1111/bpa.12911. Epub 2020 Nov 2. PMID: 33058417.

  • Presence of anti-neuronal antibodies in children with neurologicaldisorders beyond encephalitis.

    Nikolaus M, Meisel C, Kreye J, Prüss H, Reindl M, Kaindl AM, Schuelke M,Knierim E. Eur J Paediatr Neurol. 2020 Sep;28:159-166. doi:10.1016/j.ejpn.2020.07.004. Epub 2020 Jul 30. PMID: 32807683.

  • CD70Deficiency Associated With Chronic Epstein-Barr Virus Infection, Recurrent Airway Infections and Severe Gingivitis in a 24-Year-Old Woman.

    Krüger R, Martin E, Dmytrus J, Feiterna-Sperling C, Meisel C, et al. Front Immunol. 2020 Aug 4;11:1593. doi: 10.3389/fimmu.2020.01593. PMID: 32849540; PMCID:PMC7417345.

  • SIGLEC1 (CD169) is a sensitive biomarker for thedeterioration of the clinical course in childhood systemic lupus erythematosus.

    Stuckrad SLV, Klotsche J, Biesen R, Lieber M, Thumfart J, Meisel C,Unterwalder N, Kallinich T. Lupus. 2020 Dec;29(14):1914-1925. doi: 10.1177/0961203320965699. Epub 2020 Oct20. PMID: 33081587; PMCID: PMC7684796.

  • SIGLEC1 (CD169) as a potential diagnostical screening marker for monogenic interferonopathies.

    Orak B, Ngoumou G, Ebstein F, Zieba B, Goetzke CC, Knierim E, Kaindl AM, Panzer A, Theophil M, Berns M, Krüger E, Meisel C, Unterwalder N, Kallinich T. Pediatr Allergy Immunol. 2020 Oct 25. doi:10.1111/pai.13400. Epub ahead of print. PMID: 33099809.

  • A case of neonatal onsetmultisystem inflammatory disease supporting a role of interleukin-1β in moyamoyasyndrome.

    Wohlrab F, Bauknecht C, Meisel C, Dreier JP. Neurol Neuroimmunol Neuroinflamm. 2020 Oct 27;8(1):e1-3. doi:10.1212/NXI.0000000000000910. PMID: 33109682.

  • Myositis-specific autoantibodies and their associated phenotypes in juveniledermatomyositis: data from a German cohort.

    Horn S, Minden K, Speth F, Schwarz T, Dressler F, Grösch N, Haas JP, Hinze C,Horneff G, Hospach A, Kallinich T, Klotsche J, Köstner K, Meisel C, et al. Clin Exp Rheumatol. 2020 Oct 29.PMID: 33124555.

  • Newborn Screening for SCID and Other SeverePrimary Immunodeficiency in the Polish-German Transborder Area: Experience From the First 14 Months of Collaboration.

    Giżewska M, Durda K, Winter T, Ostrowska I, Ołtarzewski M, Klein J,Blankenstein O, Romanowska H, Krzywińska-Zdeb E, Patalan MF, Bartkowiak E,Szczerba N, Seiberling S, Birkenfeld B, Nauck M, von Bernuth H, Meisel C, et al. Front Immunol. 2020 Oct 16;11:1948. doi:10.3389/fimmu.2020.01948. PMID: 33178177; PMCID: PMC7596351.

  • Transfer RNA fragments replace microRNA regulators of thecholinergic poststroke immune blockade.

    Winek K, Lobentanzer S, Nadorp B, Dubnov S, Dames C, Jagdmann S, Moshitzky G,Hotter B, Meisel C, et al. Proc Natl Acad Sci U S A. 2020 Dec22;117(51):32606-32616. doi: 10.1073/pnas.2013542117. Epub 2020 Dec 7. PMID:33288717; PMCID: PMC7768686.

  • CD4+ T cells promote delayed B cell responses in theischemic brain after experimental stroke.

    Weitbrecht L, Berchtold D, Zhang T, Jagdmann S, Dames C, Winek K, Meisel C, et al. Brain Behav Immun. 2021Jan;91:601-614. doi: 10.1016/j.bbi.2020.09.029. Epub 2020 Sep 28. PMID:33002634.

  • External Validation of Five Scores to Predict Stroke-Associated Pneumonia and the Role of Selected Blood Biomarkers

    Hotter B, Hoffmann S, Ulm L, Meisel C, et al. Stroke. 2021Jan;52(1):325-330. doi: 10.1161/STROKEAHA.120.031884. Epub 2020 Dec 7. PMID:33280547.

  • Nuclear antigen-reactive CD4+ T cells expand in active systemic lupus erythematosus,produce effector cytokines, and invade the kidneys.

    bdirama D, Tesch S, Grießbach AS, von Spee-Mayer C, Humrich JY, Stervbo U,Babel N, Meisel C, et al. Kidney Int. 2021Jan;99(1):238-246. doi: 10.1016/j.kint.2020.05.051. PMID:32592813.

  • Novichok nerve agent poisoning.

    Steindl D, Boehmerle W, Körner R, Praeger D, Haug M, Nee J, Schreiber A, Scheibe F, Demin K, Jacoby P, Tauber R, Hartwig S, Endres M, Eckardt KU. Lancet. 2020 Dec 22:S0140-6736(20)32644-1. doi: 10.1016/S0140-6736(20)32644-1. Epub ahead of print

  • Outcome prediction by serum calprotectin in patients with COVID-19 in the emergency department

    Bauer W, Diehl-Wiesenecker E, Ulke J; Galtung N; Havelka A, Hegel KJ, Tauber R, Somasundaram R, Kappert K J Infect. 2020 Nov 17:S0163-4453(20)30711-8. doi: 10.1016/j.jinf.2020.11.016.

  • Patients’ Perception of the Diagnosis of Malignancy, and the Overlap with Physicians’ Subjective Assessment in Pelvic Mass Patients. Results of a Multicentric, Prospective Pelvic Mass Study.

    Koch E, Torsten U, Mecke H et al. J Psychosomatic Obstetrics & Gynecology 2020, DOI: 10.1080/0167482X.2020.1850684.

  • Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.

    Schulte-Schrepping J, Reusch N, Paclik D, Baßler K et al. Cell. 2020 Sep 17;182(6):1419-1440.e23. doi:10.1016/j.cell.2020.08.001. Epub 2020 Aug 5. PMID: 32810438; PMCID: PMC7405822.

  • Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis.

    Kramer F, Dernedde J, Mezheyeuski A, Tauber R, Micke P, Kappert K. Haematologica. 2020 Aug;105(8):2083-2094. doi: 10.3324/haematol.2019.226332.

  • Reversal of apixaban induced alterations in haemostasis by different coagulation factor concentrates in patients after hip or knee replacement surgery.

    Schmidt K, Krüger K, Langer E, et al. Blood Transfus. 2019;17(2):157-162. doi:10.2450/2018.0028-18

  • Assessment of serum ferritin as a biomarker in COVID-19: bystander or participant? Insights by comparison with other infectious and non-infectious diseases.

    Kappert, K, Jahic, A., Tauber, R. Biomarkers DOI: 10.1080/1354750X.2020.1797880.

  • Pooling, room temperature and extended storage time increase the release of adult- specific biological response modifiers in platelet packages: A hidden risk for transfusion in neonates.

    Miriam Waubert de Puiseau, Lina K. Sciesielski, Oliver Meyer, Chiara-Aiyleen Badur, Helge Schönfeld, Rudolf Tauber, Axel Pruß and Christof Dame. Transfusion 2020 Apr 27. doi: 10.1111/trf.15827.

  • Use of Relative Ion Intensities for Enhanced Selectivity in a High Pressure Liquid Chromatography – Tandem Mass Spectrometry Method for Iohexol in Human Serum.

    Vincent J. T. Schweinsberg, Stefan Eckelt, Anna M. Schulz, Marcel Arlt, Marc Schumann, Markus van der Giet, Rudolf Tauber, Torsten Binscheck-Domaß, Peggy Kießling. Clinical Chemistry and Laboratory Medicine 58(5):709-718 (2020). doi: 10.1515/cclm-2019-1001.

  • GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.

    Hauffe R, Stein V, Chudoba C, Flore T, Rath M, Ritter K, Schell M, Wardelmann K, Deubel S, Kopp JF, Schwarz M, Kappert K, Blüher M, Schwerdtle T, Kipp AP, Kleinridders A. JCI Insight. 2020 Jun 4;5(11):e136283. doi: 10.1172/jci.insight.136283.

  • Consolidation of clinical microbiology laboratories and introduction of transformative technologies

    Vandenberg, O., G.Durand, M.Hallin, A.Diefenbach, V.Gant, P.Murray, Z.Kozlakidis, and A.van Belkum. 2020. Clin Microbiol Rev. 33:e00057-19.

  • NK Cell Development in Times of Innate Lymphoid Cell Diversity

    Stokic-Trtica V, A.Diefenbach*, and C.S.N.Klose*. Front Immunol. 2020. 11:813. Published 2020 Jul 8. doi:10.3389/fimmu.2020.00813 (*Corresponding Author)

  • Innate lymphoid cell-epithelial cell modules sustain intestinal homeostasis

    Diefenbach, A., S.Gnafakis, and O.Shomrat. 2020. Immunity. 52:452-463.

  • Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

    Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R, Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J, Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL, Rosenstiel P; HCA Lung Biological Network; Deutsche COVID-19 OMICS Initiative (DeCOI). 2020. Immunity. 53:1296-1314.

  • NK Cells Regulate CD8+ T Cell Mediated Autoimmunity

    Lang, P.A., S.Q.Crome, H.C.Xu, K.S.Lang, L.Chapatte, E.K. Deenick, M.Grusdat, A.A.Pandyra, V.I.Pozdeev, R.Wang, T.A. W.Holderried, H.Cantor, A.Diefenbach, A.R.Elford, D.R.McIlwain, M.Recher, D.Häussinger, T.W.Mak, and P.S.Ohashi. 2020. Frontiers in Cellular and Infection Microbiology. doi: 0.3389/fcimb.2020.00036

  • hirty years of VRE in Germany – “expect the unexpected“: The view from the National Reference Centre for Staphylococci and Enterococci

    Werner G, Neumann B, Weber RE, Kresken M, Wendt C, Bender JK; VRE study group. 2020. TDrug Resist Updat. 53:100732.

  • c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells

    Tizian, C., A.Lahmann, O.Hölsken, C.Cosovanu, M.Kofoed-Branzk, F.Heinrich, M.F.Mashreghi, A.Kruglov, A.Diefenbach, and C.Neumann. 2020. eLife. 9:e56774

  • Microbiota-induced tonic type I interferons instruct a poised basal state of dendritic cells. Cell

    Schaupp L, S.Muth, L.Rogell, M.Kofoed-Branzk, F.Melchior, S.Lienenklaus, S.C.Ganal-Vonarburg, M.Klein, F.Guendel, T.Hain, K.Schütze, U.Grundmann, V.Schmitt, M.Dorsch, J.Spanier, P.Tegtmeyer, T.Schwanz, S.Jäckel, C.Reinhardt, T.Bopp, S.Danckwardt, K.Mahnke, G.A.Heinz, M.F.Mashreghi, P.Durek, U.Kalinke, O.Kretz, T.B.Huber, S.Weiss, C.Wilhelm, A.J.Macpherson, H.Schild, A.Diefenbach1,*, H.C.Probst*. 2020. 181:1080-1096. 1Lead Senior Author; *equal contribution.

  • Group 3 innate lymphoid cells program a distinct subset of IL-22BP-producing dendritic cells demarcating solitary intestinal lymphoid tissues

    Guendel, F., M.Kofoed-Branzk, K.Gronke, C.Tizian, M.Witkowski, H-W.Cheng, G.A.Heinz, F.Heinrich, P.Durek, P.S.Norris, C.F.Ware, C.Ruedl, S.Herold, K.Pfeffer, T.Hehlgans, A.Waisman, B.Becher, A.D.Giannou S.Brachs, K.Ebert, Y.Tanriver, B.Ludewig, M-F.Mashreghi, A.A.Kruglov, and A.Diefenbach. 2020. Immunity. 53:1015-1032.

  • Daratumumab treatment for therapy-refractoryanti-CASPR2 encephalitis

    Scheibe F, Ostendorf L, Reincke SM, Prüss H, von Brünneck AC, Köhnlein M,Alexander T, Meisel C, Meisel A. J Neurol. 2020 Feb;267(2):317-323. doi:10.1007/s00415-019-09585-6. Epub 2019 Oct 19. PMID: 31630242.

  • T Cell Impairment Is Predictive for a Severe Clinical Course in NEMODeficiency

    Heller S, Kölsch U, Magg T, Krüger R, Scheuern A, Schneider H, Eichinger A,Wahn V, Unterwalder N, Lorenz M, Schwarz K, Meisel C, Schulz A, Hauck F, vonBernuth H. J Clin Immunol. 2020 Apr;40(3):421-434. doi:10.1007/s10875-019-00728-y. Epub 2020 Jan 21. PMID: 31965418.

  • Immune biomarker-basedenrichment in sepsis trials

    Spinetti T, Meisel C, von Gunten S, Schefold JC. Crit Care. 2020 Feb 19;24(1):58. doi:10.1186/s13054-020-2774-1. PMID: 32075672; PMCID: PMC7029545.

  • Inflammatory and stress markers predicting pneumonia, outcome, and etiology inpatients with stroke: Biomarkers for predicting pneumonia, functional outcome,and death after stroke

    Hotter B, Hoffmann S, Ulm L, Montaner J, Bustamante A, Meisel C, Meisel A. Neurol Neuroimmunol Neuroinflamm. 2020 Feb 25;7(3):e692.doi: 10.1212/NXI.0000000000000692. PMID: 32098866; PMCID: PMC7051196.

  • Acute nicotine administration stimulatesciliary activity via α3β4 nAChR in the mouse trachea

    Perniss A, Latz A, Boseva I, Papadakis T, Dames C, Meisel C, Meisel A,Scholze P, Kummer W, Krasteva-Christ G. Int Immunopharmacol. 2020 Jul;84:106496. doi: 10.1016/j.intimp.2020.106496. Epub 2020 Apr 15. PMID:32304995.

  • Analysis of solubleinterleukin-2 receptor as CSF biomarker for neurosarcoidosis

    Otto C, Wengert O, Unterwalder N, Meisel C, Ruprecht K. NeurolNeuroimmunol Neuroinflamm. 2020 May 11;7(4):e725. doi:10.1212/NXI.0000000000000725. PMID: 32393650; PMCID: PMC7238895.

  • Impact of Key Nicotinic AChR Subunits on Post-Stroke Pneumococcal Pneumonia

    Jagdmann S, Dames C, Berchtold D, Winek K, Weitbrecht L, Meisel A, Meisel C. Vaccines (Basel). 2020 May 28;8(2):253. doi: 10.3390/vaccines8020253. PMID:32481512; PMCID: PMC7349987.

  • Presence of anti-neuronal antibodies in children with neurologicaldisorders beyond encephalitis

    Nikolaus M, Meisel C, Kreye J, Prüss H, Reindl M, Kaindl AM, Schuelke M,Knierim E. Eur J Paediatr Neurol. 2020 Sep;28:159-166. doi:10.1016/j.ejpn.2020.07.004. Epub 2020 Jul 30. PMID: 32807683.

  • CD70Deficiency Associated With Chronic Epstein-Barr Virus Infection, Recurrent Airway Infections and Severe Gingivitis in a 24-Year-Old Woman

    Krüger R, Martin E, Dmytrus J, Feiterna-Sperling C, Meisel C, Unterwalder N,Kölsch U, Wahn V, Hofmann J, Korn P, Latour S, Boztug K, von Bernuth H. Front Immunol. 2020 Aug 4;11:1593. doi: 10.3389/fimmu.2020.01593. PMID: 32849540; PMCID:PMC7417345.

    zur Publikation
  • SIGLEC1 (CD169) is a sensitive biomarker for thedeterioration of the clinical course in childhood systemic lupus erythematosus

    Stuckrad SLV, Klotsche J, Biesen R, Lieber M, Thumfart J, Meisel C,Unterwalder N, Kallinich T. Lupus. 2020 Dec;29(14):1914-1925. doi: 10.1177/0961203320965699. Epub 2020 Oct20. PMID: 33081587; PMCID: PMC7684796.

    zur Publikation
  • SIGLEC1 (CD169) as a potential diagnostical screening marker for monogenic interferonopathies

    Orak B, Ngoumou G, Ebstein F, Zieba B, Goetzke CC, Knierim E, Kaindl AM, Panzer A, Theophil M, Berns M, Krüger E, Meisel C, Unterwalder N, Kallinich T. Pediatr Allergy Immunol. 2020 Oct 25. doi:10.1111/pai.13400. Epub ahead of print. PMID: 33099809.

  • A case of neonatal onsetmultisystem inflammatory disease supporting a role of interleukin-1β in moyamoyasyndrome

    Wohlrab F, Bauknecht C, Meisel C, Dreier JP. Neurol Neuroimmunol Neuroinflamm. 2020 Oct 27;8(1):e1-3. doi:10.1212/NXI.0000000000000910. PMID: 33109682.

  • Myositis-specific autoantibodies and their associated phenotypes in juveniledermatomyositis: data from a German cohort

    Horn S, Minden K, Speth F, Schwarz T, Dressler F, Grösch N, Haas JP, Hinze C,Horneff G, Hospach A, Kallinich T, Klotsche J, Köstner K, Meisel C, Niewerth M,Oommen PT, Schütz C, Weller-Heinemann F, Unterwalder N, Sengler C. Clin Exp Rheumatol. 2020 Oct 29.PMID: 33124555.

  • Newborn Screening for SCID and Other SeverePrimary Immunodeficiency in the Polish-German Transborder Area: Experience From the First 14 Months of Collaboration

    Giżewska M, Durda K, Winter T, Ostrowska I, Ołtarzewski M, Klein J,Blankenstein O, Romanowska H, Krzywińska-Zdeb E, Patalan MF, Bartkowiak E,Szczerba N, Seiberling S, Birkenfeld B, Nauck M, von Bernuth H, Meisel C,Bernatowska EA, Walczak M, Pac M. Front Immunol. 2020 Oct 16;11:1948. doi:10.3389/fimmu.2020.01948. PMID: 33178177; PMCID: PMC7596351.

  • Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade

    Winek K, Lobentanzer S, Nadorp B, Dubnov S, Dames C, Jagdmann S, Moshitzky G,Hotter B, Meisel C, Greenberg DS, Shifman S, Klein J, Shenhar-Tsarfaty S, MeiselA, Soreq H. Proc Natl Acad Sci U S A. 2020 Dec22;117(51):32606-32616. doi: 10.1073/pnas.2013542117. Epub 2020 Dec 7. PMID:33288717; PMCID: PMC7768686.

    zur Publikation
  • Isavuconazole for the treatment of patients with invasive fungal diseases involving the central nervous system.

    Schwartz S, Cornely OA, Hamed K, Marty FM, Maertens J, Rahav G, Herbrecht R, Heinz WJ. Med Mycol. 2020 Jun 1;58(4):417-424. doi: 10.1093/mmy/myz103. PMID: 31613363 Free PMC article.

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  • Treatment of invasive fungal diseases in cancer patients-Revised 2019 Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO).

    Ruhnke M, Cornely OA, Schmidt-Hieber M, Alakel N, Boell B, Buchheidt D, Christopeit M, Hasenkamp J, Heinz WJ, Hentrich M, Karthaus M, Koldehoff M, Maschmeyer G, Panse J, Penack O, Schleicher J, Teschner D, Ullmann AJ, Vehreschild M, von Lilienfeld-Toal M, Weissinger F, Schwartz S. Mycoses. 2020 Jul;63(7):653-682. doi: 10.1111/myc.13082. Epub 2020 May 12. PMID: 32236989 The choice of the most appropriate antifungal treatment (AFT) depends on the fungal species suspected or identified, the patient’s risk factors (eg length and depth of granulocytopenia) and the expected side effects. …

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  • The role of bosutinib in the treatment of chronic myeloid leukemia.

    Gambacorti-Passerini C, le Coutre P, Piazza R. Future Oncol. 2020 Jan;16(2):4395-4408. doi: 10.2217/fon-2019-0555. Epub 2019 Dec 13. PMID: 31833784 Free article. Review.

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  • Single-cell analysis based dissection of clonality in myelofibrosis.

    Mylonas E, Yoshida K, Frick M, Hoyer K, Christen F, Kaeda J, Obenaus M, Noerenberg D, Hennch C, Chan W, Ochi Y, Shiraishi Y, Shiozawa Y, Zenz T, Oakes CC, Sawitzki B, Schwarz M, Bullinger L, le Coutre P, Rose-Zerilli MJJ, Ogawa S, Damm F. Nat Commun. 2020 Jan 7;11(1):73. doi: 10.1038/s41467-019-13892-x. PMID: 31911629 Free PMC article.

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  • Primary analysis of JUMP, a phase 3b, expanded-access study evaluating the safety and efficacy of ruxolitinib in patients with myelofibrosis, including those with low platelet counts.

    Al-Ali HK, Griesshammer M, Foltz L, Palumbo GA, Martino B, Palandri F, Liberati AM, le Coutre P, García-Hernández C, Zaritskey A, Tavares R, Gupta V, Raanani P, Giraldo P, Hänel M, Damiani D, Sacha T, Bouard C, Paley C, Tiwari R, Mannelli F, Vannucchi AM. Br J Haematol. 2020 Jun;189(5):888-903. doi: 10.1111/bjh.16462. Epub 2020 Feb 4. PMID: 32017044 Clinical Trial.

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  • High-risk additional chromosomal abnormalities at low blast counts herald death by CML.

    Hehlmann R, Voskanyan A, Lauseker M, Pfirrmann M, Kalmanti L, Rinaldetti S, Kohlbrenner K, Haferlach C, Schlegelberger B, Fabarius A, Seifarth W, Spieß B, Wuchter P, Krause S, Kolb HJ, Neubauer A, Hossfeld DK, Nerl C, Gratwohl A, Baerlocher GM, Burchert A, Brümmendorf TH, Hasford J, Hochhaus A, Saußele S, Baccarani M; SAKK and the German CML Study Group. Leukemia. 2020 Aug;34(8):2074-2086. doi: 10.1038/s41375-020-0826-9. Epub 2020 May 7. PMID: 32382082 Free PMC article.

    zur Publikation
  • Increased tumor burden in patients with chronic myeloid leukemia after 36 months of imatinib discontinuation.

    Diral E, Mori S, Antolini L, Abruzzese E, Le Coutre P, Martino B, Pungolino E, Elena C, Bergamaschi M, Assouline S, Di Bona E, Gozzini A, Andrade-Campos M, Stagno F, Iurlo A, Pirola A, Fontana D, Petiti J, Bonanomi ML, Crivori P, Piazza R, Fava C, Gambacorti-Passerini C. Blood. 2020 Nov 5;136(19):2237-2240. doi: 10.1182/blood.2019004371. PMID: 32518953 No abstract available.

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  • Bosutinib for pretreated patients with chronic phase chronic myeloid leukemia: primary results of the phase 4 BYOND study.

    Hochhaus A, Gambacorti-Passerini C, Abboud C, Gjertsen BT, Brümmendorf TH, Smith BD, Ernst T, Giraldo-Castellano P, Olsson-Strömberg U, Saussele S, Bardy-Bouxin N, Viqueira A, Leip E, Russell-Smith TA, Leone J, Rosti G, Watts J, Giles FJ; BYOND Study Investigators. Leukemia. 2020 Aug;34(8):2125-2137. doi: 10.1038/s41375-020-0915-9. Epub 2020 Jun 22. PMID: 32572189 Free PMC article. Clinical Trial.

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  • Early molecular response in East African Philadelphia chromosome-positive chronic myeloid leukaemia patients treated with Imatinib and barriers to access treatment.

    Henke O, Mapendo PJ, Mkwizu EW, le Coutre P. Ecancermedicalscience. 2020 Aug 18;14:1089. doi: 10.3332/ecancer.2020.1089. eCollection 2020. PMID: 33014131 Free PMC article.

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  • Combination therapy with Olaratumab/doxorubicin in advanced or metastatic soft tissue sarcoma -a single-Centre experience.

    Striefler JK, Brandes F, Baur A, Pfitzner BM, Kaul D, Rau D, Dörr A, Schmiester M, Koulaxouzidis G, Bullinger L, Märdian S, Flörcken A. BMC Cancer. 2020 Jan 29;20(1):68. doi: 10.1186/s12885-020-6551-y. PMID: 31996176 Free PMC article.

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  • Specific T-cell immune responses against colony-forming cells including leukemic progenitor cells of AML patients were increased by immune checkpoint inhibition.

    Greiner J, Götz M, Hofmann S, Schrezenmeier H, Wiesneth M, Bullinger L, Döhner H, Schneider V. Cancer Immunol Immunother. 2020 Apr;69(4):629-640. doi: 10.1007/s00262-020-02490-2. Epub 2020 Feb 4. PMID: 32020256

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  • Single-cell analysis based dissection of clonality in myelofibrosis.

    Mylonas E, Yoshida K, Frick M, Hoyer K, Christen F, Kaeda J, Obenaus M, Noerenberg D, Hennch C, Chan W, Ochi Y, Shiraishi Y, Shiozawa Y, Zenz T, Oakes CC, Sawitzki B, Schwarz M, Bullinger L, le Coutre P, Rose-Zerilli MJJ, Ogawa S, Damm F. Nat Commun. 2020 Jan 7;11(1):73. doi: 10.1038/s41467-019-13892-x. PMID: 31911629 Free PMC article.

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  • Functional Classification of TP53 Mutations in Acute Myeloid Leukemia.

    Dutta S, Pregartner G, Rücker FG, Heitzer E, Zebisch A, Bullinger L, Berghold A, Döhner K, Sill H. Cancers (Basel). 2020 Mar 10;12(3):637. doi: 10.3390/cancers12030637. PMID: 32164171 Free PMC article.

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  • Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax.

    Tausch E, Schneider C, Robrecht S, Zhang C, Dolnik A, Bloehdorn J, Bahlo J, Al-Sawaf O, Ritgen M, Fink AM, Eichhorst B, Kreuzer KA, Tandon M, Humphrey K, Jiang Y, Schary W, Bullinger L, Mertens D, Lurà MP, Kneba M, Döhner H, Fischer K, Hallek M, Stilgenbauer S. Blood. 2020 Jun 25;135(26):2402-2412. doi: 10.1182/blood.2019004492. PMID: 32206772

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  • Netboost: Boosting-supported Network Analysis Improves High-Dimensional Omics Prediction in Acute Myeloid Leukemia and Huntington’s Disease.

    Schlosser P, Knaus J, Schmutz M, Dohner K, Plass C, Bullinger L, Claus R, Binder H, Lubbert M, Schumacher M. IEEE/ACM Trans Comput Biol Bioinform. 2020 May 3;PP. doi: 10.1109/TCBB.2020.2983010. Online ahead of print. PMID: 32365034

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  • Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.

    Yusuf RZ, Saez B, Sharda A, van Gastel N, Yu VWC, Baryawno N, Scadden EW, Acharya S, Chattophadhyay S, Huang C, Viswanathan V, S’aulis D, Cobert J, Sykes DB, Keibler MA, Das S, Hutchinson JN, Churchill M, Mukherjee S, Lee D, Mercier F, Doench J, Bullinger L, Logan DJ, Schreiber S, Stephanopoulos G, Rizzo WB, Scadden DT. Blood. 2020 Sep 10;136(11):1303-1316. doi: 10.1182/blood.2019001808. PMID: 32458004

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  • Core outcome set measurement for future clinical trials in acute myeloid leukemia: the HARMONY study protocol using a multi-stakeholder consensus-based Delphi process and a final consensus meeting.

    Lang KM, Harrison KL, Williamson PR, Huntly BJP, Ossenkoppele G, Geissler J, Bereczky T, Hernández-Rivas JM, Chevrou-Séverac H, Goodbody R, Schulze-Rath R, Bullinger L. Trials. 2020 May 27;21(1):437. doi: 10.1186/s13063-020-04384-1. PMID: 32460828 Free PMC article.

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  • Monosomal karyotype and chromosome 17p loss or TP53 mutations in decitabine-treated patients with acute myeloid leukemia.

    Becker H, Pfeifer D, Ihorst G, Pantic M, Wehrle J, Rüter BH, Bullinger L, Hackanson B, Germing U, Kuendgen A, Platzbecker U, Döhner K, Ganser A, Hagemeijer A, Wijermans PW, Döhner H, Duyster J, Lübbert M. Ann Hematol. 2020 Jul;99(7):1551-1560. doi: 10.1007/s00277-020-04082-7. Epub 2020 Jun 6. PMID: 32504186 Free PMC article. Clinical Trial.

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  • Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells.

    Raffel S, Klimmeck D, Falcone M, Demir A, Pouya A, Zeisberger P, Lutz C, Tinelli M, Bischel O, Bullinger L, Thiede C, Flörcken A, Westermann J, Ehninger G, Ho AD, Müller-Tidow C, Gu Z, Herrmann C, Krijgsveld J, Trumpp A, Hansson J. Blood. 2020 Sep 24;136(13):1507-1519. doi: 10.1182/blood.2019003654. PMID: 32556243

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  • Endothelial damage and dysfunction in acute graft-versus-host disease.

    Cordes S, Mokhtari Z, Bartosova M, Mertlitz S, Riesner K, Shi Y, Mengwasser J, Kalupa M, McGeary A, Schleifenbaum J, Schrezenmeier J, Bullinger L, Diaz-Ricart M, Palomo M, Carrreras E, Beutel G, Schmitt CP, Beilhack A, Penack O. Haematologica. 2020 Jul 16. doi: 10.3324/haematol.2020.253716. Online ahead of print. PMID: 32675225

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  • Survival differences and associated molecular signatures of DNMT3A-mutant acute myeloid leukemia patients.

    Lauber C, Correia N, Trumpp A, Rieger MA, Dolnik A, Bullinger L, Roeder I, Seifert M. Sci Rep. 2020 Jul 29;10(1):12761. doi: 10.1038/s41598-020-69691-8. PMID: 32728112 Free PMC article.

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  • A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial.

    Janssen M, Schäkel U, Djuka Fokou C, Krisam J, Stermann J, Kriegsmann K, Haberbosch I, Novotny JP, Weber S, Vehreschild M, Bornhäuser M, Bullinger L, Schmitt M, Liebregts T, Dreger P, Lorenz HM, Plaszczyca A, Bartenschlager R, Müller B, Kräusslich HG, Halama N, Jäger D, Schlenk RF, Leo A, Meuer S, Weigand MA, Motsch J, Merle U, Denkinger CM, Müller-Tidow C. Trials. 2020 Oct 6;21(1):828. doi: 10.1186/s13063-020-04735-y. PMID: 33023671 Free PMC article.

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  • The long non-coding RNA Cancer Susceptibility 15 (CASC15) is induced by isocitrate dehydrogenase (IDH) mutations and maintains an immature phenotype in adult acute myeloid leukemia.

    Grasedieck S, Ruess C, Krowiorz K, Lux S, Pochert N, Schwarzer A, Klusmann JH, Jongen-Lavrencic M, Herold T, Bullinger L, Pollack JR, Rouhi A, Kuchenbauer F. Haematologica. 2020 Sep 1;105(9):e448-453. doi: 10.3324/haematol.2019.235291. PMID: 33054061 Free PMC article. No abstract available.

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  • Transcription factor 4 (TCF4) expression predicts clinical outcome in RUNX1 mutated and translocated acute myeloid leukemia.

    In’t Hout FEM, Gerritsen M, Bullinger L, Van der Reijden BA, Huls G, Vellenga E, Jansen JH. Haematologica. 2020 Sep 1;105(9):e454-457. doi: 10.3324/haematol.2019.232827. PMID: 33054062 Free PMC article. No abstract available.

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  • Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1.

    Tausch E, Beck P, Schlenk RF, Jebaraj BJ, Dolnik A, Yosifov DY, Hillmen P, Offner F, Janssens A, Babu GK, Grosicki S, Mayer J, Panagiotidis P, McKeown A, Gupta IV, Skorupa A, Pallaud C, Bullinger L, Mertens D, Döhner H, Stilgenbauer S. Haematologica. 2020 Oct 1;105(10):2440-2447. doi: 10.3324/haematol.2019.229161. PMID: 33054084 Free PMC article.

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  • TFE3 activation in a TSC1-altered malignant PEComa: challenging the dichotomy of the underlying pathogenic mechanisms.

    Schmiester M, Dolnik A, Kornak U, Pfitzner B, Hummel M, Treue D, Hartmann A, Agaimy A, Weyerer V, Lekaj A, Brakemeier S, Peters R, Öllinger R, Märdian S, Bullinger L, Striefler JK, Flörcken A. J Pathol Clin Res. 2021 Jan;7(1):3-9. doi: 10.1002/cjp2.187. Epub 2020 Nov 12. PMID: 33180365 Free PMC article.

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  • Clinical outcome of older adults with acute myeloid Leukemia: An analysis of a large tertiary referral Center over two decades.

    Ihlow J, Gross S, Neuendorff NR, Busack L, Herneth A, Singh A, Schwarz M, Flörcken A, Anagnostopoulos I, Türkmen S, Burmeister T, Blau IW, Bullinger L, Westermann J. J Geriatr Oncol. 2020 Nov 19:S1879-4068(20)30493-8. doi: 10.1016/j.jgo.2020.11.001. Online ahead of print. PMID: 33223482

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  • Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas.

    Reimann M, Schrezenmeier JF, Richter-Pechanska P, Dolnik A, Hick TP, Schleich K, Cai X, Fan DNY, Lohneis P, Masswig S, Denker S, Busse A, Knittel G, Flümann R, Childs D, Childs L, Gätjens-Sanchez AM, Bullinger L, Rosenwald A, Reinhardt HC, Schmitt CA. Blood. 2020 Nov 24:blood.2020005244. doi: 10.1182/blood.2020005244. Online ahead of print. PMID: 33232972

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  • Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.

    Jayavelu AK, Schnöder TM, Perner F, Herzog C, Meiler A, Krishnamoorthy G, Huber N, Mohr J, Edelmann-Stephan B, Austin R, Brandt S, Palandri F, Schröder N, Isermann B, Edlich F, Sinha AU, Ungelenk M, Hübner CA, Zeiser R, Rahmig S, Waskow C, Coldham I, Ernst T, Hochhaus A, Jilg S, Jost PJ, Mullally A, Bullinger L, Mertens PR, Lane SW, Mann M, Heidel FH. Nature. 2020 Dec;588(7836):157-163. doi: 10.1038/s41586-020-2968-3. Epub 2020 Nov 25. PMID: 33239784

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  • Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication.

    Jahn N, Terzer T, Sträng E, Dolnik A, Cocciardi S, Panina E, Corbacioglu A, Herzig J, Weber D, Schrade A, Götze K, Schröder T, Lübbert M, Wellnitz D, Koller E, Schlenk RF, Gaidzik VI, Paschka P, Rücker FG, Heuser M, Thol F, Ganser A, Benner A, Döhner H, Bullinger L, Döhner K. Blood Adv. 2020 Dec 22;4(24):6342-6352. doi: 10.1182/bloodadvances.2020002673. PMID: 33351131 Free PMC article.

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  • Gene Expression Profiling Predicts Sensitivity of Chronic Lymphocytic Leukemia Cells to Dasatinib.

    Blätte TJ, Machnicki MM, Glodkowska-Mrowka E, Dolnik A, Karp M, Karczmarczyk A, Giannopoulos K, Bullinger L, Stoklosa T. Hemasphere. 2020 Dec 16;5(1):e514. doi: 10.1097/HS9.0000000000000514. eCollection 2021 Jan. PMID: 33354656 Free PMC article. No abstract available.

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  • Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial.

    Kapp-Schwoerer S, Weber D, Corbacioglu A, Gaidzik VI, Paschka P, Krönke J, Theis F, Rücker FG, Teleanu MV, Panina E, Jahn N, Herzig J, Kubanek L, Schrade A, Göhring G, Fiedler W, Kindler T, Schroeder T, Mayer KT, Lübbert M, Wattad M, Götze KS, Horst HA, Koller E, Wulf G, Schleicher J, Bentz M, Krauter J, Bullinger L, Krzykalla J, Benner A, Schlenk RF, Thol F, Heuser M, Ganser A, Döhner H, Döhner K. Blood. 2020 Dec 24;136(26):3041-3050. doi: 10.1182/blood.2020005998. PMID: 33367545

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  • Clinical outcome of older adults with acute myeloid Leukemia: An analysis of a large tertiary referral Center over two decades.

    Ihlow J, Gross S, Neuendorff NR, Busack L, Herneth A, Singh A, Schwarz M, Flörcken A, Anagnostopoulos I, Türkmen S, Burmeister T, Blau IW, Bullinger L, Westermann J. J Geriatr Oncol. 2020 Nov 19

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  • Sex-specific metabolic and functional differences in human umbilical vein endothelial cells from twin pairs.

    Lorenz M, Blaschke B, Benn A, Hammer E, Witt E, Kirwan J, Fritsche-Guenther R, Gloaguen Y, Bartsch C, Vietzke A, Kramer F, Kappert K, Brunner P, Nguyen HG, Dreger H, Stangl K, Knaus P, Stangl V. Atherosclerosis. 2019 Dec;291:99-106. doi: 10.1016/j.atherosclerosis.2019.10.007.

  • Age-dependent diagnostic accuracy of clinical scoring systems and D-dimer levels in the diagnosis of pulmonary embolism with computed tomography pulmonary angiography (CTPA).

    Nagel SN, Steffen IG, Schwartz S, Hamm B, Elgeti T. Eur Radiol. 2019 Sep;29(9):4563-4571. doi: 10.1007/s00330-019-06039-5. Epub 2019 Feb 19. PMID: 30783786

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  • Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung.

    Djureinovic D, Pontén V, Landelius P, Al Sayegh S, Kappert K, Kamali-Moghaddam M, Micke P, Ståhle E. BMC Cancer. 2019 Jul 29;19(1):741. doi: 10.1186/s12885-019-5943-3.

  • Innate Lymphoid Cells and Cancer at Border Surfaces With the Environment

    Mattiola, I., and A.Diefenbach. 2019. Semin Immunol. 41:101278

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W, Benes V, Beyaert R, Blanco A, Boardman DA, Bogdan C, Borger JG, Borsellino G, Boulais PE, Bradford JA, Brenner D, Brinkman RR, Brooks AES, Busch DH, Büscher M, Bushnell TP, Calzetti F, Cameron G, Cammarata I, Cao X, Cardell SL, Casola S, Cassatella MA, Cavani A, Celada A, Chatenoud L, Chattopadhyay PK, Chow S, Christakou E, Čičin-Šain L, Clerici M, Colombo FS, Cook L, Cooke A, Cooper AM, Corbett AJ, Cosma A, Cosmi L, Coulie PG, Cumano A, Cvetkovic L, Dang VD, Dang-Heine C, Davey MS, Davies D, De Biasi S, Del Zotto G, Dela Cruz GV, Delacher M, Della Bella S, Dellabona P, Deniz G, Dessing M, Di Santo JP, Diefenbach A, et al. 2019. Eur J Immunol. 49:1457–1973.

  • Interleukin-22 protects intestinal stem cells against genotoxic stress

    Gronke, K., P.P.Hernández, J.Zimmermann, C.S.N.Klose, M.Kofoed-Branzk, F.Guendel, M.Witkowski, C.Tizian, L. Amann, F.Schumacher, H.Glatt, A.Triantafyllopoulou, and A.Diefenbach. 2019. Nature. 566:249-253.

  • Serum cytokines and theirpredictive value in pulmonary involvement of systemic sclerosis

    Becker MO, Radic M, Schmidt K, Huscher D, Riedlinger A, Michelfelder M,Meisel C, Ewert R, Burmester GR, Riemekasten G. SarcoidosisVasc Diffuse Lung Dis. 2019;36(4):274-284. doi: 10.36141/svdld.v36i4.7612. Epub2019 May 1. PMID: 32476963; PMCID: PMC7247092.

  • IL-6 PlasmaLevels Correlate With Cerebral Perfusion Deficits and Infarct Sizes in StrokePatients Without Associated Infections

    Hotter B, Hoffmann S, Ulm L, Meisel C, Fiebach JB, Meisel A. Front Neurol.2019 Feb 15;10:83. doi:10.3389/fneur.2019.00083. PMID: 30828313; PMCID: PMC6384225.

  • Screening and treatment for tuberculosis in a cohort ofunaccompanied minor refugees in Berlin, Germany

    Thee S, Krüger R, von Bernuth H, Meisel C, Kölsch U, Kirchberger V,Feiterna-Sperling C. PLoS One. 2019 May21;14(5):e0216234. doi: 10.1371/journal.pone.0216234. PMID: 31112542; PMCID:PMC6528979.

  • Killer-like receptors and GPR56progressive expression defines cytokine production of human CD4+memory T cells

    Truong KL, Schlickeiser S, Vogt K, Boës D, Stanko K, Appelt C, Streitz M,Grütz G, Stobutzki N, Meisel C, Iwert C, Tomiuk S, Polansky JK, Pascher A, BabelN, Stervbo U, Sauer I, Gerlach U, Sawitzki B. Nat Commun. 2019 May 22;10(1):2263. doi:10.1038/s41467-019-10018-1. PMID: 31118448; PMCID: PMC6531457.

  • Biomarkers of immune capacity, infection andinflammation are associated with poor outcome and mortality after stroke

    Mengel A, Ulm L, Hotter B, Harms H, Piper SK, Grittner U, Montaner J, MeiselC, Meisel A, Hoffmann S. thePREDICT study. BMC Neurol. 2019 Jul 3;19(1):148. doi: 10.1186/s12883-019-1375-6.PMID: 31269910; PMCID: PMC6607590.

  • Clinical research assessment by flowcytometry of biomarkers for infectious stratification in an EmergencyDepartment

    Bourgoin P, Soliveres T, Ahriz D, Arnoux I, Meisel C, Unterwalder N, MorangePE, Michelet P, Malergue F, Markarian T. Biomark Med. 2019 Nov;13(16):1373-1386. doi: 10.2217/bmm-2019-0214.Epub 2019 Oct 16. PMID: 31617736.

  • Diagnostic biomarkers for adult haemophagocytic lymphohistiocytosis incritically ill patients (HEMICU): a prospective observational study protocol

    Lachmann G, Knaak C, von Haefen C, Paeschke N, Meisel C, Nyvlt P, SchusterFS, Piper SK, Kruppa J, Vorderwülbecke G, Balzer F, La Rosée P, Schenk T,Unterwalder N, Kölsch U, Lachmann N, Akyüz L, Brunkhorst FM, Volk HD, Keh D,Spies C. BMJ Open. 2019 Oct 30;9(10):e032695. doi: 10.1136/bmjopen-2019-032695. PMID:31666276; PMCID: PMC6830715.

  • Current gaps in sepsis immunology: new opportunities for translational research

    Rubio I, Osuchowski MF, Shankar-Hari M, Skirecki T, Winkler MS, Lachmann G,La Rosée P, Monneret G, Venet F, Bauer M, Brunkhorst FM, Kox M, Cavaillon JM,Uhle F, Weigand MA, Flohé SB, Wiersinga WJ, Martin-Fernandez M, Almansa R,Martin-Loeches I, Torres A, Giamarellos-Bourboulis EJ, Girardis M, Cossarizza A,Netea MG, van der Poll T, Scherag A, Meisel C, Schefold JC, Bermejo-Martín JF. Lancet Infect Dis. 2019 Dec;19(12):e422-e436. doi:10.1016/S1473-3099(19)30567-5. Epub 2019 Oct 17. PMID: 31630991.

  • Underfilling of vacuum blood collection tubes leads to increased lactate dehydrogenase activity in serum and heparin plasma samples.

    Neuwinger N, Meyer Zum Büschenfelde D, Tauber R, Kappert K. Clin Chem Lab Med. 2019 Oct 30

  • Automated sample pretreatment für the analysis of synthetic cannabinoids in urine with LC-MS/MS.

    Stefan Eckelt, Simon Christopher Maaß, Carsten Mang. Poster MSACL September 2019, Salzburg.

  • A novel high pressure liquid chromatography (HPLC) – tandem mass spectrometry (MS/MS) method for the measurement of iohexol in human serum.

    Vincent Schweinsberg, Stefan Eckelt, Anna Schulz, Marcel Arlt, Marc Schumann, Markus van der Giet, Rudolf Tauber, Torsten Binscheck-Domaß, Peggy Kießling. Posterpreis der 16. Jahrestagung der DGKL (2019)

  • Pulmonary arterial remodelling by deficiency of peroxisome proliferator-activated receptor-γ in murine vascular smooth muscle cells occurs independently of obesity-related pulmonary hypertension.

    Caglayan E, Trappiel M, Behringer A, Berghausen EM, Odenthal M, Wellnhofer E, Kappert K. Respir Res. 2019 Feb 27;20(1):42. doi: 10.1186/s12931-019-1003-4.

  • PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia.

    Bastian L, Schroeder MP, Eckert C, Schlee C, Tanchez JO, Kämpf S, Wagner DL, Schulze V, Isaakidis K, Lázaro-Navarro J, Hänzelmann S, James AR, Ekici A, Burmeister T, Schwartz S, Schrappe M, Horstmann M, Vosberg S, Krebs S, Blum H, Hecht J, Greif PA, Rieger MA, Brüggemann M, Gökbuget N, Neumann M, Baldus CD. Leukemia. 2019 Aug;33(8):1895-1909. doi: 10.1038/s41375-019-0430-z. Epub 2019 Mar 6. PMID: 30842609

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  • Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures.

    Schroeder MP, Bastian L, Eckert C, Gökbuget N, James AR, Tanchez JO, Schlee C, Isaakidis K, Häupl B, Baum K, Migueles Lozano OA, Kouidri K, Pan KT, Urlaub H, Schwartz S, Burmeister T, von Stackelberg A, Hoelzer D, Pfeiffer H, Rieger MA, Göllner S, Oellerich T, Horstman M, Schrappe M, Wolf J, Kirschner-Schwabe R, Brüggemann M, Müller-Tidow C, Serve H, Neumann M, Baldus CD. Sci Rep. 2019 Mar 12;9(1):4188. doi: 10.1038/s41598-019-40786-1. PMID: 30862934 Free PMC article. Clinical Trial.

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  • Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial.

    Bastidas A, de la Serna J, El Idrissi M, Oostvogels L, Quittet P, López-Jiménez J, Vural F, Pohlreich D, Zuckerman T, Issa NC, Gaidano G, Lee JJ, Abhyankar S, Solano C, Perez de Oteyza J, Satlin MJ, Schwartz S, Campins M, Rocci A, Vallejo Llamas C, Lee DG, Tan SM, Johnston AM, Grigg A, Boeckh MJ, Campora L, Lopez-Fauqued M, Heineman TC, Stadtmauer EA, Sullivan KM; ZOE-HSCT Study Group Collaborators. JAMA. 2019 Jul 9;322(2):123-133. doi: 10.1001/jama.2019.9053. PMID: 31287523 Free PMC article. Clinical Trial.

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  • Recombinant Zoster Vaccine Significantly Reduces the Impact on Quality of Life Caused by Herpes Zoster in Adult Autologous Hematopoietic Stem Cell Transplant Recipients: A Randomized Placebo-Controlled Trial (ZOE-HSCT).

    Curran D, Matthews S, Rowley SD, Young JH, Bastidas A, Anagnostopoulos A, Barista I, Chandrasekar PH, Dickinson M, El Idrissi M, Heras I, Milliken ST, Monserrat Coll J, Navarro Matilla MB, Oostvogels L, Piątkowska-Jakubas B, Quiel D, Sabry W, Schwartz S, Selleslag DLD, Sullivan KM, Theunissen K, Yegin ZA, Yeh SP, Zaja F, Szer J; ZOE-HSCT Study group collaborators. Biol Blood Marrow Transplant. 2019 Dec;25(12):2474-2481. doi: 10.1016/j.bbmt.2019.07.036. Epub 2019 Aug 5. PMID: 31394276 Free article. Clinical Trial.

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  • Comparison of minimal residual disease levels in bone marrow and peripheral blood in adult acute lymphoblastic leukemia.

    Kotrova M, Volland A, Kehden B, Trautmann H, Ritgen M, Wäsch R, Faul C, Viardot A, Schwartz S, Baldus CD, Gökbuget N, Brüggemann M. Leukemia. 2020 Apr;34(4):1154-1157. doi: 10.1038/s41375-019-0599-1. Epub 2019 Oct 22. PMID: 31641191 No abstract available.

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  • Diagnostic Performance and Reliability of Non-Enhanced Imaging Characterization Quotients for the Differentiation of Infectious and Malignant Pulmonary Nodules in Hematological Patients Using 3T MRI.

    Nagel SN, Kim D, Wylutzki T, Steffen IG, Schwartz S, Penzkofer T, Hamm B, Elgeti T. Rofo. 2020 Apr;192(4):327-334. doi: 10.1055/a-1005-7424. Epub 2019 Oct 24. PMID: 31648350 Free article. English.

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  • Patient-reported outcomes in the phase 3 BFORE trial of bosutinib versus imatinib for newly diagnosed chronic phase chronic myeloid leukemia.

    Cortes JE, Gambacorti-Passerini C, Deininger MW, Mauro MJ, Chuah C, Kim DW, Milojkovic D, le Coutre P, Garcia-Gutierrez V, Crescenzo R, Mamolo C, Reisman A, Hochhaus A, Brümmendorf TH; BFORE Study Investigators. J Cancer Res Clin Oncol. 2019 Jun;145(6):1589-1599. doi: 10.1007/s00432-019-02894-3. Epub 2019 Apr 15. PMID: 30989330 Clinical Trial.

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  • Results from HARMONY: an open-label, multicenter, 2-arm, phase 1b, dose-finding study assessing the safety and efficacy of the oral combination of ruxolitinib and buparlisib in patients with myelofibrosis.

    Durrant ST, Nagler A, Guglielmelli P, Lavie D, le Coutre P, Gisslinger H, Chuah C, Maffioli M, Bharathy S, Dong T, Wroclawska M, Lopez JM. Haematologica. 2019 Dec;104(12):e551-e554. doi: 10.3324/haematol.2018.209965. Epub 2019 May 9. PMID: 31073072 Free PMC article. Clinical Trial. No abstract available.

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  • Cost Effectiveness of the Third-Generation Tyrosine Kinase Inhibitor (TKI) Ponatinib, vs. Second-Generation TKIs or Stem Cell Transplant, as Third-Line Treatment for Chronic-Phase Chronic Myeloid Leukemia.

    Hirt C, Iannazzo S, Chiroli S, McGarry LJ, le Coutre P, Stenke L, Dahlén T, Lipton JH. Appl Health Econ Health Policy. 2019 Aug;17(4):555-567. doi: 10.1007/s40258-019-00489-0. PMID: 31168745

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  • HLA class I-restricted T cell epitopes isolated and identified from myeloid leukemia cells.

    Nyambura LW, Muñoz AA, le Coutre P, Walden P. Sci Rep. 2019 Oct 1;9(1):14029. doi: 10.1038/s41598-019-50341-7. PMID: 31575892 Free PMC article.

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  • Ponatinib in the Treatment of Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Leukemia: Recommendations of a German Expert Consensus Panel with Focus on Cardiovascular Management.

    Saussele S, Haverkamp W, Lang F, Koschmieder S, Kiani A, Jentsch-Ullrich K, Stegelmann F, Pfeifer H, La Rosée P, Goekbuget N, Rieger C, Waller CF, Franke GN, le Coutre P, Kirchmair R, Junghanss C. Acta Haematol. 2020;143(3):217-231. doi: 10.1159/000501927. Epub 2019 Oct 7. PMID: 31590170 Free PMC article. Review.

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  • Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure.

    Hughes TP, Mauro MJ, Cortes JE, Minami H, Rea D, DeAngelo DJ, Breccia M, Goh YT, Talpaz M, Hochhaus A, le Coutre P, Ottmann O, Heinrich MC, Steegmann JL, Deininger MWN, Janssen JJWM, Mahon FX, Minami Y, Yeung D, Ross DM, Tallman MS, Park JH, Druker BJ, Hynds D, Duan Y, Meille C, Hourcade-Potelleret F, Vanasse KG, Lang F, Kim DW. N Engl J Med. 2019 Dec 12;381(24):2315-2326. doi: 10.1056/NEJMoa1902328. PMID: 31826340 Free PMC article. Clinical Trial.

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  • A phase I trial investigating the Aurora B kinase inhibitor BI 811283 in combination with cytarabine in patients with acute myeloid leukaemia.

    Döhner H, Müller-Tidow C, Lübbert M, Fiedler W, Krämer A, Westermann J, Bug G, Schlenk RF, Krug U, Goeldner RG, Hilbert J, Taube T, Ottmann OG. Br J Haematol. 2019 May;185(3):583-587. doi: 10.1111/bjh.15563. Epub 2018 Nov 19. PMID: 30450591 Clinical Trial. No abstract available.

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  • Randomized phase-II trial evaluating induction therapy with idarubicin and etoposide plus sequential or concurrent azacitidine and maintenance therapy with azacitidine.

    Schlenk RF, Weber D, Herr W, Wulf G, Salih HR, Derigs HG, Kuendgen A, Ringhoffer M, Hertenstein B, Martens UM, Grießhammer M, Bernhard H, Krauter J, Girschikofsky M, Wolf D, Lange E, Westermann J, Koller E, Kremers S, Wattad M, Heuser M, Thol F, Göhring G, Haase D, Teleanu V, Gaidzik V, Benner A, Döhner K, Ganser A, Paschka P, Döhner H. Leukemia. 2019 Aug;33(8):1923-1933. doi: 10.1038/s41375-019-0395-y. Epub 2019 Feb 6. PMID: 30728457 Free PMC article. Clinical Trial.

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  • Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients.

    Christen F, Hoyer K, Yoshida K, Hou HA, Waldhueter N, Heuser M, Hills RK, Chan W, Hablesreiter R, Blau O, Ochi Y, Klement P, Chou WC, Blau IW, Tang JL, Zemojtel T, Shiraishi Y, Shiozawa Y, Thol F, Ganser A, Löwenberg B, Linch DC, Bullinger L, Valk PJM, Tien HF, Gale RE, Ogawa S, Damm F. Blood. 2019 Mar 7;133(10):1140-1151. doi: 10.1182/blood-2018-05-852822. Epub 2019 Jan 4. PMID: 30610028

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  • Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations.

    Jutzi JS, Basu T, Pellmann M, Kaiser S, Steinemann D, Sanders MA, Hinai ASA, Zeilemaker A, Bojtine Kovacs S, Koellerer C, Ostendorp J, Aumann K, Wang W, Raffoux E, Cassinat B, Bullinger L, Schlegelberger B, Valk PJM, Pahl HL. Blood. 2019 Apr 18;133(16):1766-1777. doi: 10.1182/blood-2018-09-875047. Epub 2019 Feb 12. PMID: 30755419 Free PMC article.

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  • IDH2 inhibition: another piece to the puzzle.

    Bullinger L. Blood. 2019 Feb 14;133(7):625-626. doi: 10.1182/blood-2018-12-891481. PMID: 30765493 No abstract available.

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  • Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial.

    Herrlinger U, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Sabel M, Hau P, Kortmann RD, Krex D, Grauer O, Goldbrunner R, Schnell O, Bähr O, Uhl M, Seidel C, Tabatabai G, Kowalski T, Ringel F, Schmidt-Graf F, Suchorska B, Brehmer S, Weyerbrock A, Renovanz M, Bullinger L, Galldiks N, Vajkoczy P, Misch M, Vatter H, Stuplich M, Schäfer N, Kebir S, Weller J, Schaub C, Stummer W, Tonn JC, Simon M, Keil VC, Nelles M, Urbach H, Coenen M, Wick W, Weller M, Fimmers R, Schmid M, Hattingen E, Pietsch T, Coch C, Glas M; Neurooncology Working Group of the German Cancer Society. Lancet. 2019 Feb 16;393(10172):678-688. doi: 10.1016/S0140-6736(18)31791-4. Epub 2019 Feb 14. PMID: 30782343 Clinical Trial.

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  • Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib.

    Böhm MJ, Marienfeld R, Jäger D, Mellert K, von Witzleben A, Brüderlein S, Wittau M, von Baer A, Schultheiss M, Mayer-Steinacker R, Rücker FG, Möller P, Bullinger L, Barth TFE. Sarcoma. 2019 Jan 21;2019:3914232. doi: 10.1155/2019/3914232. eCollection 2019. PMID: 30804704 Free PMC article.

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  • NCAM1 (CD56) promotes leukemogenesis and confers drug resistance in AML.

    Sasca D, Szybinski J, Schüler A, Shah V, Heidelberger J, Haehnel PS, Dolnik A, Kriege O, Fehr EM, Gebhardt WH, Reid G, Scholl C, Theobald M, Bullinger L, Beli P, Kindler T. Blood. 2019 May 23;133(21):2305-2319. doi: 10.1182/blood-2018-12-889725. Epub 2019 Feb 27. PMID: 30814062

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  • Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.

    Basheer F, Giotopoulos G, Meduri E, Yun H, Mazan M, Sasca D, Gallipoli P, Marando L, Gozdecka M, Asby R, Sheppard O, Dudek M, Bullinger L, Döhner H, Dillon R, Freeman S, Ottmann O, Burnett A, Russell N, Papaemmanuil E, Hills R, Campbell P, Vassiliou GS, Huntly BJP. J Exp Med. 2019 Apr 1;216(4):966-981. doi: 10.1084/jem.20181276. Epub 2019 Mar 19. PMID: 30890554 Free PMC article.

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  • Venetoclax resistance and acquired BCL2 mutations in chronic lymphocytic leukemia.

    Tausch E, Close W, Dolnik A, Bloehdorn J, Chyla B, Bullinger L, Döhner H, Mertens D, Stilgenbauer S. Haematologica. 2019 Sep;104(9):e434-e437. doi: 10.3324/haematol.2019.222588. Epub 2019 Apr 19. PMID: 31004028 Free PMC article. No abstract available.

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  • IGF1R as druggable target mediating PI3K-δ inhibitor resistance in a murine model of chronic lymphocytic leukemia.

    Scheffold A, Jebaraj BMC, Tausch E, Bloehdorn J, Ghia P, Yahiaoui A, Dolnik A, Blätte TJ, Bullinger L, Dheenadayalan RP, Li L, Schneider C, Chen SS, Chiorazzi N, Dietrich S, Seiffert M, Tannheimer S, Döhner H, Mertens D, Stilgenbauer S. Blood. 2019 Aug 8;134(6):534-547. doi: 10.1182/blood.2018881029. Epub 2019 Apr 22. PMID: 31010847

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  • New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise.

    Bohl SR, Bullinger L, Rücker FG. Int J Mol Sci. 2019 Apr 23;20(8):1983. doi: 10.3390/ijms20081983. PMID: 31018543 Free PMC article. Review.

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  • Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation.

    Cocciardi S, Dolnik A, Kapp-Schwoerer S, Rücker FG, Lux S, Blätte TJ, Skambraks S, Krönke J, Heidel FH, Schnöder TM, Corbacioglu A, Gaidzik VI, Paschka P, Teleanu V, Göhring G, Thol F, Heuser M, Ganser A, Weber D, Sträng E, Kestler HA, Döhner H, Bullinger L, Döhner K. Nat Commun. 2019 May 2;10(1):2031. doi: 10.1038/s41467-019-09745-2. PMID: 31048683 Free PMC article.

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  • Localization-associated immune phenotypes of clonally expanded tumor-infiltrating T cells and distribution of their target antigens in rectal cancer.

    Penter L, Dietze K, Ritter J, Lammoglia Cobo MF, Garmshausen J, Aigner F, Bullinger L, Hackstein H, Wienzek-Lischka S, Blankenstein T, Hummel M, Dornmair K, Hansmann L. Oncoimmunology. 2019 Mar 24;8(6):e1586409. doi: 10.1080/2162402X.2019.1586409. eCollection 2019. PMID: 31069154 Free PMC article.

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  • Cytotoxic Effects of Rabbit Anti-thymocyte Globulin Preparations on Primary Human Thymic Epithelial Cells.

    Kaebisch EM, Cho MY, Oh YS, Olfe LI, Szyska M, Becker SC, Reinke P, Volk HD, Gillissen B, Bullinger L, Thiel A, Na IK. Transplantation. 2019 Nov;103(11):2234-2244. doi: 10.1097/TP.0000000000002799. PMID: 31205263

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  • Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML.

    Jakobsen JS, Laursen LG, Schuster MB, Pundhir S, Schoof E, Ge Y, d’Altri T, Vitting-Seerup K, Rapin N, Gentil C, Jendholm J, Theilgaard-Mönch K, Reckzeh K, Bullinger L, Döhner K, Hokland P, Fitzgibbon J, Porse BT. Sci Adv. 2019 Jul 10;5(7):eaaw4304. doi: 10.1126/sciadv.aaw4304. eCollection 2019 Jul. PMID: 31309149 Free PMC article.

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  • Clinical utility of a protein-based oncopanel in patients with end-stage head and neck cancer.

    Doescher J, Weissinger SE, Schönsteiner SS, Lisson C, Bullinger L, Barth TF, Leithäuser F, Mueller-Richter U, Laban S, Hoffmann TK, Möller P, Lennerz JK, Schuler PJ. Immunotherapy. 2019 Oct;11(14):1193-1203. doi: 10.2217/imt-2019-0041. Epub 2019 Aug 29. PMID: 31462115 Clinical Trial.

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  • Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML).

    Agrawal M, Schwarz P, Giaimo BD, Bedzhov I, Corbacioglu A, Weber D, Gaidzik VI, Jahn N, Rücker FG, Schroeder T, Kindler T, Wattad M, Götze K, Lübbert M, Salwender H, Ringhoffer M, Lange E, Koller E, Thol F, Heuser M, Ganser A, Bullinger L, Paschka P, Döhner H, Geiger H, Borggrefe T, Döhner K, Oswald F. Leukemia. 2020 Feb;34(2):630-634. doi: 10.1038/s41375-019-0551-4. Epub 2019 Aug 28. PMID: 31462736 Free PMC article. No abstract available.

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  • Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription.

    Edelmann J, Holzmann K, Tausch E, Saunderson EA, Jebaraj BMC, Steinbrecher D, Dolnik A, Blätte TJ, Landau DA, Saub J, Estenfelder S, Ibach S, Cymbalista F, Leblond V, Delmer A, Bahlo J, Robrecht S, Fischer K, Goede V, Bullinger L, Wu CJ, Mertens D, Ficz G, Gribben JG, Hallek M, Döhner H, Stilgenbauer S. Haematologica. 2020 May;105(5):1379-1390. doi: 10.3324/haematol.2019.217307. Epub 2019 Aug 29. PMID: 31467127 Free PMC article.

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  • Health-related quality of life and neurocognitive functioning with lomustine-temozolomide versus temozolomide in patients with newly diagnosed, MGMT-methylated glioblastoma (CeTeG/NOA-09): a randomised, multicentre, open-label, phase 3 trial.

    Weller J, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Hau P, Krex D, Grauer O, Goldbrunner R, Bähr O, Uhl M, Seidel C, Tabatabai G, Brehmer S, Bullinger L, Galldiks N, Schaub C, Kebir S, Stummer W, Simon M, Fimmers R, Coch C, Glas M, Herrlinger U, Schäfer N. Lancet Oncol. 2019 Oct;20(10):1444-1453. doi: 10.1016/S1470-2045(19)30502-9. Epub 2019 Sep 2. PMID: 31488360 Clinical Trial.

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  • Genotyping of circulating tumor DNA in cholangiocarcinoma reveals diagnostic and prognostic information.

    Ettrich TJ, Schwerdel D, Dolnik A, Beuter F, Blätte TJ, Schmidt SA, Stanescu-Siegmund N, Steinacker J, Marienfeld R, Kleger A, Bullinger L, Seufferlein T, Berger AW. Sci Rep. 2019 Sep 13;9(1):13261. doi: 10.1038/s41598-019-49860-0. PMID: 31519967 Free PMC article.

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  • Measurable residual disease monitoring in acute myeloid leukemia with t(8;21)(q22;q22.1): results from the AML Study Group.

    Rücker FG, Agrawal M, Corbacioglu A, Weber D, Kapp-Schwoerer S, Gaidzik VI, Jahn N, Schroeder T, Wattad M, Lübbert M, Koller E, Kindler T, Götze K, Ringhoffer M, Westermann J, Fiedler W, Horst HA, Greil R, Schroers R, Mayer K, Heinicke T, Krauter J, Schlenk RF, Thol F, Heuser M, Ganser A, Bullinger L, Paschka P, Döhner H, Döhner K. Blood. 2019 Nov 7;134(19):1608-1618. doi: 10.1182/blood.2019001425. PMID: 31554635 Free article.

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  • Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1).

    Meyer T, Jahn N, Lindner S, Röhner L, Dolnik A, Weber D, Scheffold A, Köpff S, Paschka P, Gaidzik VI, Heckl D, Wiese S, Ebert BL, Döhner H, Bullinger L, Döhner K, Krönke J. Leukemia. 2020 Feb;34(2):404-415. doi: 10.1038/s41375-019-0578-6. Epub 2019 Oct 1. PMID: 31576005 Free PMC article.

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  • Clonal hematopoiesis in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.

    Arends CM, Weiss M, Christen F, Eulenberg-Gustavus C, Rousselle A, Kettritz R, Eckardt KU, Chan W, Hoyer K, Frick M, Bullinger L, Bieringer M, Schreiber A, Damm F. Haematologica. 2020 Jun;105(6):e264-e267. doi: 10.3324/haematol.2019.223305. Epub 2019 Oct 3. PMID: 31582546 Free PMC article. No abstract available.

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  • Allogeneic hematopoietic cell transplantation improves outcome of adults with t(6;9) acute myeloid leukemia: results from an international collaborative study.

    Kayser S, Hills RK, Luskin MR, Brunner AM, Terré C, Westermann J, Menghrajani K, Shaw C, Baer MR, Elliott MA, Perl AE, Ráčil Z, Mayer J, Zak P, Szotkowski T, de Botton S, Grimwade D, Mayer K, Walter RB, Krämer A, Burnett AK, Ho AD, Platzbecker U, Thiede C, Ehninger G, Stone RM, Röllig C, Tallman MS, Estey EH, Müller-Tidow C, Russell NH, Schlenk RF, Levis MJ. Haematologica. 2020 Jan;105(1):161-169. doi: 10.3324/haematol.2018.208678. Epub 2019 Apr 19. PMID: 31004014 Free PMC article.

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  • Challenges in the systematic toxicological analysis of drugs and drugs of abuse (DoA)

    Peggy Kießling, Ludmila Mut, Christoph Köhler, Torsten Binscheck-Domaß, Thomas Gro-bosch. Poster Global Innovation Summit July 2019, Shimadzu.

  • Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia.

    James AR, Schroeder MP, Neumann M, Bastian L, Eckert C, Gökbuget N, Tanchez JO, Schlee C, Isaakidis K, Schwartz S, Burmeister T, von Stackelberg A, Rieger MA, Göllner S, Horstman M, Schrappe M, Kirschner-Schwabe R, Brüggemann M, Müller-Tidow C, Serve H, Akalin A, Baldus CD. J Hematol Oncol. 2019 Jan 14;12(1):8. doi: 10.1186/s13045-018-0692-3. PMID: 30642353 Free PMC article.

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  • Diagnosis of invasive fungal diseases in haematology and oncology: 2018 update of the recommendations of the infectious diseases working party of the German society for hematology and medical oncology (AGIHO).

    Ruhnke M, Behre G, Buchheidt D, Christopeit M, Hamprecht A, Heinz W, Heussel CP, Horger M, Kurzai O, Karthaus M, Löffler J, Maschmeyer G, Penack O, Rieger C, Rickerts V, Ritter J, Schmidt-Hieber M, Schuelper N, Schwartz S, Ullmann A, Vehreschild JJ, von Lilienfeld-Toal M, Weber T, Wolf HH. Mycoses. 2018 Nov;61(11):796-813. doi: 10.1111/myc.12838. Epub 2018 Sep 3. PMID: 30098069 Review.

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  • EAACI Allergen Immunotherapy Guidelines Group.: EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy.

    Pajno GB, Fernandez-Rivas M, Arasi S, Roberts G, Akdis CA, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, Ebisawa M, Eigenmann P, Knol E, Nadeau KC, Poulsen LK, van Ree R, Santos AF, du Toit G, Dhami S, Nurmatov U, Boloh Y, Makela M, O’Mahony L, Papadopoulos N, Sackesen C, Agache I, Angier E, Halken S, Jutel M, Lau S, Pfaar O, Ryan D, Sturm G, Varga EM, van Wijk RG, Sheikh A, Muraro A Allergy. 2018 Apr;73(4):799-815. doi: 10.1111/all.13319. Epub 2017 Dec 5.

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  • EAACI guidelines on allergen immunotherapy: Executive Statement.

    Muraro A, Roberts G, Halken S, Agache I, Angier E, Fernandez-Rivas M, Gerth van Wijk R, Jutel M, Lau S, Pajno G, Pfaar O, Ryan D, Sturm GJ, van Ree R, Varga EM, Bachert C, Calderon M, Canonica GW, Durham SR, Malling HJ, Wahn U, Sheikh A. Allergy. 2018 Apr;73(4):739-743. doi: 10.1111/all.13420. No abstract available.

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  • Allergy and atopy from infancy to adulthood: Messages from the German birth cohort MAS.

    Lau S, Matricardi PM, Wahn U, Lee YA, Keil T. Ann Allergy Asthma Immunol. 2018 May 25. pii: S1081-1206(18)30378-8. doi: 10.1016/j.anai.2018.05.012. [Epub ahead of print] Review.

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  • Evaluation of food allergy candidate loci in the Genetics of Food Allergy study.

    Marenholz I, Grosche S, Rüschendorf F, Kalb B, Blumchen K, Schlags R, Harandi N, Price M, Hansen G, Seidenberg J, Yürek S, Homuth G, Schmidt CO, Nöthen MM, Hubner N, Niggemann B, Beyer K, Lee YA.: J Allergy Clin Immunol. 2018 Jun 30. pii: S0091-6749(18)30929-1. doi: 10.1016/j.jaci.2018.06.019. [Epub ahead of print] No abstract available.

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  • Hen’s egg allergen in house and bed dust is significantly increased after hen’s egg consumption-A pilot study.

    Trendelenburg V, Tschirner S, Niggemann B, Beyer K.: Allergy. 2018 Jan;73(1):261-264. doi: 10.1111/all.13303. Epub 2017 Sep 26.

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  • Acute Graft Dysfunction 17 Years After Liver Transplant: A Challenging Clinical and Histologic Manifestation of Hepatitis E.

    Hillebrandt KH, Arsenic R, Hofmann J, Eurich D, Gül S, Strücker B, Sauer IM, Pratschke J, Stockmann M, Raschzok N. Exp Clin Transplant. 2018 Jun;16(3):348-351.

  • Cell-Associated Simian Immunodeficiency Virus Accelerates Initial Virus Spread and CD4+ T-Cell Depletion in the Intestinal Mucosa.

    Allers K, Kunkel D, Hofmann J, Stahl-Hennig C, Moos V, Schneider T. J Infect Dis. 2018 Apr, 11;217(9):1421-1425.

  • Prevalence and Clinical Correlates of Chronic Hepatitis E Infection in German Renal Transplant Recipients With Elevated Liver Enzymes.

    Choi M, Hofmann J, Köhler A, Wang B, Bock CT, Schott E, Reinke P, Nickel P. Transplant Direct. 2018 Feb 2;4(2):e341.

  • Advanced Kaposi’s sarcoma in a 2-year-old child.

    Feiterna-Sperling C, Anagnostopoulos I, Hofmann J, Krüger R. Lancet Infect Dis. 2018 Mar;18(3):356.

  • Comprehensive Molecular Approach for Characterization of Hepatitis E Virus Genotype 3 Variants.

    Wang B, Harms D, Papp CP, Niendorf S, Jacobsen S, Lütgehetmann M, Pischke S, Wedermeyer H, Hofmann J, Bock CT. J Clin Microbiol. 2018, Apr 25;56(5). pii: e01686-17.

  • Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells.

    Hammer Q, Rückert T, Borst EM, Dunst J, Haubner A, Durek P, Heinrich F, Gasparoni G, Babic M, Tomic A, Pietra G, Nienen M, Blau IW, Hofmann J, Na IK, Prinz I, Koenecke C, Hemmati P, Babel N, Arnold R, Walter J, Thurley K, Mashreghi MF, Messerle M, Romagnani C. Nat Immunol. 2018 May;19(5):453-463.

  • M. Proteinuria and the Clinical Course of Dobrava-Belgrade Hantavirus Infection.

    Meier M, Kramer J, Jabs WJ, Nolte C, Hofmann J, Krüger DH, Lehnert H, Nitschke Nephron Extra. 2018 Feb 9;8(1):1-10.

  • Accuracy of diagnostic tests and a new algorithm for diagnosing cytomegalovirus colitis in inflammatory bowel diseases: a diagnostic study.

    Kredel LI, Mundt P, van Riesen L, Jöhrens K, Hofmann J, Loddenkemper C, Siegmund B, Preiß JC. Int J Colorectal Dis. 2018 Oct 1.

  • PD-L1/PD-L2 Upregulation: An Imperfect Viral Immune Evasion Mechanism.

    Raftery MJ, Abdelaziz MO, Hofmann J, Schönrich G. Hantavirus-Driven Front Immunol. 2018 Dec 3;9:2560.

  • Severe GABAA receptor encephalitis without seizures: A paediatric case successfully treated with early immunomodulation.

    Nikolaus M, Knierim E, Meisel C, Kreye J, Prüss H, Schnabel D, Kallinich T. Eur J Paediatr Neurol. 2018 May;22(3):558-562. doi: 10.1016/j.ejpn.2018.01.002. Epub 2018 Jan 9.

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  • Myositis-specific antibodies associated with juvenile dermatomyositis.

    Eising K, Peitz J, Unterwalder N, Meisel C, Horneff G. Z Rheumatol. 2018 Feb 6. doi: 10.1007/s00393-017-0415-0. [Epub ahead of print] German.

    zur Publikation
  • Tips and tricks in court-Practical experience from a medical viewpoint.

    Burmester GR. Z Rheumatol. 2018 Sep;77(7):587-592. doi: 10.1007/s00393-018-0490-x. Review. German.

    zur Publikation
  • Observational study and brief analysis of diagnostic criteria in relapsing polychondritis.

    Rose T, Schneider U, Bertolo M, Klotsche J, Casteleyn V, Biesen R, Burmester GR, Hiepe F. Rheumatol Int. 2018 Aug 6. doi: 10.1007/s00296-018-4121-2. [Epub ahead of print]

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  • Biomarkers and imaging for diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the BMBF consortium ArthroMark.

    Häupl T, Skapenko A, Hoppe B, Skriner K, Burkhardt H, Poddubnyy D, Ohrndorf S, Sewerin P, Mansmann U, Stuhlmüller B, Schulze-Koops H, Burmester GR. Z Rheumatol. 2018 May;77(Suppl 1):16-23. doi: 10.1007/s00393-018-0458-x. Review. German

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  • Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis.

    Weigold F, Günther J, Pfeiffenberger M, Cabral-Marques O, Siegert E, Dragun D, Philippe A, Regensburger AK, Recke A, Yu X, Petersen F, Catar R, Biesen R, Hiepe F, Burmester GR, Heidecke H, Riemekasten G. Arthritis Res Ther. 2018 Mar 22;20(1):52. doi: 10.1186/s13075-018-1545-8.

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  • Rheumatoid Arthritis. Nat Rev Dis Primers.

    Smolen JS, Aletaha D, Barton A, Burmester GR, Emery P, Firestein GS, Kavanaugh A, McInnes IB, Solomon DH, Strand V, Yamamoto K. 2018 Feb 8;4:18001. doi: 10.1038/nrdp.2018.1. Review.

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  • Scabies, Periorbital Cellulitis and Recurrent Skin Abscesses due to Panton-Valentine Leukocidin-Positive Staphylococcus aureus Mimic Hyper IgE Syndrome in an Infant.

    Krüger R, Hanitsch LG, Leistner R, Schneider-Burrus S, Hoppe PA, Steinberg S, Hauck F, von Bernuth H. Pediatr Infect Dis J. 2017 Dec;36(12):e347-e348. doi: 10.1097/INF.0000000000001788.

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  • Serum Free Light Chains in CVID-a Marker for Differential Diagnosis.

    Hanitsch LG, Sotzny F, Volk HD, Scheibenbogen C, Wittke K. J Clin Immunol. 2018 Feb;38(2):163-165. doi: 10.1007/s10875-018-0478-y. Epub 2018 Jan 20. No abstract available.

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  • Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke.

    Dames C, Winek K, Beckers Y, Engel O, Meisel A, Meisel C. J Neuroimmunol. 2018 Aug 15;321:144-149. doi: 10.1016/j.jneuroim.2018.03.005. Epub 2018 Mar 9.

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  • Development and validation of a TTR-specific copy number screening tool, and application to potentially relevant patient cohorts.

    Jahic A., Bock A., Duca F., Bonderman D., Mascherbauer J., Windhager R., Auer-Grumbach M. & Beetz C. Mol Cell Probe. 2018;41:61-63.

  • A nonstop variant in REEP1 causes peripheral neuropathy by unmasking a 3’UTR-encoded, aggregation-inducing motif.

    Bock A.S., Günther S., Mohr J., Goldberg L.V., Jahic A., Klisch C., Hübner C.A., Biskup S. & Beetz C. Hum Mutat. 2018;39(2):193-196.

  • T-cell repertoires in refractory coeliac disease.

    Ritter J., Zimmermann K., Jöhrens K., Mende S., Seegebarth A., Siegmund B., Hennig S., Todorova K., Rosenwald A., Daum S., Hummel M. & Schumann M. Gut. 2018;67(4):644-653.

  • Architectural B-cell organization in skeletal muscle identifies subtypes of dermatomyositis.

    Radke J., Koll R., Preuße C., Pehl D., Todorova K., Schönemann C., Allenbach Y., Aronica E., de Visser M., Heppner F.L., Weis J., Doostkam S., Maisonobe T., Benveniste O., Goebel H.H. & Stenzel W. Neurol Neuroimmunol Neuroinflamm. 2018;5(3):e451.

  • The effect of blood sampling and preanalytical processing on human N-glycome.

    Dědová T., Grunow D., Kappert K., Flach D., Tauber R. & Blanchard V. PLoS ONE. 2018;13(7):e0200507

  • The cytoskeleton in ‚couch potato-ism‘: Insights from a murine model of impaired actin dynamics.

    Gertz K., Uhlemann R., Foryst-Ludwig A., Barrientos R.M., Kappert K., Thöne-Reineke C., Djoufack P., Kirschbaum C., Fink K.B., Heinz A., Kintscher U., Endres M. & Kronenberg G. Exp Neurol. 2018;306:34-44.

  • QCM-D surpassing clinical standard for the dose administration of new oral anticoagulant in the patient of coagulation disorders.

    Hussain M., Wendel H.P., Schmidt K., Langer E., Körber M.K., Faul O., Northoff H., von Heymann C. & Gehring F.K. Biosens Bioelectron. 2018;104:15-20.

  • Hypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA-DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and corre-lation with inflammatory activity.

    Schwedler C., Häupl T., Kalus U., Blanchard V., Burmester G.R., Poddubnyy D. & Hoppe B. Arthritis Res Ther. 2018;20(1):44.

  • Nilotinib.

    Gresse M, Kim TD, le Coutre P. Recent Results Cancer Res. 2018;212:69-85. doi: 10.1007/978-3-319-91439-8_3. PMID: 30069625

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  • Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD.

    Schlenk RF, Weber D, Fiedler W, Salih HR, Wulf G, Salwender H, Schroeder T, Kindler T, Lübbert M, Wolf D, Westermann J, Kraemer D, Götze KS, Horst HA, Krauter J, Girschikofsky M, Ringhoffer M, Südhoff T, Held G, Derigs HG, Schroers R, Greil R, Grießhammer M, Lange E, Burchardt A, Martens U, Hertenstein B, Marretta L, Heuser M, Thol F, Gaidzik VI, Herr W, Krzykalla J, Benner A, Döhner K, Ganser A, Paschka P, Döhner H; German-Austrian AML Study Group. Blood. 2019 Feb 21;133(8):840-851. doi: 10.1182/blood-2018-08-869453. Epub 2018 Dec 18. PMID: 30563875 Clinical Trial.

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  • Measurable residual disease monitoring by NGS before allogeneic hematopoietic cell transplantation in AML.

    Thol F, Gabdoulline R, Liebich A, Klement P, Schiller J, Kandziora C, Hambach L, Stadler M, Koenecke C, Flintrop M, Pankratz M, Wichmann M, Neziri B, Büttner K, Heida B, Klesse S, Chaturvedi A, Kloos A, Göhring G, Schlegelberger B, Gaidzik VI, Bullinger L, Fiedler W, Heim A, Hamwi I, Eder M, Krauter J, Schlenk RF, Paschka P, Döhner K, Döhner H, Ganser A, Heuser M. Blood. 2018 Oct 18;132(16):1703-1713. doi: 10.1182/blood-2018-02-829911. Epub 2018 Sep 6. PMID: 30190321 Free PMC article.

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  • Circular RNAs in Cancer.

    Lux S, Bullinger L. Adv Exp Med Biol. 2018;1087:215-230. doi: 10.1007/978-981-13-1426-1_17. PMID: 30259369 Review.

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  • Cytogenetics and gene mutations influence survival in older patients with acute myeloid leukemia treated with azacitidine or conventional care.

    Döhner H, Dolnik A, Tang L, Seymour JF, Minden MD, Stone RM, Del Castillo TB, Al-Ali HK, Santini V, Vyas P, Beach CL, MacBeth KJ, Skikne BS, Songer S, Tu N, Bullinger L, Dombret H. Leukemia. 2018 Dec;32(12):2546-2557. doi: 10.1038/s41375-018-0257-z. Epub 2018 Oct 1. PMID: 30275526 Free PMC article.

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  • Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.

    Kabrani E, Chu VT, Tasouri E, Sommermann T, Baßler K, Ulas T, Zenz T, Bullinger L, Schultze JL, Rajewsky K, Sander S. Blood. 2018 Dec 20;132(25):2670-2683. doi: 10.1182/blood-2018-06-856203. Epub 2018 Oct 17. PMID: 30333121

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  • Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation.

    Jacquelin S, Straube J, Cooper L, Vu T, Song A, Bywater M, Baxter E, Heidecker M, Wackrow B, Porter A, Ling V, Green J, Austin R, Kazakoff S, Waddell N, Hesson LB, Pimanda JE, Stegelmann F, Bullinger L, Döhner K, Rampal RK, Heckl D, Hill GR, Lane SW. Blood. 2018 Dec 27;132(26):2707-2721. doi: 10.1182/blood-2018-04-846220. Epub 2018 Oct 26. PMID: 30366920 Free article.

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  • Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation.

    Frick M, Chan W, Arends CM, Hablesreiter R, Halik A, Heuser M, Michonneau D, Blau O, Hoyer K, Christen F, Galan-Sousa J, Noerenberg D, Wais V, Stadler M, Yoshida K, Schetelig J, Schuler E, Thol F, Clappier E, Christopeit M, Ayuk F, Bornhäuser M, Blau IW, Ogawa S, Zemojtel T, Gerbitz A, Wagner EM, Spriewald BM, Schrezenmeier H, Kuchenbauer F, Kobbe G, Wiesneth M, Koldehoff M, Socié G, Kroeger N, Bullinger L, Thiede C, Damm F. J Clin Oncol. 2019 Feb 10;37(5):375-385. doi: 10.1200/JCO.2018.79.2184. Epub 2018 Nov 7. PMID: 30403573

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  • Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery.

    Simonetti G, Padella A, do Valle IF, Fontana MC, Fonzi E, Bruno S, Baldazzi C, Guadagnuolo V, Manfrini M, Ferrari A, Paolini S, Papayannidis C, Marconi G, Franchini E, Zuffa E, Laginestra MA, Zanotti F, Astolfi A, Iacobucci I, Bernardi S, Sazzini M, Ficarra E, Hernandez JM, Vandenberghe P, Cools J, Bullinger L, Ottaviani E, Testoni N, Cavo M, Haferlach T, Castellani G, Remondini D, Martinelli G. Cancer. 2019 Mar 1;125(5):712-725. doi: 10.1002/cncr.31837. Epub 2018 Nov 27. PMID: 30480765 Free PMC article.

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  • Natural tolerance development in cow’s milk allergic children: IgE and IgG4 epitope binding.

    Caubet JC, Lin J, Ahrens B, Gimenez G, Bardina L, Niggemann B, Sampson HA, Beyer K. 2017 Nov;72(11):1677-1685. doi: 10.1111/all.13167. Epub 2017 Jun 9.

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  • Randomized placebo-controlled trial of hen’s egg consumption for primary prevention in infants.

    Bellach J, Schwarz V, Ahrens B, Trendelenburg V, Aksünger Ö, Kalb B, Niggemann B, Keil T, Beyer K. J Allgergy Clin Immunol. 2017 May;139(5):1591-1599.e2. doi: 10.1016/j.jaci.2016.06.045. Epub 2016 Aug 12.

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  • Ana o 3-specific IgE is a good predictor for clinically relevant cashew allergy in children.

    Lange L, Lasota L, Finger A, Vlajnic D, Büsing S, Meister J, Broekaert I, Pfannenstiel C, Friedrichs F, Price M, Trendelenburg V, Niggemann B, Beyer K. Allergy. 2017 Apr;72(4):598-603. doi: 10.1111/all.13050. Epub 2016 Nov 17.

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  • A new framework for the documentation and interpretation of oral food challenges in population-based and clinical Research.

    Grabenhenrich LB, Reich A, Bellach J, Trendelenburg V, Sprikkelman AB, Roberts G, Grimshaw KE, Sigurdardottir S, Kowalski ML, Papadopoulos NG, Quirce S, Dubakiene R, Niggemann B, Fernández-Rivas M, Ballmer-Weber B, van Ree R, Schnadt S, Mills EN, Keil T, Beyer K. Allergy. 2017 Mar;72(3):453-461. doi: 10.1111/all.13049. Epub 2016 Oct 11.

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  • Severe anaphylaxis requiring intensive care during oral food challenge-It is not always Peanuts.

    Niggemann B, Yürek S, Beyer K. Pediatr Allergy Immunol. 2017 Mar;28(2):201-203. doi: 10.1111/pai.12676. Epub 2016 Dec 20. No abstract available.

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  • Vaccination and allergy: EAACI position paper, practical aspects.

    Nilsson L, Brockow K, Alm J, Cardona V, Caubet JC, Gomes E, Jenmalm MC, Lau S, Netterlid E, Schwarze J, Sheikh A, Storsaeter J, Skevaki C, Terreehorst I, Zanoni G. Pediatr Allergy Immunol. 2017 Nov;28(7):628-640. doi: 10.1111/pai.12762. Epub 2017 Oct 10. Review.

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  • Growth curves of „normal“ serum total IgE levels throughout childhood: A quantile analysis in a birth cohort.

    Sacco C, Perna S, Vicari D, Alfò M, Bauer CP, Hoffman U, Forster J, Zepp F, Schuster A, Wahn U, Keil T, Lau S, Matricardi PM. Pediatr Allergy Immunol. 2017 Sep;28(6):525-534. doi: 10.1111/pai.12738.

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  • Distribution and Activation of CD8+ T Cells in the Duodenal Mucosa before and after HIV Seroconversion.

    Allers K, Puyskens A, Epple HJ, Schürmann D, Hofmann J, Moos V, Schneider T. J Immunol. 2017 Jan 1;198(1):481-491. PubMed PMID: 27872210.

  • Seroprevalence of Cytomegalovirus Infection Among a Rural Population of Côte d’Ivoire.

    Anoh AE, Mossoun A, Akoua-Koffi C, Couacy-Hymann E, Pauly M, Leendertz SA, Kouakou N’goran E, Schubert G, Weiss S, Hofmann J, Leendertz FH, Ehlers B. Viral Immunol. 2017 Jan/Feb;30(1):54-57. PubMed PMID: 28055519.

  • European Multicenter Study on Analytical Performance of DxN Veris System HCV Assay.

    Braun P, Delgado R, Drago M, Fanti D, Fleury H, Gismondo MR, Hofmann J, Izopet J, Kühn S, Lombardi A, Marcos MA, Sauné K, O’Shea S, Pérez-Rivilla A, Ramble J, Trimoulet P, Vila J, Whittaker D, Artus A, Rhodes DW. J Clin Microbiol. 2017 Apr;55(4):1186-1192. PubMed PMID: 28151405; PubMed Central PMCID: PMC5377846.

  • Steep rise in norovirus cases and emergence of a new recombinant strain GII.P16-GII.2, Germany, winter 2016.

    Niendorf S, Jacobsen S, Faber M, Eis-Hübinger AM, Hofmann J, Zimmermann O, Höhne M, Bock CT. Euro Surveill. 2017 Jan 26;22(4). PubMed PMID: 28181902; PubMed Central PMCID: PMC5388089.

  • A European multicentre study on the comparison of HCV viral loads between VERIS HCV assay and COBAS(®) TaqMan(®) HCV Test and RealTime HCV Assay.

    Braun P, Drago M, Fanti D, Fleury H, Hofmann J, Izopet J, Kühn S, Lombardi A, Micheli V, Sauné K, Trimoulet P, Whittaker D, Artus A, Rhodes D. J Clin Virol. 2017 May;90:18-25. PubMed PMID:28319847.

  • Epstein-Barr virus antibodies in serum and DNA load in saliva are not associated with radiological or clinical disease activity in patients with early multiple sclerosis.

    Gieß RM, Pfuhl C, Behrens JR, Rasche L, Freitag E, Khalighy N, Otto C, Wuerfel J, Brandt AU, Hofmann J, Eberspächer B, Bellmann-Strobl J, Paul F, Ruprecht K. PLoS One. 2017 Apr 7;12(4):e0175279. PubMed PMID: 28388676; PubMed Central PMCID: PMC5384756.

  • European Multicenter Study on Analytical Performance of Veris HIV-1 Assay.

    Braun P, Delgado R, Drago M, Fanti D, Fleury H, Hofmann J, Izopet J, Kalus U, Lombardi A, Marcos MA, Mileto D, Sauné K, O’Shea S, Pérez-Rivilla A, Ramble J, Trimoulet P, Vila J, Whittaker D, Artus A, Rhodes DW. J Clin Microbiol. 2017 Jul;55(7):2055-2063. PubMed PMID:28424254; PubMed Central PMCID: PMC5483907.

  • Prevalence of human papillomavirus infection of the anal canal in women: A prospective analysis of high-risk populations.

    Kost BP, Hofmann J, Stoellnberger S, Bergauer F, Blankenstein T, Alba-Alejandre I, Stein A, Stuckart C, Weizsäcker K, Mylonas I, Mahner S, Gingelmaier A. Oncol Lett. 2017 Apr;13(4):2495-2501. PubMed PMID:28454426; PubMed Central PMCID: PMC5403543.

  • Identification of a Novel Hepatitis E Virus Genotype 3 Strain Isolated from a Chronic Hepatitis E Virus Infection in a Kidney Transplant Recipient in Switzerland.

    Wang B, Harms D, Hofmann J, Ciardo D, Kneubühl A, Bock CT. Genome Announc. 2017 May 18;5(20). PubMed PMID:28522709; PubMed Central PMCID: PMC5442380.

  • A European multicientre study on the comparison of HIV-1 viral loads between VERIS HIV-1 Assay and Roche COBAS® TAQMAN® HIV-1 test, Abbott RealTime HIV-1 Assay, and Siemens VERSANT HIV-1 Assay.

    Braun P, Delgado R, Drago M, Fanti D, Fleury H, Hofmann J, Izopet J, Kühn S, Lombardi A, Mancon A, Marcos MA, Mileto D, Sauné K, O’Shea S, Pérez-Rivilla A, Ramble J, Trimoulet P, Vila J, Whittaker D, Artus A, Rhodes D. J Clin Virol. 2017 Jul;92:75-82. PubMed PMID: 28599228.

  • Intrauterine therapy of cytomegalovirus infection with valganciclovir: review of the literature.

    Seidel V, Feiterna-Sperling C, Siedentopf JP, Hofmann J, Henrich W, Bührer C, Weizsäcker K. Med Microbiol Immunol. 2017 Oct;206(5):347-354. Review.PubMed PMID: 28733760.

  • Life-threatening systemic rotavirus infection after vaccination in severe combined immunodeficiency (SCID).

    Rosenfeld L, Mas Marques A, Niendorf S, Hofmann J, Gratopp A, Kühl JS, Schulte JH, von Bernuth H, Voigt S. Pediatr Allergy Immunol. 2017 Dec;28(8):841-843. PubMed PMID: 28815852.

  • Transplanting HCV-Infected Kidneys into Uninfected Recipients.

    Halleck F, Budde K, Duerr M, Staeck O, Hofmann J, Eisenberger U, Herzer K,Sterneck M, Gottlieb J, Schulz U. N Engl J Med. 2017 Sep 14;377(11):1103-4. PubMed PMID: 28902583.

  • High maternal expression of SIGLEC1 on monocytes as a surrogate marker of a type I interferon signature is a risk factor for the development of autoimmune congenital heart block.

    Lisney AR, Szelinski F, Reiter K, Burmester GR, Rose T, Dörner T. Ann Rheum Dis. 2017 Aug;76(8):1476-1480. doi: 10.1136/annrheumdis-2016-210927. Epub 2017 May 13.

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  • Type I interferon as a biomarker in autoimmunity and viral infection: a leukocyte subset-specific analysis unveils hidden diagnostic Options.

    Strauß R, Rose T, Flint SM, Klotsche J, Häupl T, Peck-Radosavljevic M, Yoshida T, Kyogoku C, Flechsig A, Becker AM, Dao KH, Radbruch A, Burmester GR, Lyons PA, Davis LS, Hiepe F, Grützkau A, Biesen R. J Mol Med (Berl). 2017 Jul;95(7):753-765. doi: 10.1007/s00109-017-1515-7. Epub 2017 Mar 29.

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  • What is the clinical significance of anti-Sm antibodies in systemic lupus erythematosus? A comparison with anti-dsDNA antibodies and C3.

    Flechsig A, Rose T, Barkhudarova F, Strauss R, Klotsche J, Dähnrich C, Schlumberger W, Enghard P, Burmester GR, Hiepe F, Biesen R. Clin Exp Rheumatol. 2017 Jul-Aug;35(4):598-606. Epub 2017 Mar 3.

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  • Mapping urinary chemokines in human lupus nephritis: Potentially redundant pathways recruit CD4+ and CD8+ T cells and macrophages.

    Klocke J, Kopetschke K, Grießbach AS, Langhans V, Humrich JY, Biesen R, Dragun D, Radbruch A, Burmester GR, Riemekasten G, Enghard P. Eur J Immunol. 2017 Jan;47(1):180-192. doi: 10.1002/eji.201646387. Epub 2016 Nov 21.

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  • Automated evaluation of ANA under real-life conditions.

    Loock CD, Egerer K, Feist E, Burmester GR. RMD Open. 2017 Apr 24;3(1):e000409. doi: 10.1136/rmdopen-2016-000409. eCollection 2017.

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  • Novel treatment strategies in rheumatoid Arthritis.

    Burmester GR, Pope JE. Lancet. 2017 Jun 10;389(10086):2338-2348. doi: 10.1016/S0140-6736(17)31491-5. Review.

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  • The Diagnosis and Treatment of Sjögren’s Syndrome.

    Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T. Dtsch Arztebl Int. 2017 May 26;114(20):354-361. doi: 10.3238/arztebl.2017.0354.

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  • Are interferon-related biomarkers advantageous for monitoring disease activity in systemic lupus erythematosus? A longitudinal benchmark study.

    Rose T, Grützkau A, Klotsche J, Enghard P, Flechsig A, Keller J, Riemekasten G, Radbruch A, Burmester GR, Dörner T, Hiepe F, Biesen R. Rheumatology (Oxford). 2017 Sep 1;56(9):1618-1626. doi: 10.1093/rheumatology/kex220.

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  • Assessment of immune organ dysfunction in critical illness: utility of innate immune response markers.

    Pfortmueller CA, Meisel C, Fux M, Schefold JC. Intensive Care Med Exp. 2017 Oct 23;5(1):49. doi: 10.1186/s40635-017-0163-0. Review.

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  • Antibiotic Prophylaxis, Immunoglobulin Substitution and Supportive Measures Prevent Infections in MECP2 Duplication Syndrome.

    Bauer M, Krüger R, Kölsch U, Unterwalder N, Meisel C, Wahn V, von Bernuth H. Pediatr Infect Dis J. 2018 May;37(5):466-468. doi: 10.1097/INF.0000000000001799.

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  • Interpreting Immune Mediator Dysbalance in Sepsis.

    Pfortmueller CA, Meisel C, Schefold JC. Crit Care Med. 2017 Oct;45(10):e1094-e1095. doi: 10.1097/CCM.0000000000002547. No abstract available.

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  • The Randomized Controlled STRAWINSKI Trial: Procalcitonin-Guided Antibiotic Therapy after Stroke.

    Ulm L, Hoffmann S, Nabavi D, Hermans M, Mackert BM, Hamilton F, Schmehl I, Jungehuelsing GJ, Montaner J, Bustamante A, Katan M, Hartmann A, Ebmeyer S, Dinter C, Wiemer JC, Hertel S, Meisel C, Anker SD, Meisel A. Front Neurol. 2017 Apr 24;8:153. doi: 10.3389/fneur.2017.00153. eCollection 2017.

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  • Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia – The PREDICT study.

    Hoffmann S, Harms H, Ulm L, Nabavi DG, Mackert BM, Schmehl I, Jungehulsing GJ, Montaner J, Bustamante A, Hermans M, Hamilton F, Göhler J, Malzahn U, Malsch C, Heuschmann PU, Meisel C, Meisel A; PREDICT Investigators. J Cereb Blood Flow Metab. 2017 Dec;37(12):3671-3682. doi: 10.1177/0271678X16671964. Epub 2016 Oct 14.

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  • Influenza Vaccination in Patients with Common Variable Immunodeficiency (CVID).

    Mieves JF, Wittke K, Freitag H, Volk HD, Scheibenbogen C, Hanitsch LG. Curr Allergy Asthma Rep. 2017 Oct 5;17(11):78. doi: 10.1007/s11882-017-0749-3. Review.

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  • IgG subclass deficiencies in children: Facts and fiction.

    Wahn V, von Bernuth H. Pediatr Allergy Immunol. 2017 Sep;28(6):521-524. doi: 10.1111/pai.12757. Epub 2017 Aug 7. Review.

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  • Life-threatening systemic rotavirus infection after vaccination in severe combined immunodeficiency (SCID).

    Rosenfeld L, Mas Marques A, Niendorf S, Hofmann J, Gratopp A, Kühl JS, Schulte JH, von Bernuth H, Voigt S. Pediatr Allergy Immunol. 2017 Dec;28(8):841-843. doi: 10.1111/pai.12771. Epub 2017 Oct 9. No abstract available.

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  • Doublet-Mediated DNA Rearrangement-A Novel and Potentially Underestimated Mecha-nism for the Formation of Recurrent Pathogenic Deletions.

    Jahic A., Hinreiner S., Emberger W., Hehr U., Zuchner S. & Beetz C. Hum Mutat. 2017;38(3):275-278.

  • Werner Reutter: A Visionary Pioneer in Molecular Glycobiology.

    Hinderlich S., Tauber R., Bertozzi C.R. & Hackenberger C.P.R. Chembiochem. 2017;18(13):1141-1145.

  • The Cell-Surface N-Glycome of Human Embryonic Stem Cells and Differentiated Hepatic Cells thereof.

    Montacir H., Freyer N., Knöspel F., Urbaniak T., Dedova T., Berger M., Damm G., Tauber R., Zeilinger K. & Blanchard V. Chembiochem. 2017;18(13):1234-1241.

  • The ascites N-glycome of epithelial ovarian cancer patients.

    Biskup K., Braicu E.I., Sehouli J., Tauber R. & Blanchard V. J Proteomics. 2017;157:33-39.

  • Reducing Macro- and Microheterogeneity of N-Glycans Enables the Crystal Structure of the Lectin and EGF-Like Domains of Human L-Selectin To Be Solved at 1.9 Å Resolution.

    Wedepohl S., Dernedde J., Vahedi-Faridi A., Tauber R., Saenger W. & Bulut H. Chembiochem. 2017;18(13):1338-1345.

  • Placental expression of sFlt-1 and PlGF in early preeclampsia vs. early IUGR vs. age-matched healthy pregnancies.

    Hoeller A., Ehrlich L., Golic M., Herse F., Perschel F.H., Siwetz M., Henrich W., Dechend R., Huppertz B. & Verlohren S. Hypertens Pregnancy. 2017;36(2):151-160.

  • PCSK9 regulates the chemokine receptor CCR2 on monocytes.

    Grune J., Meyborg H., Bezhaeva T., Kappert K., Hillmeister P., Kintscher U., Pieske B. & Stawowy P. Biochem Bioph Res Co. 2017;485(2):312-318.

  • Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia.

    Ehrlich L., Hoeller A., Golic M., Herse F., Perschel F.H., Henrich W., Dechend R., Hup-pertz B. & Verlohren S. Hypertens Pregnancy. 2017;36(2):175-185.

  • In vitro and ex vivo Measurement of Prophylactic Dabigatran Concentrations with a New Ecarin-Based Thromboelastometry Test.

    Körber M.K., Langer E., Köhr M., Wernecke K.D., Korte W. & von Heymann C. Transfus Med Hemoth. 2017;44(2):100-105.

  • High incidence of cardiac dysfunction and response to antiviral treatment in patients with chronic hepatitis C virus infection.

    Poller W., Kaya Z., Muche M., Kasner M., Skurk C., Kappert K., Tauber R., Escher F., Schul-theiss H.P., Epple H.J. & Landmesser U. Clin Res Cardiol. 2017;106(7):551-556.

  • Diagnostic performance of a high-sensitive troponin T assay and a troponin T point of care assay in the clinical routine of an Emergency Department: A clinical cohort study.

    Slagman A., von Recum J., Möckel M., Holert F., Meyer zum Büschenfelde D., Müller C. & Searle J. Int J Cardiol. 2017; 230:454-460.

  • Diagnosis of preeclampsia and fetal growth restriction with the sFlt-1/PlGF ratio: Diag-nostic accuracy of the automated immunoassay Kryptor®.

    Dröge L.A., Höller A., Ehrlich L., Verlohren S., Henrich W. & Perschel F.H. Pregnancy Hypertens. 2017;8:31-36.

  • AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice.

    Krueger F., Kappert K., Foryst-Ludwig A., Kramer F., Clemenz M., Grzesiak A., Sommerfeld M., Paul Frese J., Greiner A., Kintscher U., Unger T. & Kaschina E. Clin Sci. 2017;131(15):1989-2005.

  • Angiogenic Markers and Cardiovascular Indices in the Prediction of Hypertensive Disor-ders of Pregnancy.

    Verlohren S., Perschel F.H., Thilaganathan B., Dröge L.A., Henrich W., Busjahn A. & Khalil A. Hypertension. 2017;69(6):1192-1197.

  • Ana o 3-specific IgE is a good predictor for clinically relevant cashew allergy in children.

    Lange L, Lasota L, Finger A, Vlajnic D, Büsing S, Meister J, Brockaert I, Pfannenstiel C, Friedrichs F, Price M, Trendelenburg V, Niggemann B, Beyer K. Allergy. 2016 Sep 19. doi: 10.1111/all.13050

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  • Randomized placebo-controlled trial of hen’s egg consumption for primary prevention in infants.

    Bellach J, Schwarz V, Ahrens B, Trendelenburg V, Aksünger Ö, Kalb B, Niggemann B, Keil T, Beyer K. J Allergy Clin Immunol. 2016 Aug 12. pii: S0091-6749(16)30784-9. doi: 10.1016/j.jaci.2016.06.045.

    zur Publikation
  • Food allergy in childhood.

    Beyer K, Niggemann B. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016 Jun;59(6):732-6. doi: 10.1007/s00103-016-2353-4. German.

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  • The component-specific to total IgE ratios do not improve peanut and hazelnut allergy diagnoses.

    Grabenhenrich L, Lange L, Härtl M, Kalb B, Ziegert M, Finger A, Harandi N, Schlags R, Gappa M, Puzzo L, Stephan V, Heigele T, Büsing S, Ott H, Niggemann B, Beyer K. J Allergy Clin Immunol. 2016 Jun;137(6):1751-1760.e8. doi: 10.1016/j.jaci.2016.01.043. Epub 2016 Apr 14.

    zur Publikation
  • Wheat protein recognition pattern in tolerant and allergic children.

    Sievers S, Rawel HM, Ringel KP, Niggemann B, Beyer K. Pediatr Allergy Immunol. 2016 Mar;27(2):147-55. doi: 10.1111/pai.12502. Epub 2015 Dec 22

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  • Time for a new grading system for allergic reactions?

    Niggemann B, Beyer K. Allergy. 2016 Feb;71(2):135-6. doi: 10.1111/all.12765. Epub 2015 Sep 28.

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  • The effect of timing of antiretroviral therapy on CD4+ T-cell reconstitution in the intestine of HIV-infected patients.

    Allers K, Puyskens A, Epple HJ, Schürmann D, Hofmann J, Moos V, Schneider T. Mucosal Immunol. 2016 Jan;9(1):265-74. PubMed PMID: 26129649.

  • Brincidofovir clearance of acyclovir-resistant herpes simplex virus-1 and adenovirus infection after stem cell transplantation.

    Voigt S, Hofmann J, Edelmann A, Sauerbrei A, Kühl JS. Transpl Infect Dis. 2016 Oct;18(5):791-794. PubMed PMID: 27482652.

  • Moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells.

    Heinrich A, Haarmann H, Zahradnik S, Frenzel K, Schreiber F, Klassert TE, Heyl KA, Endres AS, Schmidtke M, Hofmann J, Slevogt H. FASEB J. 2016 Jun;30(6):2426-34. PubMed PMID: 26979086.

  • Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance.

    Fischer L, Imrich E, Sampaio KL, Hofmann J, Jahn G, Hamprecht K, Göhring K. Antiviral Res. 2016 Jul;131:1-8.PubMed PMID: 27058773.

  • Antibody producing B lineage cells invade the central nervous system predominantly at the time of and triggered by acute Epstein-Barr virus infection: A hypothesis on the origin of intrathecal immunoglobulin synthesis in multiple sclerosis.

    Otto C, Hofmann J, Ruprecht K. Med Hypotheses. 2016 Jun;91:109-13. PubMed PMID: 27142157.

  • Two-Year Follow-Up Analysis of Telaprevir-Based Antiviral Triple Therapy for HCV Recurrence in Genotype 1 Infected Liver Graft Recipients as a First Step towards Modern HCV Therapy.

    Klein F, Neuhaus R, Eurich D, Hofmann J, Bayraktar S, Pratschke J, Bahra M. Hepat Res Treat. 2016;2016:8325467. PubMed PMID: 27195149.

  • Thermal Stability of Hepatitis E Virus as Estimated by a Cell Culture Method.

    Johne R, Trojnar E, Filter M, Hofmann J. Appl Environ Microbiol. 2016 Jun 30;82(14):4225-31. PubMed PMID: 27208095.

  • High seroprevalence of antibodies against Kaposi’s sarcoma-associated herpesvirus (KSHV) among HIV-1-infected children and adolescents in a non-endemic population.

    Feiterna-Sperling C, Königs C, Notheis G, Buchholz B, Krüger R, Weizsäcker K, Eberle J, Hanhoff N, Gärtner B, Heider H, Krüger DH, Hofmann J. Med Microbiol Immunol. 2016 Oct;205(5):425-34. PubMed PMID: 27240652.

  • Acute Graft Dysfunction 17 Years After Liver Transplant: A Challenging Clinical and Histologic Manifestation of Hepatitis E.

    Hillebrandt KH, Arsenic R, Hofmann J, Eurich D, Gül S, Strücker B, Sauer IM, Pratschke J, Stockmann M, Raschzok N. Exp Clin Transplant. 2016 Jun 15.PubMed PMID: 27310664.

  • Clinical outcome of norovirus infection in renal transplant patients.

    Brakemeier S, Taxeidi SI, Dürr M, Hofmann J, Schmidt D, Bachmann F, Gaedeke J, Budde K. Clin Transplant. 2016 Oct;30(10):1283-1293. PubMed PMID:27447127.

  • High prevalence of anti-hepatitis E virus antibodies in outpatients with chronic liver disease in a university medical center in Germany.

    Schulz M, Beha D, Plehm K, Zöllner C, Hofmann J, Schott E. Eur J Gastroenterol Hepatol. 2016 Dec;28(12):1431-1436. PubMed PMID: 27552296.

  • Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi.

    Krautkrämer E, Nusshag C, Baumann A, Schäfer J, Hofmann J, Schnitzler P, Klempa B, Witkowski PT, Krüger DH, Zeier M. BMC Infect Dis. 2016 Nov 14;16(1):675. PubMed PMID: 27842513.

  • Laboratory diagnostics in rheumatology.

    Dörner T, Fleck M. Z Rheumatol. 2016 May;75(4):354-5. doi: 10.1007/s00393-016-0087-1. German. No abstract available.

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  • Effects of treatment with etanercept versus methotrexate on sleep quality, fatigue and selected immune parameters in patients with active rheumatoid Arthritis.

    Detert J, Dziurla R, Hoff P, Gaber T, Klaus P, Bastian H, Braun T, Schellmann S, Penzel T, Fietze I, Loeschmann PA, Jaehnig P, Straub RH, Burmester GR, Buttgereit F. Clin Exp Rheumatol. 2016 Sep-Oct;34(5):848-856. Epub 2016 Jun 22.

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  • Sequential high-content profiling of the IgG-autoantibody repertoire reveals novel antigens in rheumatoid Arthritis.

    Vordenbäumen S, Lueking A, Budde P, Zucht HD, Goehler H, Brinks R, Fischer-Betz R, Richter J, Bleck E, Detert J, Langer HE, Sörgel A, Burmester GR, Schulz-Knappe P, Schneider M. Arthritis Res Ther. 2016 Oct 12;18(1):235.

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  • SIGLEC1 is a biomarker of disease activity and indicates extraglandular manifestation in primary Sjögren’s Syndrome.

    Rose T, Szelinski F, Lisney A, Reiter K, Fleischer SJ, Burmester GR, Radbruch A, Hiepe F, Grützkau A, Biesen R, Dörner T. RMD Open. 2016 Dec 30;2(2):e000292. doi: 10.1136/rmdopen-2016-000292. eCollection 2016.

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  • Targeting GM-CSF in rheumatoid Arthritis.

    Avci AB, Feist E, Burmester GR. Clin Exp Rheumatol. 2016 Jul-Aug;34(4 Suppl 98):39-44. Epub 2016 Jul 21. Review.

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  • BCR-ABL-positive acute myeloid leukemia: a new entity? Analysis of clinical and molecular features.

    Neuendorff N R, Burmeister T, Dörken B, Westermann J Annaly of hematology DOI 10.1007/s00277-016-2721-z

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  • Durchflusszytometrische Immunphänotypisierung in der klinischen Diagnostik.

    Ostendorf, B N, Hansmann, L, Ludwig, w-D, Dörken, B, Ratei, R, Westermann, J. Dtsch Med Wochenschr 2016; 141: 1569–1574

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  • Cellular and humoral influenza-specific immune response upon vaccination in patients with common variable immunodeficiency and unclassified antibody deficiency.

    Hanitsch LG, Löbel M, Mieves JF, Bauer S, Babel N, Schweiger B, Wittke K, Grabowski P, Volk HD, Scheibenbogen C. Vaccine. 2016 May 5;34(21):2417-2423. doi: 10.1016/j.vaccine.2016.03.091. Epub 2016 Apr 5.

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  • Key findings to expedite the diagnosis of hyper-IgE syndromes in infants and young children.

    Hagl B, Heinz V, Schlesinger A, Spielberger BD, Sawalle-Belohradsky J, Senn-Rauh M, Magg T, Boos AC, Hönig M, Schwarz K, Dückers G, von Bernuth H, Pache C, Karitnig-Weiss C, Belohradsky BH, Frank J, Niehues T, Wahn V, Albert MH, Wollenberg A, Jansson AF, Renner ED. Pediatr Allergy Immunol. 2016 Mar;27(2):177-84. doi: 10.1111/pai.12512. Epub 2016 Jan 26.

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  • Stroke induces specific alteration of T memory compartment controlling auto-reactive CNS antigen-specific T cell responses.

    Klehmet J, Hoffmann S, Walter G, Meisel C, Meisel A. J Neurol Sci. 2016 Sep 15;368:77-83. doi: 10.1016/j.jns.2016.06.039. Epub 2016 Jun 17.

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  • EBNA1 antigen-specific CD8+ T cells in cerebrospinal fluid of patients with multiple sclerosis.

    Erdur H, Scholz V, Streitz M, Hammer M, Meisel C, Schönemann C, Wandinger KP, Rosche B. J Neuroimmunol. 2016 May 15;294:14-7. doi: 10.1016/j.jneuroim.2016.03.010. Epub 2016 Mar 19.

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  • A polymorphic Alu insertion that mediates distinct disease-associated deletions.

    Jahic A., Erichsen A.K., Deufel T., Tallaksen C.M. & Beetz C. Eur J Hum Genet. 2016;24(9):1371-4.

  • Novel Genetic, Clinical, and Pathomechanistic Insights into TFG-Associated Hereditary Spastic Paraplegia.

    Harlalka G.V., McEntagart M.E., Gupta N., Skrzypiec A.E., Mucha M.W., Chioza B.A., Simp-son M.A., Sreekantan-Nair A., Pereira A., Günther S., Jahic A., Modarres H., Moore-Barton H., Trembath R.C., Kabra M., Baple E.L., Thakur S., Patton M.A., Beetz C., Pawlak R. & Crosby A.H. Hum Mutat. 2016;37(11):1157-1161.

  • Maternal mosaicism for IDUA deletion clarifies recurrence risk in MPS I.

    1. Breen C., Mercer J., Jones S.A., Jahic A., Heptinstall L., Tylee K., Newman W.G. & Beetz C. Hum Genome Var. 2016;3:16031.

  • Transcriptome analysis of periodontitis-associated fibroblasts by CAGE sequencing identi-fied DLX5 and RUNX2 long variant as novel regulators involved in periodontitis.

    Horie M., Yamaguchi Y., Saito A., Nagase T., Lizio M., Itoh M., Kawaji H., Lassmann T., Car-ninci P., Forrest A.R.R., Hayashizaki Y., Suzutani T., Kappert K., Micke P. & Ohshima M. Sci Rep. 2016;6:33666.

  • Therapeutic Targeting of Telomerase.

    Jäger K. & Walter M. Genes-basel. 2016;7(7)

  • Structural requirements of mono- and multivalent L-selectin blocking aptamers for en-hanced receptor inhibition in vitro and in vivo.

    Riese S.B., Buscher K., Enders S., Kuehne C., Tauber R. & Dernedde J. Nanomed-Nanotechnol. 2016;12(4):901-908.

  • Preemptive Isolation Precautions of Patients at High Risk for Methicillin-Resistant Staphy-lococcus aureus in Combination With Ultrarapid Polymerase Chain Reaction Screening as an Effective Tool for Infection Control.

    Hallak G., Neuner B., Schefold J.C., Gorzelniak K., Rapsch B., Pfüller R., Stengel D., Well-mann J., Ekkernkamp A. & Walter M. Infect Cont Hosp Ep. 2016;37(12):1489-1491.

  • Pioglitazone alleviates cardiac and vascular remodelling and improves survival in mono-crotaline induced pulmonary arterial hypertension.

    Behringer A., Trappiel M., Berghausen E.M., Ten Freyhaus H., Wellnhofer E., Odenthal M., Blaschke F., Er F., Gassanov N., Rosenkranz S., Baldus S., Kappert K. & Caglayan E. N-S Arch Pharmacol. 2016;389(4):369-79.

  • Inhibition of Src homology 2 domain-containing phosphatase 1 increases insulin sensitivi-ty in high-fat diet-induced insulin-resistant mice.

    Krüger J., Wellnhofer E., Meyborg H., Stawowy P., Östman A., Kintscher U. & Kappert K. Febs Open Bio. 2016;6(3):179-89.

  • In vitro reversal of supratherapeutic rivaroxaban levels with coagulation factor concen-trates.

    Körber M.K., Langer E., Kaufner L., Sander M. & Von Heymann C. Blood Transfus. 2016;14(5):481-6.

  • Fibroblast VEGF-receptor 1 expression as molecular target in periodontitis.

    Ohshima M., Yamaguchi Y., Ambe K., Horie M., Saito A., Nagase T., Nakashima K., Ohki H., Kawai T., Abiko Y., Micke P. & Kappert K. J Clin Periodontol. 2016;43(2):128-37.

  • Delta-He, Ret-He and a New Diagnostic Plot for Differential Diagnosis and Therapy Moni-toring of Patients Suffering from Various Disease-Specific Types of Anemia.

    Weimann A., Cremer M., Hernáiz-Driever P. & Zimmermann M. Clin Lab. 2016;62(4):667-77.

  • Acute-phase glycoprotein N-glycome of ovarian cancer patients analyzed by CE-LIF.

    Weiz S., Wieczorek M., Schwedler C., Kaup M., Braicu E.I., Sehouli J., Tauber R. & Blanchard V. Electrophoresis. 2016;37(11):1461-7.

  • Activation of Peroxisome Proliferator-Activated Receptor-δ as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent Thrombosis.

    Hytönen J., Leppänen O., Braesen J.H., Schunck W.H., Mueller D., Jung F., Mrowietz C., Jastroch M., von Bergwelt-Baildon M., Kappert K., Heuser A., Drenckhahn J.D., Pieske B., Thierfelder L., Ylä-Herttuala S. & Blaschke F. Arterioscl Throm Vas. 2016;36(8):1534-48.

  • Allergen and allergy risk assessment, allergen management, and gaps in the European Food Information Regulation (FIR): Are allergic consumers adequately protected by current statutory food safety and labelling regulations?

    Reese I, Holzhauser T, Schnadt S, Dölle S, Kleine-Tebbe J, Raithel M, Worm M, Zuberbier T, Vieths S. Allergo J Int. 2015;24:180-184. Epub 2015 Sep 28.

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  • Chemokine levels in serum of children with atopic dermatitis with regard to severity and sensitization status.

    Ahrens B, Schulz G, Bellach J, Niggemann B, Beyer K. Pediatr Allergy Immunol. 2015 Nov;26(7):634-40. doi: 10.1111/pai.12431. Epub 2015 Jul 14.

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  • Detection of relevant amounts of cow’s milk protein in non-pre-packed bakery products sold as cow’s milk-free.

    Trendelenburg V, Enzian N, Bellach J, Schnadt S, Niggemann B, Beyer K. Allergy. 2015 May;70(5):591-7. doi: 10.1111/all.12588. Epub 2015 Feb 26.

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  • Predictive values of component-specific IgE for the outcome of peanut and hazelnut food challenges in children.

    Beyer K, Grabenhenrich L, Härtl M, Beder A, Kalb B, Ziegert M, Finger A, Harandi N, Schlags R, Gappa M, Puzzo L, Röblitz H, Millner-Uhlemann M, Büsing S, Ott H, Lange L, Niggemann B. Allergy. 2015 Jan;70(1):90-8. doi: 10.1111/all.12530. Epub 2014 Nov 30.

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  • Successful Treatment of Chronic Hepatitis E After an Orthotopic Liver Transplant With Ribavirin Monotherapy.

    Klein F, Neuhaus R, Hofmann J, Rudolph B, Neuhaus P, Bahra M. Exp Clin Transplant. 2015 Jun;13(3):283-6. PMID: 24779678.

  • Hantavirus-induced pathogenesis in mice with a humanized immune system.

    Kobak L, Raftery MJ, Voigt S, Kühl AA, Kilic E, Kurth A, Witkowski P, Hofmann J, Nitsche A, Schaade L, Krüger DH, Schönrich G. J Gen Virol. 2015 Jun;96(Pt 6):1258-63. PMID: 25678530.

  • Association of low serum TGF-β level in hantavirus infected patients with severe disease.

    Sadeghi M, Lahdou I, Ettinger J, Navid MH, Daniel V, Zeier M, Hofmann J, Opelz G, Schnitzler P. BMC Immunol. 2015 Apr 14;16:19. PMCID: 4399110.

  • Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors.

    van Bömmel F, Bartens A, Mysickova A, Hofmann J, Krüger DH, Berg T, Edelmann A. Hepatology. 2015 Jan;61(1):66-76. PMID: 25132147.

  • Association of serum Epstein-Barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis.

    Pfuhl C, Oechtering J, Rasche L, Gieß RM, Behrens JR, Wakonig K, Freitag E, Pache FC, Otto C, Hofmann J, Eberspächer B, Bellmann-Strobl J, Paul F, Ruprecht K. J Neuroimmunol. 2015 Aug 15;285:156-60. PMID: 26198934.

  • Does proficiency testing improve the quality of hantavirus serodiagnostics? Experiences with INSTAND EQA schemes.

    Hofmann J, Grunert HP, Donoso-Mantke O, Zeichhardt H, Kruger DH. Int J Med Microbiol. 2015, Oct;305(7):607-11. PMID: 26342877.

  • Herpes Simplex Virus Sepsis in a Young Woman with Crohn’s Disease.

    Haag LM, Hofmann J, Kredel LI, Holzem C, Kühl AA, Taube ET, Schubert S, Siegmund B, Epple HJ. J Crohns Colitis. 2015 Dec;9(12):1169-73. PMID: 26351382.

  • Rheumatische und muskuloskelettale Erkrankungen–eine wissenschaftliche und klinische Herausforderung.

    Burmester GR. Drug Res (Stuttg). 2015 Nov;65 Suppl 1:S2. doi: 10.1055/s-0035-1558059. Epub 2015 Nov 4. German. No abstract available.

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  • Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus.

    von Spee-Mayer C, Siegert E, Abdirama D, Rose A, Klaus A, Alexander T, Enghard P, Sawitzki B, Hiepe F, Radbruch A, Burmester GR, Riemekasten G, Humrich JY. Ann Rheum Dis. 2016 Jul;75(7):1407-15. doi: 10.1136/annrheumdis-2015-207776. Epub 2015 Aug 31.

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  • Restrictive IgG antibody response against mutated citrullinated vimentin predicts response to rituximab in patients with rheumatoid Arthritis.

    Lindenberg L, Spengler L, Bang H, Dorner T, Maslyanskiy AL, Lapin SV, Ilivanova EI, Martinez-Gamboa L, Bastian H, Wittenborn E, Egerer K, Burmester GR, Feist E. Arthritis Res Ther. 2015 Aug 13;17:206. doi: 10.1186/s13075-015-0717-z.

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  • The cellular signature of urinary immune cells in Lupus nephritis: new insights into potential biomarkers.

    Kopetschke K, Klocke J, Grießbach AS, Humrich JY, Biesen R, Dragun D, Burmester GR, Enghard P, Riemekasten G. Arthritis Res Ther. 2015 Apr 3;17:94. doi: 10.1186/s13075-015-0600-y.

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  • Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE.

    Humrich JY, von Spee-Mayer C, Siegert E, Alexander T, Hiepe F, Radbruch A, Burmester GR, Riemekasten G. Ann Rheum Dis. 2015 Apr;74(4):791-2. doi: 10.1136/annrheumdis-2014-206506. Epub 2015 Jan 21. No abstract available.

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  • Circadian rhythms of cellular immunity in rheumatoid arthritis: a hypothesis-generating study.

    Spies CM, Hoff P, Mazuch J, Gaber T, Maier B, Strehl C, Hahne M, Jakstadt M, Huscher D, Burmester GR, Detert J, Kramer A, Buttgereit F. Clin Exp Rheumatol. 2015 Jan-Feb;33(1):34-43. Epub 2014 Dec 22.

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  • Effects of 60-day bed rest with and without exercise on cellular and humoral immunological Parameters.

    Hoff P, Belavý DL, Huscher D, Lang A, Hahne M, Kuhlmey AK, Maschmeyer P, Armbrecht G, Fitzner R, Perschel FH, Gaber T, Burmester GR, Straub RH, Felsenberg D, Buttgereit F. Cell Mol Immunol. 2015 Jul;12(4):483-92. doi: 10.1038/cmi.2014.106. Epub 2014 Nov 10.

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  • Infectious and Immunologic Phenotype of MECP2 Duplication Syndrome.

    Bauer M, Kölsch U, Krüger R, Unterwalder N, Hameister K, Kaiser FM, Vignoli A, Rossi R, Botella MP, Budisteanu M, Rosello M, Orellana C, Tejada MI, Papuc SM, Patat O, Julia S, Touraine R, Gomes T, Wenner K, Xu X, Afenjar A, Toutain A, Philip N, Jezela-Stanek A, Gortner L, Martinez F, Echenne B, Wahn V, Meisel C, Wieczorek D, El-Chehadeh S, Van Esch H, von Bernuth H. J Clin Immunol. 2015 Feb;35(2):168-81. doi: 10.1007/s10875-015-0129-5. Epub 2015 Feb 27. PMID: 25721700

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  • In patients with defects in Toll-like and Interleukin-1 receptor (TIR)-dependent signalling septic arthritis may present like Juvenile Idiopathic Arthritis.

    Kallinich T, Kölsch U, Lieber M, Unterwalder N, Spors B, Lorenz M, Schwarz K, Meisel C, von Bernuth H. Pediatr Allergy Immunol. 2015 Apr 9. doi: 10.1111/pai.12373. [Epub ahead of print] PMID: 25865658

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  • Late-Onset Disseminated Mycobacterium avium intracellulare Complex Infection (MAC), Cerebral Toxoplasmosis and Salmonella Sepsis in a German Caucasian Patient with Unusual Anti-Interferon-Gamma IgG1 Autoantibodies.

    Hanitsch LG1, Löbel M, Müller-Redetzky H, Schürmann M, Suttorp N, Unterwalder N, Mönnich U, Meisel C, Wittke K, Volk HD, Scheibenbogen C, Kölsch U. J Clin Immunol. 2015 Apr 15. [Epub ahead of print] PMID: 25875701

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  • Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis.

    Sahin E, Brunner JS, Kral JB, Kuttke M, Hanzl L, Datler H, Paar H, Neuwinger N, Saferding V, Zinser E, Halfmann A, Soukup K, Hainzl E, Lohmeyer T, Niederreiter B, Haider T, Dohnal AM, Krönke G, Blüml S, Schabbauer G. J Immu-nol. 2015 Sep 15;195(6):2560-70

  • Modeling risk for severe adverse outcomes using angiogenic factor measurements in women with suspected preterm preeclampsia.

    Palomaki G.E., Haddow J.E., Haddow H.R.M., Salahuddin S., Geahchan C., Cerdeira A.S., Verlohren S., Perschel F.H., Horowitz G., Thadhani R., Karumanchi S.A. & Rana S. Prenatal Diag. 2015;35(4):386-93.

  • Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters.

    Hoff P., Belavý D.L., Huscher D., Lang A., Hahne M., Kuhlmey A.K., Maschmeyer P., Armbrecht G., Fitzner R., Perschel F.H., Gaber T., Burmester G.R., Straub R.H., Felsenberg D. & Buttgereit F. Cell Mol Immunol. 2015;12(4):483-92.

  • CT-proET1 predicts pulmonary hemodynamics in Scleroderma-associated pulmonary hypertension.

    Ten Freyhaus H., Dumitrescu D., Schnorbach S., Kappert K., Viethen T., Hellmich M., Hunzelmann N. & Rosenkranz S. Clin Res Cardiol. 2015;104(6):525-9.

  • Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice.

    Krüger J., Brachs S., Trappiel M., Kintscher U., Meyborg H., Welln-hofer E., Thöne-Reineke C., Stawowy P., Östman A., Birkenfeld A.L., Böhmer F.D. & Kappert K. Mol Metab. 2015;4(4):325-36.

  • Autoantikörper bei juveniler idiopathischer inflammatorischer Myopathie

    González-González J.B., Meisel C. & Unterwalder N. Arthritis Rheuma. 2015;35(03):176-182.

  • Triggers and treatment of anaphylaxis: an analysis of 4,000 cases from Germany, Austria and Switzerland.

    Worm M1, Eckermann O, Dölle S, Aberer W, Beyer K, Hawranek T, Hompes S, Koehli A, Mahler V, Nemat K, Niggemann B, Pföhler C, Rabe U, Reissig A, Rietschel E, Scherer K, Treudler R, Ruëff F Dtsch Arztebl Int. 2014 May 23;111(21):367-75. doi: 10.3238/arztebl.2014.0367. PMID: 24939374

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  • Modified oral food challenge used with sensitization biomarkers provides more real-life clinical thresholds for peanut allergy.

    Blumchen K, Beder A, Beschorner J, Ahrens F, Gruebl A, Hamelmann E5, Hansen G, Heinzmann A, Nemat K, Niggemann B, Wahn U, Beyer K. J Allergy Clin Immunol. 2014 May 13. pii: S0091-6749(14)00517-X. doi: 10.1016/j.jaci.2014.03.035. PMID: 24831438

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  • EAACI Food Allergy and Anaphylaxis Guidelines: diagnosis and management of food allergy.

    Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Beyer K, Bindslev-Jensen C, Cardona V, Dubois A, duToit G, Eigenmann P, Fernandez Rivas M, Halken S, Hickstein L, Høst A, Knol E, Lack G, Marchisotto MJ, Niggemann B, Nwaru BI, Papadopoulos NG, Poulsen LK, Santos AF, Skypala I, Schoepfer A, Van Ree R, Venter C, Worm M, Vlieg-Boerstra B, Panesar S, de Silva D, Soares-Weiser K, Sheikh A, Ballmer-Weber BK, Nilsson C, de Jong NW, Akdis CA Allergy. 2014 Jun 9. doi: 10.1111/all.12429. PMID: 24909706

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  • Parental hay fever reinforces IgE to pollen as pre-clinical biomarker of hay fever in childhood.

    Hatzler L1, Panetta V, Illi S, Hofmaier S, Rohrbach A, Hakimeh D, Bauer CP, Hoffman U, Forster J, Zepp F, Schuster A, Stock P, Wahn U, Keil T, Lau S, Matricardi PM Pediatr Allergy Immunol. 2014 Jun;25(4):366-73. doi: 10.1111/pai.12248. PMID: 24953296

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  • Predictive values of component-specific IgE for the outcome of peanut and hazelnut food challenges in children.

    Beyer K1, Grabenhenrich L, Beder A, Kalb B, Ziegert M, Finger A, Harandi N, Schlags R, Gappa M, Puzzo L, Röblitz H, Millner-Uhlemann M, Büsing S, Ott H, Lange L, Niggemann B Allergy. 2014 Oct 13. doi: 10.1111/all.12530. [Epub ahead of print] PMID: 25308885

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  • Factors augmenting allergic reactions.

    Niggemann B1, Beyer K Allergy. 2014 Dec;69(12):1582-7. doi: 10.1111/all.12532. PMID: 25306896

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  • The fraction of varicella zoster virus-specific antibodies among all intrathecally-produced antibodies discriminates between patients with varicella zoster virus reactivation and multiple sclerosis.

    Otto C, Hofmann J, Finke C, Zimmermann M, Ruprecht K. Fluids Barriers CNS. 2014 Feb 12. PMID: 24517462

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  • Combination of immunoglobulins and natural killer cells in the context of CMV and EBV infection.

    Frenzel K, Lehmann J, Krüger DH, Martin-Parras L, Uharek L, Hofmann J. Med Microbiol Immunol. 2014 Apr;203(2):115-23. PMID: 24337366.

  • Hantavirus disease in Germany due to infection with Dobrava-Belgrade virus genotype Kurkino. Clin Microbiol Infect.

    Hofmann J, Meier M, Enders M, Führer A, Ettinger J, Klempa B, Schmidt S, Ulrich RG, Kruger DH. 2014 Oct;20(10):O648-55. PMID: 24438436.

  • An ORF1-rearranged hepatitis E virus derived from a chronically infected patient efficiently replicates in cell culture.

    Johne R, Reetz J, Ulrich RG, Machnowska P, Sachsenröder J, Nickel P, Hofmann J. J Viral Hepat. 2014 Jun;21(6):447-56. PMID: 24750215.

  • Parvovirus B19 genotype 2 in blood donations.

    Eis-Hübinger AM, Reber U, Edelmann A, Kalus U, Hofmann J. Transfusion. 2014 Jun;54(6):1682-4. PMID: 24911910.

  • Multiple sclerosis: the elevated antibody response to Epstein-Barr virus primarily targets, but is not confined to, the glycine-alanine repeat of Epstein-Barr nuclear antigen-1.

    Ruprecht K, Wunderlich B, Gieß R, Meyer P, Loebel M, Lenz K, Hofmann J, Rosche B, Wengert O, Paul F, Reimer U, Scheibenbogen C. J Neuroimmunol. 2014 Jul 15;272(1-2):56-61. PMID: 24798244.

  • β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps.

    Raftery MJ, Lalwani P, Krautkrӓmer E, Peters T, Scharffetter-Kochanek K, Krüger R, Hofmann J, Seeger K, Krüger DH, Schönrich G. J Exp Med. 2014 Jun 30;211(7):1485-97. PMCID: 4076588.

  • A zoonotic viral threat: news about hantavirus disease.

    Krüger DH, Hofmann J, Krautkrämer E, Zeier M. Dtsch Med Wochenschr. 2014 Aug;139(31-32):1576-8. PMID: 25076309.

  • Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis.

    Kill A, Tabeling C, Undeutsch R, Kühl AA, Günther J, Radic M, Becker MO, Heidecke H, Worm M, Witzenrath M, Burmester GR, Dragun D, Riemekasten G Arthritis Res Ther. 2014 Jan 28;16(1):R29. doi: 10.1186/ar4457. PMID: 24472528

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  • Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis.

    Becker MO1, Kill A, Kutsche M, Guenther J, Rose A, Tabeling C, Witzenrath M, Kühl AA, Heidecke H, Ghofrani HA, Tiede H, Schermuly RT, Nickel N, Hoeper MM, Lukitsch I, Gollasch M, Kuebler WM, Bock S, Burmester GR, Dragun D, Riemekasten G Am J Respir Crit Care Med. 2014 Oct 1;190(7):808-17. doi: 10.1164/rccm.201403-0442OC. PMID: 25181620

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  • Rheumatoid factor or antinuclear antibodies as incidental finding.

    Biesen R1, Burmester GR, Hiepe F Internist (Berl). 2014 Oct;55(10):1157-64. doi: 10.1007/s00108-014-3588-5. PMID: 25269385

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  • High prevalence of Immunoglobulin Light Chain Gene rearrangements as revealed by FISH in Multiple Myeloma and MGUS.

    Türkmen S, Binder A, Gerlach A, Niehage S, Faber J, Melissari MT, Inandiklioglu N, Dörken B, Burmeister T Genes, Chromosomes and Cancer 2014;53:650-6. PMID: 24729354.

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  • Germline variants in IKZF1, ARID5B, and CEBPE as risk factors for adult-onset acute lymphoblastic leukemia: an analysis from the GMALL study group.

    Burmeister T, Gröger D, Bartels G, Trautmann H, Schwartz S, Lenz K, Tietze-Bürger C, Viardot A, Wäsch R, Horst HA, Reinhardt R, Gökbuget N, Hoelzer D, Kneba M, Brüggemann M haematologica 2014; 99:e23-e25. PMID:24497567.

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  • Hypomorphic, homozygous mutations in Phosphoglucomutase 3 impair immunity and increase serum IgE levels.

    Sassi A, Lazaroski S, Wu G, Haslam SM, Fliegauf M, Mellouli F, Patiroglu T, Unal E, Ozdemir MA, Jouhadi Z, Khadir K, Ben-Khemis L, Ben-Ali M, Ben-Mustapha I, Pfeifer D, Jakob T, Khemiri M, Asplund CA, Gustafsson MO, Lundin KE, Falk-Sörqvist E, Moens LN, Gungor HE, Engelhardt KR, Dziadzio M, Stauss H, Fleckenstein B, Meier R, Prayitno K, Maul-Pavicic A, Schaffer S, Rakhmanov M, Henneke P, Kraus H, Eibel H, Kölsch U, Nadifi S, Nilsson M, Bejaoui M, Schäffer AA, Edvard Smith CI, Dell A, Barbouche MR, Grimbacher B J All Clin Immunol – J Allergy Clin Immunol. 2014 May;133(5):1410-9.

  • Mutations in PGAP3 impair GPI-anchor maturation, causing a subtype of hyperphosphatasia with mental retardation.

    Howard MF, Murakami Y, Pagnamenta AT, Daumer-Haas C, Fischer B, Hecht J, Keays DA, Knight SJ, Kölsch U, Krüger U, Leiz S, Maeda Y, Mitchell D, Mundlos S, Phillips JA 3rd, Robinson PN, Kini U, Taylor JC, Horn D, Kinoshita T, Krawitz PM. Am J Hum Genet. 2014 Feb 6;94(2):278-87.

  • Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome.

    Loebel M, Strohschein K, Giannini C, Koelsch U, Bauer S, Doebis C, Thomas S, Unterwalder N, von Baehr V, Reinke P, Knops M, Hanitsch LG, Meisel C, Volk HD, Scheibenbogen C PLoS One. 2014 Jan 15;9(1):e85387. doi: 10.1371/journal.pone.0085387. eCollection 2014. PMID: 24454857

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  • Liver abscess complicated by diaphragm perforation and pleural empyema leads to the discovery of interleukin-1 receptor-associated kinase 4 deficiency.

    Schöndorf D, von Bernuth H, Simon A, Schneider G, Kölsch U, Schwarz K, Meier CM, Groe-Onnebrink J, Gortner L, Rohrer TR Pediatr Infect Dis J. 2014 Jul;33(7):767-9. doi: 10.1097/INF.0000000000000277. PMID: 24717963

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  • Effective treatment with intravenous immunoglobulins reduces autoreactive T-cell response in patients with CIDP.

    Klehmet J, Goehler J, Ulm L, Kohler S, Meisel C, Meisel A, Harms H J Neurol Neurosurg Psychiatry. 2014 Jul 29. pii: jnnp-2014-307708. doi: 10.1136/jnnp-2014-307708. Epub 2014 Jul 29 PMID: 25074566

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  • Combined immunodeficiency develops with age in Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2).

    von Bernuth H, Ravindran E, Du H, Fröhler S, Strehl K, Krämer N, Issa-Jahns L, Amulic B, Ninnemann O, Xiao MS, Eirich K, Kölsch U, Hauptmann K, John R, Schindler D, Wahn V, Chen W, Kaindl AM Orphanet J Rare Dis. 2014 Oct 21;9(1):116. doi: 10.1186/s13023-014-0116-6 PMID: 25330735

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  • Diminished HLA-DR expression on monocyte and dendritic cell subsets indicating impairment of cellular immunity in pre-term neonates: a prospective observational analysis.

    Schefold JC, Porz L, Uebe B, Poehlmann H, von Haehling S, Jung A, Unterwalder N, Meisel C J Perinat Med. 2014 Oct 25. pii: /j/jpme.ahead-of-print/jpm-2014-0226/jpm-2014-0226.xml. doi: 10.1515/jpm-2014-0226. PMID: 25418981

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  • High prevalence of immunoglobulin light chain gene aberrations as revealed by FISH in multiple myeloma and MGUS.

    Türkmen S, Binder A, Gerlach A, Niehage S, Theodora Melissari M, Inandiklioglu N, Dörken B, Burmeister T Genes Chromosomes Cancer. 2014 Aug;53(8):650-6. PMID: 24729354

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  • Copy number genome alterations are associated with treatment response and outcome in relapsed childhood ETV6/RUNX1-positive acute lymphoblastic leukemia.

    Bokemeyer A, Eckert C, Meyr F, Koerner G, von Stackelberg A, Ullmann R, Türkmen S, Henze G, Seeger K Haematologica. 2014 Apr;99(4):706-14. PMID: 24241490

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  • Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genome.

    Zemojtel T, Köhler S, Mackenroth L, Jäger M, Hecht J, Krawitz P, Graul-Neumann L, Doelken S, Ehmke N, Spielmann M, Christine Øien N, Schweiger M, Krüger U, Frommer G, Fischer B, Kornak U, Flöttmann R, Ardeshirdavani A, Moreau Y, Lewis S, Haendel S, Smedley D, Horn D, Mundlos S, Robinson P Science Translational Medicine, 2014 Sep 3;6(252):252ra123. PMID: 3009262

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  • Cupulin is a zona pellucida-like domain protein and major component of the cupula from the inner ear.

    Dernedde J, Weise C, Müller EC, Hagiwara A, Bachmann S, Suzuki M, Reutter W, Tauber R, Scherer H PLoS One 2014 Nov 4;9(11):e111917. doi: 10.1371/journal.pone.0111917. eCollection 2014.

  • Rapid Analysis of Cell Surface N-Glycosylation from Living Cells Using Mass Spectrometry.

    Hamouda H, Kaup M, Ullah M, Berger M, Sandig V, Tauber R, Blanchard V. J Proteome Res. 2014;13(12): 6144-51.

  • Improving compliance to colorectal cancer screening using blood and stool based tests in patients refusing screening colonoscopy in Germany.

    Adler A, Geiger S, Keil A, Bias H, Schatz P, deVos T, Dhein J, Zimmermann M, Tauber R, Wiedenmann B. BMC Gastroenterol. 2014 Oct 17;14:183. doi: 10.1186/1471-230X-14-183.

  • Identification of 34 N-glycan isomers in human serum by capillary elec-trophoresis coupled with laser-induced fluorescence allows improving glycan biomarker discovery.

    Schwedler C, Kaup M, Weiz S, Hoppe M, Braicu EI, Sehouli J, Hoppe B, Tauber R, Berger M, Blanchard V. Anal. Bioanal. Chem. 2014 Nov;406(28):7185-93. doi: 10.1007/s00216-014-8168-y. Epub 2014 Sep 19.

  • The Serum Glycome to Discriminate between Early-Stage Epithelial Ovarian Cancer and Benign Ovarian Diseases

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  • The fraction of varicella zos-ter virus-specific antibodies among all intrathecally-produced antibodies discriminates between patients with Varicella zoster virus reactivation and multiple sclerosis.

    Otto C., Hofmann J., Finke C., Zimmermann M., Ruprecht K. Fluid and Barriers of the CNS 11: 1-3 (2014)

  • Sialic acid methylation refines capillary electrophoresis laser-induced fluorescence analyses of immunoglobulin G N-glycans of ovarian cancer patients.

    Schwedler C, Kaup M, Petzold D, Hoppe B, Braicu EI, Sehouli J, Ehlers M, Berger M, Tauber R, Blanchard V. Electrophoresis. 2014 Apr;35(7):1025-31.

  • European Academy of Allergy and Clinical Immunology Section on Pediatrics.

    Eigenmann PA, Atanaskovic-Markovic M, O’B Hourihane J, Lack G, Lau S, Matricardi PM, Muraro A, Namazova Baranova L, Nieto A, Papadopoulos NG, Réthy LA, Roberts G, Rudzeviciene O, Wahn U, Wickman M, Høst A; European Academy of Allergy and Clinical Immunology-Clemens von Pirquet Foundation: Testing children for allergies: why, how, who and when: an updated statement of the European Academy of Allergy and Clinical Immunology (EAACI) Section on Pediatrics and the EAACI-Clemens von Pirquet Foundation. Pediatr Allergy Immunol. 2013 Mar;24(2):195-209. doi: 10.1111/pai.12066. Review. PMID: 23506293

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  • DUAL study group: Transient impact of omalizumab in pollen allergic patients undergoing specific immunotherapy.

    Kopp MV, Hamelmann E, Bendiks M, Zielen S, Kamin W, Bergmann KC, Klein C, Wahn U Pediatr Allergy Immunol. 2013 Aug;24(5):427-33. doi: 10.1111/pai.12098. Epub 2013 Jun 25. PMID:23799935

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  • The value of specific IgE to peanut and its component Ara h 2 in the diagnosis of peanut allergy.

    Lopes de Oliveira LC, Aderhold M, Brill M, Schulz G, Rolinck-Werninghaus C, Clare Mills EN, Niggemann B, Naspitz CK, Wahn U, Beyer K. J Allergy Clin Immunol Pract. 2013 Jul-Aug;1(4):394-8. doi:10.1016/j.jaip.2013.05.010. Epub 2013 Jun 28. PMID: 24565545

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  • Vitamin D in early life: good or bad for food allergies?

    Querfeld U, Keil T, Beyer K, Stock P, Pilz S, März W, Weisse K, Lehmann I Allergy. 2013 Aug;68(8):1081-3. doi: 10.1111/all.12178. No abstract available. PMID:23968384

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  • Molecular profile clustering of IgE responses and potential implications for specific immunotherapy.

    Matricardi PM Curr Opin Allergy Clin Immunol. 2013 Aug;13(4):438-45. doi: 10.1097/ACI.0b013e3283630ca5. PMID: 23799338

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  • Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA(2)LEN study.

    Tomassen P, Jarvis D, Newson R, Van Ree R, Forsberg B, Howarth P, Janson C, Kowalski ML, Krämer U, Matricardi PM, Middelveld RJ, Todo-Bom A, Toskala E, Thilsing T, Brożek G, Van Drunen C, Burney P, Bachert C Allergy. 2013 Oct;68(10):1289-97. doi: 10.1111/all.12230. Epub 2013 Oct 5. PMID: 24117882

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  • Italian Pediatric Allergy Network (I-PAN): Pollen-induced allergic rhinitis in 1360 Italian children: Comorbidities and determinants of severity.

    Dondi A, Tripodi S, Panetta V, Asero R, Businco AD, Bianchi A, Carlucci A, Ricci G, Bellini F, Maiello N, Miraglia Del Giudice M, Frediani T, Sodano S, Dello Iacono I, Macrì F, Massaccesi V, Caffarelli C, Rinaldi L, Patria MF, Varin E, Peroni D, Chinellato I, Chini L, Moschese V, Lucarelli S, Bernardini R, Pingitore G, Pelosi U, Tosca M, Paravati F, La Grutta S, Meglio P, Calvani M, Plebani M, Matricardi PM Pediatr Allergy Immunol. 2013 Dec;24(8):742-51. doi: 10.1111/pai.12136. Epub 2013 Nov 17. PMID:24236692

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  • N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis.

    Prüss H, Finke C, Höltje M, Hofmann J, Klingbeil C, Probst C, Borowski K, Ahnert-Hilger G, Harms L, Schwab JM, Ploner CJ, Komorowski L, Stoecker W, Dalmau J, Wandinger KP. Ann Neurol. 2012; 72(6):902-11. PMID: 23280840

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  • Performance of the MagNA Pure 96 System for Cytomegalovirus Nucleic Acid Amplification Testing in Clinical Samples.

    Edelmann A, Eichenlaub U, Lepek S, Krüger DH, Hofmann J. J Clin Microbiol. 2013; 51(5):1600-1. PMID: 23467597

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  • Novel Polyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for the Existence of Multiple.

    Scuda N, Madinda NF, Akoua-Koffi C, Adjogoua EV, Wevers D, Hofmann J, Cameron KN, Leendert SAJ, Couacy-Hymann E, Robbins M, Boesch C, Jarvis MA, Moens U, Mugisha L, Calvignac-Spencer S, Leendertz FH, Ehlers B PLoS Path. 2013; 9(6):e 1003429. PMID: 23818846

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  • Are there Epstein-Barr virus seronegative patients with multiple sclerosis?

    Deuschle K, Hofmann J, Otto C, Bellmann-Strobl J, Scherner O, Klumbies K, Schneider E, Broddack J, Paul F, Ruprecht K. Mult Scler. 2013 Jan 10. [Epub ahead of print] PMID: 23307904

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  • Identification of a novel human polyomavirus in organs of the gastrointestinal tract.

    Korup S, Rietscher J, Calvignac-Spencer S, Trusch F, Hofmann J, Moens U, Sauer I, Voigt S, Schmuck R, Ehlers B. PLoS One. 2013; 8(3):e58021. PMID: 23516426

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  • A self-recombinant hepatitis E virus derived from a chronically infected patient efficiently replicates in cell culture.

    Johne R, Reetz J, Ulrich RG, Machnowska P, Sachsenröder J, Nickel P, Hofmann J. J viral Hepat. June 2013 accepted

  • Organversagen und Hantavirus-Infektion: Ein in Deutschland noch unterschätzter Krankheitserreger.

    Krüger DH, Ulrich RG, Hofmann J. Deutsches Ärzteblatt 2013, Juli

  • Hantaviren als zoonotische Krankheitserreger in Deutschland.

    Krüger, Detlev H.; Ulrich, Rainer G.; Hofmann, J Deutsches Ärzteblatt Int 2013

  • Neurosarcoidosis: correlation of cerebrospinal fluid findings with diffuse leptomeningeal gadolinium enhancement on MRI and clinical disease activity.

    Wengert O, Rothenfusser-Korber E, Vollrath B, Bohner G, Scheibe F, Otto C, Hofmann J, Angstwurm K, Ruprecht K. J Neurol Sci. 2013; 15;335(1-2):124-130 PMID: 24071064

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  • Combination of immunoglobulins and natural killer cells in the context of CMV and EBV infection.

    Frenzel K, Lehmann J, Krüger DH, Martin-Parras L, Uharek L, Hofmann J. Med Microbiol Immunol. 2013 Dec 15. [Epub ahead of print] PMID: 24337366

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  • ORAL Step investigators: Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial.

    Burmester GR, Blanco R, Charles-Schoeman C, Wollenhaupt J, Zerbini C, Benda B, Gruben D, Wallenstein G, Krishnaswami S, Zwillich SH, Koncz T, Soma K, Bradley J, Mebus C Lancet. 2013 Feb 9;381(9865):451-60. doi: 10.1016/S0140-6736(12)61424-X. Epub 2013 Jan 5. PMID:23294500

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  • Urinary CD4 T cells identify SLE patients with proliferative lupus nephritis and can be used to monitor treatment response.

    Enghard P, Rieder C, Kopetschke K, Klocke JR, Undeutsch R, Biesen R, Dragun D, Gollasch M, Schneider U, Aupperle K, Humrich JY, Hiepe F, Backhaus M, Radbruch AH, Burmester GR, Riemekasten G Ann Rheum Dis. 2014 Jan 1;73(1):277-83. doi: 10.1136/annrheumdis-2012-202784. Epub 2013 Mar 8. PMID:23475982

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  • Peripheral blood sCD3- CD4+ T cells: a useful diagnostic tool in angioimmunoblastic T cell lymphoma.

    Singh A, Schabath R, Ratei R, Stroux A, Klemke CD, Nebe T, Flörcken A, van Lessen A, Anagnostopoulos I, Dörken B, Ludwig WD, Pezzutto A, Westermann J. Hematol Oncol. 2013 Jun 24. PMID:23798351

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  • Even in Pneumococcal Sepsis CD62L Shedding on Granulocytes Proves to be a Reliable Functional Test for the Diagnosis of Interleukin-1 Receptor Associated Kinase 4 Deficiency.

    Andres O, Strehl K, Kölsch U, Kunzmann S, Lebrun AH, Stroh T, Schwarz K, Morbach H, von Bernuth H, Liese J Pediatr Infect Dis J. 2013 Mar 27. [Epub ahead of print] PMID:23538514

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  • Impaired thymic function and CD4+ T lymphopenia, but not mannose-binding lectin deficiency, are risk factors for Pneumocystis jirovecii pneumonia in kidney transplant recipients.

    Schürmann M, Schürmann D, Schindler R, Meisel C, Liman P, Kruse J, Enghard P, König J, Schmidt D, Reinke P, Nickel P Transpl Immunol. 2013 Jun;28(4):159-63. doi: 10.1016/j.trim.2013.05.003. Epub 2013 May 15. PMID:23684946

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  • Terminally differentiated CD8⁺ T cells negatively affect bone regeneration in humans.

    Reinke S, Geissler S, Taylor WR, Schmidt-Bleek K, Juelke K, Schwachmeyer V, Dahne M, Hartwig T, Akyüz L, Meisel C, Unterwalder N, Singh NB, Reinke P, Haas NP, Volk HD, Duda GN Sci Transl Med. 2013 May 29;5(187):187er4. PMID:23515078

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  • Konnatale Pneumonie und pustulöse Hautveränderungen bei einem männlichen Säugling.

    Leisering J, Renner E.D, von Bernuth H, Wahn V, Rossi R Monatsschrift Kinderheilkunde 8. 2013, Juni

  • Elevation of CD4+ differentiated memory T cells is associated with acute cellular and antibody-mediated rejection after liver transplantation.

    Gerlach UA, Vogt K, Schlickeiser S, Meisel C, Streitz M, Kunkel D, Appelt C, Ahrlich S, Lachmann N, Neuhaus P, Pascher A, Sawitzki B Transplantation. 2013 Aug 27;96(4):e33. PMID:23619734

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  • Messunsicherheit und Qualitätssicherung im Bereich der Immunphänotypisierung der Lymphozytensubpopulationen im peripheren Blut.

    Nebe, Carl Thomas; Dorn-Beineke, Alexandra; Braun, Patrick; Daniel, Volker; Ilieva, Zhana; Kuling, Gudrun; Meisel, Christian; Oelschlägel, Uta; Sack, Ulrich Follow LaboratoriumsMedizin, Volume 37 (5) de Gruyter – Sep 1, 2013

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  • Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study.

    Streitz M, Miloud T, Kapinsky M, Reed MR, Magari R, Geissler EK, Hutchinson JA, Vogt K, Schlickeiser S, Kverneland AH, Meisel C, Volk HD, Sawitzki B Transplant Res. 2013 Oct 25;2(1):17. [Epub ahead of print] PMID:24160259

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  • Discrimination of T-cell subsets and T-cell receptor repertoire distribution.

    Bretschneider I, Clemente MJ, Meisel C, Guerreiro M, Streitz M, Hopfenmüller W, Maciejewski JP, Wlodarski MW, Volk HD Immunol Res. 2013 Nov 23. PMID: 24272857

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  • Blood transfusion determines postoperative morbidity in pediatric cardiac surgery applying a comprehensive blood-sparing approach.

    Redlin M., Kukucka M., Boettcher W., Schoenfeld H., Huebler M., Kuppe H. & Habazettl H. J Thorac Cardiov Sur. 2013;146(3):537-42.

  • Reply to the editor.

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  • Immature platelet count: a simple parameter for distinguishing thrombocytopenia in pediatric acute lymphocytic leukemia from immune thrombocytopenia.

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  • Invasion of Trypanosoma cruzi into host cells is impaired by N-propionylmannosamine and other N-acylmannosamines.

    Lieke T, Gröbe D, Blanchard V, Grunow D, Tauber R, Zimmermann-Kordmann M, Jacobs T, Reutter W. Glycoconj J. 28, 31 – 37 (2011)

  • Automated vs. Manual cerebrospinal fluid cell counts: a work and cost analysis comparing the Sysmex XE-5000 and the Fuchs-Rosenthal manual counting chamber.

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  • Granularity Index of the SYSMEX XE-5000 hematology analyzer as a replacement for manual microscopy of toxic granulation neutrophils in patients with inflammatory diseases.

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  • Hypoxia Enhances Platelet-derived Growth Factor Signaling in the PUlmonary Vasculature by Down-Regulation of Protein Tyrosine Phosphatases.

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  • Immature platelet count: A simple parameter for distinguishing thrombocytopenia in pediatric acute lymphocytic leukemia from immune thrombocytopenia.

    Strauß G., Vollert C., von Stackelberg A., Weimann A., Gaedicke G., Schulze H. Pediatr Blood Cancer 57 (4): 641-647 (2011)

  • Prothrombin 20210G>A genotype and C-reactive protein level.

    Hoppe B., Burmester G. R., Häupl T. Blood 118: 4495-6 (2011)

  • Prothrombin 20210G>A genotype and C-reactive protein level.

    Hoppe B., Burmester GR., Häupl T. Blood 118: 4495-4496 (2011)

  • Adipose Tissue-Derived Soluble Fms-Like Tyrosine Kinase 1 is an Obesity-Relevant Endogenous Paracrine Adipokine.

    Herse F., Fain J.N., Janke J., Engeli S., Kuhn C., Frey N., Weich H.A., Bergmann A., Kappert K., Karumanchi S.A., Luft F.C., Muller D.N., Staff A.C., Dechen R. Hypertension 7: 37-42 (2011)

  • Profiling of Endo H-released serum N-glycans using CE-LIF and MALDI-TOF-MS-application to rheumatoid arthritis.

    Frisch E., Kaup M., Egerer K., Weimann A., Tauber R., Berger M., Blanchard V. Electrophoresis 32 (24): 3510-3515 (2011)

  • Disruption of Platelet-Derived Growth Factor-Dependent Phosphatidylinositol 3-Kinase and Phospholipase CУ1 Activity Abolishes Vascular Smooth Muscle Cell Proliferation and Migration and Attenuates Neointima Formation in Vivo.

    Caglayan E., Vantler M., Leppänen O., Gerhardt F., Mustafov L., ten Freyhaus H., Kappert K., Odenthal M., Zimmermann W., Tallquist M., Rosenkranz S. J of American College of Cardiology 57 (25): 2527-2538 (2011)

  • High-Dose Treatment with Telmisartan Induces Monocytic Peroxisome Proliferator-Activated Recepter-УTarget Genes in Patients with the Metabolic Syndrome.

    Bähr I., Tretter P., Krüger J., Stark R., Schimkus J., Unger T., Kappert K., Scholze J., Parhofer K., Kintscher U. Hypertension 58 (4): 725-732 (2011)

  • Humoral anti-proteasomal autoimmunity in dilated cardiomyopathy.

    Voigt A, Bartel K, Egerer K, Trimpert C, Feist E, Gericke C, Kandolf R, Klingel K, Kuckelkorn U, Stangl K, Felix SB, Baumann G, Kloetzel PM, Staudt A. Basic Res Cardiol 2010 Jan; 105(1):9-18. PMID: 19760349

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  • Automated evaluation of autoantibodies on human epithelial-2 cells as an approach to standardize cell-based immunofluorescence tests.

    Egerer K, Roggenbuck D, Hiemann R, Weyer MG, Büttner T, Radau B, Krause R, Lehmann B, Feist E, Burmester GR. Arthritis Res Ther 2010; 12(2):R40. Epub 2010 Mar 9. PMID: 20214808

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  • Lack of evidence for a pathogenic role of proteasome-directed autoimmunity in dilated cardiomyopathy.

    Voigt A, Trimpert C, Bartel K, Egerer K, Kuckelkorn U, Feist E, Gericke C, Klingel K, Kandolf R, Felix SB, Baumann G, Kloetzel PM, Stangl K, Staudt A. Basic Res Cardiol 2010 Jul; 105(4):557-67. Epub 2010 Mar 25. PMID: 20336303

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  • Effects of early rituximab retreatment in rheumatoid arthritis patients with an inadequate response after the first cycle: retrospective arthritis cohort study.

    Bastian H, Zinke S, Egerer K, Breuer S, Safari F, Burmester GR, Feist E. J Rheumatol 2010 May; 37(5):1069-71. PMID: 20439529

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  • Clinical and serological evaluation of a novel CENP-A peptide based ELISA.

    Mahler M, Maes L, Blockmans D, Westhovens R, Bossuyt X, Riemekasten G, Schneider S, Hiepe F, Swart A, Gürtler I, Egerer K, Fooke M, Fritzler MJ Arthritis Res Ther 2010; 12 (3):R99. Epub 2010 May 20. PMID: 20487535

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  • Increased levels of BLyS and sVCAM-1 in anti-neutrophil cytoplasmatic antibody (ANCA)-associated vasculitides (AAV).

    Schneeweis C, Rafalowicz M, Feist E, Buttgereit F, Rudolph PE, Burmester GR, Egerer K. Clin Exp Rheumatol. 2010 Jan-Feb; 28 (1 Suppl 57):62-6. PMID: 20412705

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  • Immediate determination of ACPA and rheumatoid factor–a novel point of care test for detection of anti-MCV antibodies and rheumatoid factor using a lateral-flow immunoassay.

    Renger F, Bang H, Feist E, Fredenhagen G, Natusch A, Backhaus M, Burmester GR, Egerer K. Arthritis Res Ther 2010; 12(3):R120. Epub 2010 Jun 22. PMID: 20569500

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  • Cerebral Aspergillus Infections and Meningitis.

    Schwartz S. In Aspergillosis: From Diagnosis to Prevention (Hrsg. Pasqualotto AC). S. 835-52. Springer 2010.

  • Cytogenetic studies in acute leukemia patients relapsing after allogeneic stem cell transplantation.

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  • BCR-ABL positive cells and chronic myeloid leukemia in immune suppressed organ transplant recipients.

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  • Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma.

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  • Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.

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  • Systematic genetic dissection of p14ARF-mediated mitochondrial cell death signaling reveals a key role for p21CDKN1 and the BH3-only protein Puma/bbc3.

    Hemmati PG, Müer A, Gillissen B, Overkamp T, Milojkovic A, Wendt J, Dörken B, Daniel PT. J Mol Med (Berl). 2010;88:609-22. PMID: 20419447

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  • Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia.

    Burmeister T, Gökbuget N, Schwartz S, Fischer L, Hubert D, Sindram A, Hoelzer D, Thiel E. Haematologica. 2010;95:241-6. PMID: 19713226

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  • Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrom.

    Krawitz PM, Schweiger MR, Rödelsperger C, Marcelis C, Kölsch U, Meisel C, Stephani F, Kinoshita T, Murakami Y, Bauer S, Isau M, Fischer A, Dahl A, Kerick M, Hecht J, Köhler S, Jäger M, Grünhagen J, de Condor BJ, Doelken S, Brunner HG, Meinecke P, Passarge E, Thompson MD, Cole DE, Horn D, Roscioli T, Mundlos S, Robinson Nat Genet. 2010 Oct; 42(10):827-9.

  • Assessment of monocytic HLA-DR expression in ICU patients: analytical issues for multicentric flow cytometry studies.

    Monneret, G., F. Venet, C. Meisel, and J.C. Schefold Crit Care, 2010. 14(4): p. 432. PMID:20670390

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  • Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.

    Picard, C., H. von Bernuth, et al. Medicine (Baltimore), 2010. 89(6): p. 403-25. PMID:21057262

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  • High-mobility group box-1 protein serum levels do not reflect monocytic function in patients with sepsis-induced immunosuppression.

    Unterwalder, N., C. Meisel, K. Savvatis, B. Hammoud, C. Fotopoulou, H.D. Volk, P. Reinke, and J.C. Schefold Mediators Inflamm, 2010. 2010: p. 745724. PMID:20652004

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  • Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma.

    Kaiser M, Lamottke B, Mieth M, Jensen MR, Quadt C, Garcia-Echeverria C, Atadja P, Heider U, von Metzler I, Türkmen S, Sezer O. Eur J Haematol, 2010 Apr;84(4):337-44. PMID 20028416

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  • Cytogenetic studies in acute leukemia patients relapsing after allogeneic stem cell transplantation.

    Schmidt-Hieber M, Blau IW, Richter G, Türkmen S, Bommer C, Thiel G, Neitzel H, Stroux A, Uharek L, Thiel E, Blau O. Cancer Genet Cytogenet, 2010 Apr 15;198(2):135-43. Erratum in: Cancer Genet Cytogenet. 2010 Jul 1;200(1):73. PMID 20362228

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  • The allergic sensitization in infants with atopic eczema from different countries.

    Benedictis de FM, Franceschini F, Hill D, Naspitz C, Simons FE, Wahn U, Warner JO, Longueville de M (2009) EPAAC Study Group. Allergy. 2009 Feb; 64(2):295-303. PMID: 19133917

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  • Longitudinal trends of total and allergen-specific IgE throughout childhood.

    Matricardi PM, Bockelbrink A, Grüber C, Keil T, Hamelmann E, Wahn U, Lau S (2009) Allergy. 2009 Jul; 64(7):1093-8. PMID: 19630859

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  • Dynamic evolution of serum immunoglobulin E to airborne allergens throughout childhood: results from the Multi-Centre Allergy Study birth cohort.

    Matricardi PM, Bockelbrink A, Keil T, Grüber C, Niggemann B, Hamelmann E, Wahn U, Lau S (2009) Clin Exp Allergy. 2009 Oct; 39(10):1551-7. PMID: 19954429

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  • Relationship between pretreatment specific IgE and the response to omalizumab therapy.

    Wahn U, Martin C, Freeman P, Blogg M, Jimenez P. (2009) Allergy. 2009 Dec; 64(12):1780-7. PMID: 19627273

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  • A novel enzyme-linked immunosorbent assay using a mixture of human native and recombinant proteinase-3 significantly improves the diagnostic potential for antineutrophil cytoplasmic antibody-associated vasculitis.

    Damoiseaux J, Dähnrich C, Rosemann A, Probst C, Komorowski L, Stegeman CA, Egerer K, Hiepe F, van Paassen P, Stöcker W, Schlumberger W, Tervaert JW. Ann Rheum Dis 2009 Feb;68(2):228-33. PMID: 18375539

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  • Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.

    Hoppe B, Häupl T, Egerer K, Gruber R, Kiesewetter H, Salama A, Burmester GR, Dörner T. Ann Rheum Dis. 2009 Jun;68(6):898-903. Epub 2008 Jul 16. PMID: 18633125

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  • Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients.

    Hanke K, Brückner CS, Dähnrich C, Huscher D, Komorowski L, Meyer W, Janssen A, Backhaus M, Becker M, Kill A, Egerer K, Burmester GR, Hiepe F, Schlumberger W, Riemekasten G. Arthritis Res Ther 2009; 11(1):R22. Epub 2009 Feb 16. PMID: 19220911

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  • Diagnostic value of anti-topoisomerase I antibodies in a large monocentric cohort.

    Hanke K, Dähnrich C, Brückner CS, Huscher D, Becker M, Jansen A, Meyer W, Egerer K, Hiepe F, Burmester GR, Schlumberger W, Riemekasten G. Arthritis Res Ther 2009; 11(1):R28. Epub 2009 Feb 21. PMID: 19232127

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  • The serological diagnosis of rheumatoid arthritis: antibodies to citrullinated antigens.

    Egerer K, Feist E, Burmester GR. Dtsch Arztebl Int 2009 Mar;106(10):159-63 PMID: 19578391

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  • Expression of proteasomal immunosubunit beta1i is dysregulated in inflammatory infiltrates of minor salivary glands in Sjogren’s syndrome.

    Morawietz L, Martinez-Gamboa L, Scheffler S, Hausdorf G, Dankof A, Kuckelkorn U, Doerner T, Egerer K, Burmester GR, Faustman DL, Feist E. J Rheumatol 2009 Dec;36(12):2694-703. Epub 2009 Oct 15. PMID: 19833746

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  • Granulocyte macrophage-colony stimulating factor plus interleukin-2 plus alpha-interferon plus 5-fluorouracil in the treatment of metastatic renal cell cancer: induction of CD80/86+ T cells indicates adverse outcome.

    Westermann J, Hecker AC, Flörcken A, Dörken B, Pezzutto A. J Immunother. 2009;32:667-75. PMID: 19483643

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  • The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group.

    Burmeister T, Meyer C, Schwartz S, Hofmann J, Molkentin M, Kowarz E, Schneider B, Raff T, Reinhardt R, Gökbuget N, Hoelzer D, Thiel E, Marschalek R. Blood. 2009;113:4011-5. PMID: 19144982

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  • Clinical manifestation of mannose-binding lectin deficiency in adults independent of concomitant immunodeficiency.

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  • Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial.

    Meisel, C., J.C. Schefold, R. Pschowski, T. Baumann, K. Hetzger, J. Gregor, S. Weber-Carstens, D. Hasper, D. Keh, H. Zuckermann, P. Reinke, and H.D. Volk Am J Respir Crit Care Med, 2009. 180(7): p. 640-8. PMID:19590022

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  • Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis.

    Poehlmann, H., J.C. Schefold, H. Zuckermann-Becker, H.D. Volk, and C. Meisel Crit Care, 2009. 13(4): p. R119. PMID:19604380

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  • Delayed onset of (severe) combined immunodeficiency (S)CID (T-B+NK+): complete IL-7 receptor deficiency in a 22 months old girl.

    Rossberg, S., K. Schwarz, C. Meisel, S. Holzhauer, J. Kuhl, W. Ebell, V. Wahn, and H. von Bernuth Klin Padiatr, 2009. 221(6): p. 339-43. PMID:19890784

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  • Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia.

    Kim TD, Türkmen S, Schwarz M, Koca G, Nogai H, Bommer C, Dörken B, Daniel P, le Coutre P. Haematologica, 2010 Apr;95(4):582-8. Epub 2009 Dec 16. PubMed PMID: 20015884

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  • Primary versus secondary immunoglobulin E sensitization to soy and wheat in the Multi-Centre Allergy Study cohort.

    Matricardi PM, Bockelbrink A, Beyer K, Keil T, Niggemann B, Grüber C, Wahn U, Lau S (2008) Clin Exp Allergy. 2008 Mar; 38(3):493-500. PMID: 18269671

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  • Use of Phadiatop Infant in diagnosis of specific sensitization in young children with wheeze or eczema.

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    Wahn U, Warner J, Simons FE, Benedictis de FM, Diepgen TL, Naspitz CK, Longueville de M, Bauchau V (2008) Pediatr Allergy Immunol. 2008 Jun; 19(4):332-6. PMID: 18422892

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  • Specific IgE serum concentration is associated with symptom severity in children with seasonal allergic rhinitis. Omalizumab Rhinitis Study Group.

    Rolinck-Werninghaus C, Keil T, Kopp M, Zielen S, Schauer U, von Berg A, Wahn U, Hamelmann E (2008) Allergy. 2008 Oct; 63(10):1339-44. PMID: 18782113

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  • Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors.

    Mietzner B, Tsuiji M, Scheid J, Velinzon K, Tiller T, Abraham K, Gonzalez JB, Pascual V, Stichweh D, Wardemann H, Nussenzweig MC. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9727-32. PMID: 18621685

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  • Autoimmune reactivity against the 20S-proteasome includes immunosubunits LMP2 (beta1i), MECL1 (beta2i) and LMP7 (beta5i).

    Scheffler S, Kuckelkorn U, Egerer K, Dörner T, Reiter K, Soza A, Burmester GR, Feist E. Rheumatology (Oxford) 2008 May; 47(5):622-6. PMID: 18375405

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  • Celiac antibodies in the diagnostic workup of white matter lesions.

    Paul F, Pfueller CF, Wuerfel JT, Egerer K, Tanczos B, Baumgart DC, Zipp F. Neurology 2008 Jul 15; 71(3):223-5. PMID: 18625970

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  • SIT and TRIM determine T-cell fate in the thymus.

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  • Pyogenic bacterial infections in humans with MyD88 deficiency.

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  • Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma.

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